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Pharmaceutical composition for treating renal failure in pets

A pharmaceutical composition and kidney failure technology, which is applied in the field of pharmaceutical compositions for pet kidney failure, can solve the problems of high fatality rate, treatment effect and cost to be improved, and achieve the effect of improving recovery rate and good treatment results

Inactive Publication Date: 2013-09-25
林 正义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] From the above description, it can be understood that the fatality rate of the currently used pet kidney failure treatment methods is still high, and the treatment effect and cost of peritoneal dialysis and / or hemodialysis still need to be improved, so new treatment methods are still needed

Method used

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  • Pharmaceutical composition for treating renal failure in pets
  • Pharmaceutical composition for treating renal failure in pets
  • Pharmaceutical composition for treating renal failure in pets

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0077] Preparation of the composition:

[0078] Prepare liquid A and liquid B containing the following components and contents:

[0079] Solution A: 15g / L glucose, 132mEq / L sodium ion, 96mEq / L chloride ion, 3.5mEq / L calcium ion, 0.5mEq / L magnesium ion, and 40mEq / L lactate ion.

[0080] Solution B: 130mEq / L sodium ion, 109mEq / L chloride ion, 28mEq / L lactate ion, 4mEq / L potassium ion, and 3.0mEq / L calcium ion.

[0081] Detection and evaluation:

[0082] The efficacy of the treatment for renal failure provided by the present invention is evaluated by detecting BUN (blood urea nitrogen) and CRE (creatinine) values ​​and observing the pet's appearance and activity. The BUN and CRE values ​​were detected using a biochemical analyzer (SPOKEN 4430 model) sold by Yusheng Co., Ltd. The BUN and CRE values ​​of dogs and cats in different health states are listed in Table 1 below:

[0083] Table 1

[0084]

[0085] In addition, the pet's health status is assessed by observing the ...

Embodiment 1

[0088] Embodiment 1 (dog) pet name: kiki

[0089] Basic data: pet breed: Maltese dog; gender: female; age: 14 years old; weight 4 kg.

[0090] Health status of animals before administration (Day 0): Acute renal failure caused by inappropriate medication, and the health deteriorated rapidly.

[0091] Therapeutic drugs and methods: A liquid and B liquid are given by subcutaneous injection at the same time, and then (on the third day) are directly administered with A+B mixed solution, and the more doses, the less.

[0092] The therapeutic results after taking the pharmaceutical composition provided by the present invention are shown in the following table 2 and Figure 1a and Figure 1b :

[0093] Table 2

[0094] number of days day 0 day 6 Day 184 Appearance changes Lethargy and vomiting Normal and strong Normal and strong BUN (mg / dL) 92 117 17 CRE (mg / dL) 7.9 8.4 1.1

Embodiment 2

[0095] [0095] Embodiment 2 (dog) pet name: Pipi

[0096] Basic data: pet breed: mixed breed dog; sex: female; age: 6 years old; weight 18 kg.

[0097] Health status of animals before dosing (Day 0): Treatment with steroids resulted in acute renal failure and health deterioration.

[0098] Therapeutic drugs and methods: directly administered with A+B mixture.

[0099] The therapeutic results after taking the pharmaceutical composition provided by the present invention are shown in the following table 3 and Figure 2a and Figure 2b :

[0100] table 3

[0101] number of days day 0 day 13 Appearance changes bad breath vomiting Normal and strong BUN (mg / dL) 158 18 CRE (mg / dL) 6.7 1.9

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Abstract

The invention relates to a pharmaceutical composition for treating renal failure caused by various diseases in pets or pets which cannot recuperate health by a traditional renal failure medical therapy or a renal replacement renal failure medical therapy. The pharmaceutical composition comprises an A solution and a B solution, the relative proportion of the A solution and the B solution is 1: 1, the A solution and the B solution respectively contain the following ingredients and contents: the A solution comprises: 7-42.5 g / L of glucose, 70-132 mEq / L of sodium ions, 45-96 mEq / L of chloride ions, 1.5-3.5 mEq / L of calcium ions, 0.2-0.5 mEq / L of magnesium ions, and 20-40 mEq / L of lactic acid ions; the B solution comprises: 60-130 mEq / L of the sodium ions, 50-109 mEq / L of the chloride ions, 15-28 mEq / L of the lactic acid ions, 2.2-4 mEq / L of potassium ions, and 1.5-3.0 mEq / L of the calcium ions. The pharmaceutical composition provided by the invention is administrated to the pets by a subcutaneous injection for therapy, is simple in use, enables no operation, no hospitalization and / or no intravenous drips to be required, helps to quickly recuperate health, reduces medical treatment costs, substantially increases recuperation rate and reduces fatality rate. The pharmaceutical composition provided by the invention can also be applied to continuous care therapy of the renal failure in the pets.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pet kidney failure caused by various diseases. Background technique [0002] Kidney failure is one of the most common diseases in both humans and animals. When renal failure occurs, it means that more than 75% of the nephrons lose their normal physiological functions, which in turn leads to the accumulation of metabolic waste, fluid, electrolyte and acid-base imbalance, and serious systemic complications and death. Although the kidney injury caused by acute renal failure is reversible, according to the master's thesis of Chung Hsing University (Lin Kaiwei, "Assessment of Prognostic Indicators Affecting Acute Kidney Failure in Small Animals and Infection Associated with Central Venous Catheters in Dogs", Chung Hsing University Master's Research Thesis of Institute of Veterinary Medicine, 2007), acute renal failure (ARF) still has a fatality rate of 30-83% under different treatment metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61P13/12
Inventor 林正义
Owner 林 正义
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