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Blood stasis removing particles and preparation method thereof

A technology of removing blood stasis and granules in the blood house is applied in the field of traditional Chinese medicine preparation, which can solve the problems of unreachable and affecting the effectiveness of drugs, and achieve the effect of overcoming the transformation of decoction into medicine.

Inactive Publication Date: 2013-10-23
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the ancient prescription, the daily dose of crude drug of Xuefu Zhuyu Decoction should reach 76g to achieve a better effect. The comparison of the daily doses of active ingredients such as pigment A, paeoniflorin, naringin and ferulic acid shows that the content of daily intake index ingredients in conventional decoctions is much higher than that of capsules, oral liquids and other preparations that have been marketed (see the table below 1, 2), it can be seen that in terms of the index components and the daily dose of crude drug, the content of the components retained in the existing preparations cannot reach the content of the original decoction, which greatly affects the effectiveness of the drug

Method used

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  • Blood stasis removing particles and preparation method thereof
  • Blood stasis removing particles and preparation method thereof
  • Blood stasis removing particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example prepares a Xuefu Zhuyu granule, the composition and weight ratio of the raw materials of the Xuefu Zhuyu granule are: 12 parts of peach kernel; 9 parts of safflower; 9 parts of angelica; 9 parts of rehmannia; 5 parts of Chuanxiong; 6 parts of red peony; 9 parts of Achyranthes bidentata; 5 parts of bellflower; 3 parts of Bupleurum; 6 parts of Citrus aurantium;

[0035] (1) Take the above-mentioned crude drug in proportion, add 4 times the amount of water to decoct for 0.5 hour, take the filtrate, add 2 times the amount of water to decoct for 0.5 hour to filter, and combine the obtained filtrate twice;

[0036] (2) depressurizing the filtrate obtained in step (1) at -0.05Mpa and 50°C, and concentrating until the weight is twice the total weight of the crude drug to obtain an extract;

[0037] (3) Add auxiliary materials to the extract obtained in step (2), said auxiliary materials are soluble starch, add auxiliary materials whose addition amount is 0.10 times...

Embodiment 2

[0041] This example prepares a Xuefu Zhuyu granule, the composition and weight ratio of the raw materials of the Xuefu Zhuyu granule are: 12 parts of peach kernel; 9 parts of safflower; 9 parts of angelica; 9 parts of rehmannia; 5 parts of Chuanxiong; 6 parts of red peony; 9 parts of Achyranthes bidentata; 5 parts of bellflower; 3 parts of Bupleurum; 6 parts of Citrus aurantium;

[0042] (1) Take the above-mentioned crude drug in proportion, add 12 times the amount of water to decoct for 2 hours, take the filtrate, add 10 times the amount of water to decoct for 2 hours and filter, and merge the obtained filtrate twice;

[0043] (2) depressurize the filtrate obtained in step (1) under the condition of -0.05Mpa and 100°C, and concentrate until the weight is 4 times of the total weight of the raw material drug to obtain a concentrated solution;

[0044] (3) Add auxiliary materials to the concentrated solution obtained in step (2), said auxiliary materials are soluble starch, add ...

Embodiment 3

[0048] This example prepares a Xuefu Zhuyu granule, the composition and weight ratio of the raw materials of the Xuefu Zhuyu granule are: 12 parts of peach kernel; 9 parts of safflower; 9 parts of angelica; 9 parts of rehmannia; 5 parts of Chuanxiong; 6 parts of red peony; 9 parts of Achyranthes bidentata; 5 parts of bellflower; 3 parts of Bupleurum; 6 parts of Citrus aurantium;

[0049] (1) Take the above-mentioned crude drug in proportion, add 10 times the amount of water to decoct for 1 hour, take the filtrate, add 8 times the amount of water to decoct for 1 hour to filter, and merge the obtained filtrate twice;

[0050] (2) depressurizing the filtrate obtained in step (1) at -0.05Mpa and 70°C, and concentrating until the weight is 3 times the total weight of the crude drug to obtain a concentrated solution;

[0051](3) add adjuvant to the concentrated solution obtained in step (2), the adjuvant is beta-cyclodextrin, add an adjuvant whose amount is 0.3 times of the total we...

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Abstract

The invention discloses blood stasis removing particles and a preparation method thereof. The preparation method comprises the following steps of: taking 11 medicinal materials such as peach kernel, flowers carthami and Angelica sinensis in proportion according to a formula; adding 4-12 times of water to decoct for 0.5-2 hours; taking a filtrate; then, adding 2-10 times of water into the raw materials to decoct for 0.5-2 hours to filter; combining the filtrates twice; concentrating to 2-4 times of total weight of the raw material medicines; adding appropriate accessories; uniformly mixing; spraying and drying to obtain sprayed powder; and drying, pressing and prilling to obtain the particles. The particles disclosed by the invention have the advantages that the daily delivery dosage of the blood stasis removing particles can reach 76g which is consistent with that of a conventional decoction, wherein the retention rates of the effective components hydroxyl carthamin yellow A, paeoniflorin, naringin and ferulic acid are approximate to those of the decoction, so that the defect of marketed similar preparations, namely decoction patent medicines, is overcome.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparation, in particular to a Xuefu Zhuyu granule and a preparation method thereof. Background technique [0002] Xuefu Zhuyu Decoction originated from "Yilin Gaicuo" written by Wang Qingren in Qing Dynasty. Knee 9g, Bupleurum 3g, Licorice 3g. This prescription has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain. Clinically, it is mainly used for the treatment of blood stasis syndrome in the chest, chest pain, prolonged headache, pain like a pinprick in a fixed place, or persistent hiccups, internal heat and depression, palpitations, insomnia, irritability, hot flashes, and dark lips. Or the eyes are dark, the tongue is dark red or has ecchymosis, and the pulse is astringent or stringy. Xuefu Zhuyu Decoction, as a classic prescription for treating blood stasis syndrome in the chest, is widely used clinically. [0003] Under the ex...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/16A61P29/00A61P25/00A61P25/20A61P9/00
Inventor 王凤云李润美曾丽云詹丽玲张戴英童国勇刘国雄张军赖小平
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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