Potassium dehydroandrographolide succinate injection and preparation method
A technology for Chuanhuning and water for injection, which is applied in the field of medicine, can solve the problems of easy hydrolysis of aqueous solutions, decreased content, and deepening of product color and luster.
Active Publication Date: 2013-10-02
CHENGDU TIANTAISHAN PHARMA
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Abstract
The invention relates to potassium dehydroandrographolide succinate injection and a preparation method, in particular to a pharmaceutical composition which comprises potassium dehydroandrographolide succinate, alkali metal salt and water for injection. The preparation method of the pharmaceutical composition comprises steps as follows: auxiliary materials such as the alkali metal salt and the like are dissolved in an appropriate amount of the water for injection, the potassium dehydroandrographolide succinate is added to the solution and stirred to be dissolved, about 0.1%-0.5% of activated carbon is added to the solution and stirred for absorption for 30 minutes, and filtration is performed to remove carbon; the water for injection is refilled to a full dose, a pH value of the solution is checked, and if necessary, an acidifying or alkalizing agent is used for adjusting the pH value of the solution to be in the range from 6.5 to 8.0; 0.4 mu m and 0.22 mu m millipore filtering films are used for filtering a liquid medicine, the liquid medicine is split and filled in glass bottles, then sealed and autoclaved at the temperature of 115 DEG C for 30 minutes, and the potassium dehydroandrographolide succinate injection is obtained. The prepared potassium dehydroandrographolide succinate injection has a good pharmaceutical property.
Application Domain
Organic active ingredientsPharmaceutical delivery mechanism +3
Technology Topic
Activated carbonChemistry +7
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