Memantine hydrochloride slow-release pellet preparation and preparation method thereof
A technology of memantine hydrochloride and sustained-release pellets, which is applied in the direction of bulk delivery, active ingredients of amines, nervous system diseases, etc., can solve the problems of sudden release risks and safety hazards of sustained-release tablets, and achieve long-lasting and stable drug effects. Increased safety and good fluidity
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[0020] Example 1: Preparation of memantine hydrochloride sustained-release pellets
[0021] Prescription: Raw and auxiliary materials Weight (g)
[0022] Blank pill core 799
[0023] Memantine hydrochloride 56
[0024] Hypromellose 110
[0025] Talc 25
[0026] Polyethylene glycol 10
[0027] 95% ethanol is appropriate.
[0028] Preparation method: 1) Dissolve hypromellose with 95% ethanol, and dissolve memantine hydrochloride and polyethylene glycol with 95% ethanol and add them;
[0029] 2) The blank pellet core is placed in a coating machine, and after preheating, the drug sustained-release composite layer solution obtained in step 1) is sprayed on the blank pellet core, and the air inlet temperature is controlled at 40°C to prepare drug-containing pellets;
[0030] 3) Place the drug-containing pellets obtained in step 2) in a hot-air circulating oven at 60°C to 70°C for 2 hours to obtain sustained-release pellets; to obtain sustained-release pellets.
[0031] The sustained-release pellets...
Example Embodiment
[0032] Example 2:
[0033] prescription
[0034] Raw and auxiliary materials weight (g)
[0035] Blank pill core 789
[0036] Memantine hydrochloride 56
[0037] Stearic acid 120
[0038] Povidone 10
[0039] Talc 25
[0040] 95% ethanol is appropriate.
[0041] Preparation Process:
[0042] (1) Dissolve the stearic acid, memantine hydrochloride and povidone in the prescription with 95% ethanol and fully dissolve them, and stir well;
[0043] (2) The blank pellet core is placed in a coating machine, and after preheating, the drug sustained-release composite layer solution obtained in step (1) is sprayed on the blank pellet core, and the inlet air temperature is controlled at 40°C to prepare drug-containing pellets;
[0044] (3) Dry the drug-containing pellets obtained in step (2) in a hot air circulating oven at 60°C to 70°C for 2 hours to obtain sustained-release pellets;
[0045] The sustained-release pellets are filled into hollow capsules to obtain memantine hydrochloride sustained-release ...
Example Embodiment
[0046] Example three
[0047] prescription
[0048] Raw and auxiliary materials weight (g)
[0049] Blank pill core 799
[0050] Memantine hydrochloride 56
[0051] Acrylic resin (Utech NE30D) 110
[0052] Triethyl citrate 5
[0053] 95% ethanol
[0054] Preparation Process:
[0055] (1) Dissolve the stearic acid, memantine hydrochloride and povidone in the prescription with 95% ethanol and dissolve them thoroughly, and stir them evenly.
[0056] (2) Place the blank pellet core in the storage tank of the fluidized boiling coater, and pass hot air from the bottom to make it in a fluidized state. After the drug sustained-release composite solution of step (1) is sprayed through the bottom Spray in, spray the solution on the blank core and dry.
[0057] (3) The working parameters of the fluidized boiling coater are: the air supply temperature is set to 35~60℃; the fan frequency is set to 40~50hZ; the nozzle atomization pressure is 1.5~3.0bar.
[0058] The sustained-release pellets are filled int...
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