Wettable fenbendazole ivermectin powder

A technology of fenbendazole ivermectin powder and fenbendazole, which is applied in the field of wettable fenbendazole ivermectin powder and its preparation, can solve problems such as inconvenient use, and achieve improved dispersibility and preparation The effect of simple process and low production cost

Inactive Publication Date: 2013-10-09
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the disadvantages of inconvenient use of the existing compound products of abamectins and fenbendazole, and pr

Method used

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  • Wettable fenbendazole ivermectin powder
  • Wettable fenbendazole ivermectin powder
  • Wettable fenbendazole ivermectin powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 wettable fenbendazole ivermectin powder

[0026] Take 4g of fenbendazole, 0.4g of ivermectin, 2g of magnesium stearate, 61g of powdered sugar, 7g of sodium lauryl sulfate, 4g of xanthan gum, 0.8g of fresh milk essence, 0.8g of sodium saccharin, citric acid 20g of sodium, after mixing the above raw and auxiliary materials evenly, pulverize to 200 mesh ultrafine powder, pack, and obtain wettable fenbendazole ivermectin powder of the present invention.

Embodiment 2

[0027] The preparation of embodiment 2 wettable fenbendazole ivermectin powder

[0028] Take 5g of fenbendazole, 0.2g of ivermectin, 2.5g of magnesium stearate, 54.5g of powdered sugar, 9g of sodium lauryl sulfate, 2g of xanthan gum, 0.9g of fresh milk essence, 0.9g of sodium saccharin, Sodium citrate 25g, after the above-mentioned raw and auxiliary materials are mixed uniformly, pulverize to 200 mesh ultrafine powder, pack, obtain the wettable fenbendazole ivermectin powder of the present invention.

Embodiment 3

[0029] Embodiment 3 The compatibility screening of raw and auxiliary materials of wettable fenbendazole ivermectin powder

[0030] (1) Preparation of different formula products

[0031] Get the raw and auxiliary materials in the formula in Table 1, prepare wettable fenbendazole ivermectin powder according to the method of Example 1, and evaluate the pros and cons of each formula.

[0032] Table 1 The preferred scheme of wettable fenbendazole ivermectin powder formulation

[0033]

[0034]

[0035] (2) Quality evaluation of wettable fenbendazole ivermectin powder

[0036] Dispersion evaluation: Take 1 g of each wettable fenbendazole ivermectin powder prepared according to formula 1 to formula 6 in Table 1, put it into 1000 ml of drinking water, observe or stir and observe its dispersion. If the dispersion is slow and uneven, it is rated as "poor"; if the dispersion is slow, there are agglomerates or particles during the dispersion process, and it can be dispersed evenly...

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Abstract

The invention provides wettable fenbendazole ivermectin powder which is prepared from the following raw materials and auxiliary materials in parts by weight: 2.5-10 parts of fenbendazole, 0.1-0.8 part of ivermectin, 0.5-3 parts of magnesium stearate, 43.9-74 parts of powdered sugar, 3-11 parts of sodium dodecyl sulfate, 0-8 parts of xanthan gum, 0.6-1 part of fresh milk essence, 0.6-1 part of saccharin sodium and 10-30 parts of sodium citrate. The invention also provides a preparation method and application of the wettable fenbendazole ivermectin powder. The wettable fenbendazole ivermectin powder significantly improves the dispersity of the ivermectin and fenbendazole in water to ensure that the ivermectin and the fenbendazole can be uniformly distributed in the water for a long time to facilitate clinical water drinking and administration; and wettable fenbendazole ivermectin powder has a food calling function, namely that the fenbendazole ivermectin powder has a food calling function when used on faunas with sensitive tastes, such as pigs and the like. The wettable fenbendazole ivermectin powder is simple in preparation process, low in production cost and suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a wettable fenbendazole ivermectin powder and a preparation method and application thereof. Background technique [0002] Since the 1940s, the research and development of anthelmintics has been extremely hot, during which gratifying results have been achieved; especially the discovery of Avermectins in 1976 opened a new era of anthelmintic research . The compound has a very strong repelling effect on nematodes and arthropods parasitic on animals, so that the dosage of anti-helminth drugs can be reduced from mg / kg level to μg / kg level. Currently commercialized drugs in this category include Avermectin (AVM), Ivermectin (IVM), Doramectin (DRM), and Eprinomectin (Eprinomectin, EPM, also known as iplemectin, apremectin), selamectin (Selamectin, SLM) and moxidectin (Moxidectin or Milbemycin, MXD, also known as moxidectin, moxidectin) and so on. Due to its excellent anthelmintic activity and high safety, abamectins are regarded as...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/14A61P33/00A61P33/10A61P33/14A61K31/4184
Inventor 丁晓刚侯亚莉房春林李犹平
Owner CHENGDU QIANKUN VETERINARY PHARMA
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