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Applications of traditional Chinese medicine composition in preparation of drug used for inhibiting angiogenesis

A technology of angiogenesis and composition, which is applied in the direction of drug combination, cardiovascular system diseases, plant/algae/fungus/moss components, etc., can solve problems such as lack of structural integrity, cancer cell metastasis, high pressure between tissues, etc., and achieve prevention Increase and shedding of arterial plaque, inhibition of FAK phosphorylation, and inhibition of angiogenesis

Active Publication Date: 2013-12-04
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Compared with normal blood vessels, the structure of tumor blood vessels lacks integrity, there are large gaps between endothelial cells, strong permeability, disordered vascular network structure, a large number of vascular blind ends and arteriovenous short circuits, abnormalities of this structure Lead to increased exudation and high pressure between tissues, and also prone to cancer cell metastasis

Method used

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  • Applications of traditional Chinese medicine composition in preparation of drug used for inhibiting angiogenesis
  • Applications of traditional Chinese medicine composition in preparation of drug used for inhibiting angiogenesis
  • Applications of traditional Chinese medicine composition in preparation of drug used for inhibiting angiogenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The raw material formula is :

[0061] Astragalus 250g, Ligustrum lucidum 200g, Ginseng 65g, Ganoderma lucidum 65g, Curcuma 132g, Stir-fried Atractylodes macrocephala 64g, Banzhilian 128g, Gynostemma pentaphyllum 256g, Poria cocos 65g, Gallus chinensis 30g, Snakeberry 128g, Baiying 128g, Yinchen 128g, Xu Changqing 128g, ground beetle 20g, Hedyotis diffusa 128g.

[0062] The preparation method is :

[0063] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0064] (2) For ginseng and Ligustrum lucidum, add 8 times the amount of 70% ethanol for reflux extraction twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, recover the ethanol until there is no alcohol smell, and the filtrate and ginseng, female Sadako residue for use;

[0065] (3) Combine and extract the volatile oil from Curcuma, Stir-fried Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes...

Embodiment 2

[0071] The raw material formula is :

[0072] Astragalus 360g, Ligustrum lucidum 100g, Ginseng 95g, Ganoderma lucidum 30g, Curcuma 195g, Stir-fried Atractylodes macrocephala 30g, Scutellaria barbata 195g, Jiaogulan 120g, Poria cocos 95g, Gallus gallis 15g, Snakeberry 195g, Baiying 65g, Yinchen 195g, Xu Changqing 65g, ground beetle 30g, Hedyotis diffusa 65g.

[0073] The preparation method is :

[0074](1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0075] (2), ginseng, Ligustrum lucidum, add 6 times the amount of 90% ethanol to reflux and extract for 4 hours, recover the ethanol from the extract until there is no alcohol smell, and the filtrate and ginseng, Ligustrum lucidum residues are for subsequent use;

[0076] (3) Combine Curcuma, Stir-fried Atractylodes Rhizoma Atractylodes Rhizome and Xu Changqing, add 4 times the amount of water to extract the volatile oil, the oil extraction time is 10 hours, collec...

Embodiment 3

[0082] The raw material formula is :

[0083] Astragalus 120g, Ligustrum lucidum 300g, Ginseng 30g, Ganoderma lucidum 95g, Curcuma 65g, Atractylodes macrocephala 90g, Scutellaria barbata 65g, Jiaogulan 360g, Poria cocos 30g, Gallus gallus 45g, Snakeberry 65g, Baiying 195g, Yinchen 65g, Xu Changqing 195g , Wood Beetle 10g, Hedyotis diffusa 195g.

[0084] The preparation method is :

[0085] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0086] (2) For ginseng and Ligustrum lucidum, add 10 times the amount of 50% ethanol to reflux and extract twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, recover the ethanol until there is no alcohol smell, and the filtrate and ginseng, female Residues of chastity seeds for use;

[0087] (3) Merge Curcuma, Atractylodes Rhizoma Atractylodes Rhizome, and Xu Changqing, add 10 times the amount of water to extract the volatile oil, the oi...

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Abstract

The invention discloses applications of a traditional Chinese medicine composition in preparation of a drug used for inhibiting angiogenesis. The traditional Chinese medicine composition comprises traditional Chinese medicine ingredients such as radix astragali and ligustrum lucidum. The traditional Chinese medicine composition is capable of benefiting qi and nourishing yin, invigorating spleen and tonifying kidney, and removing stasis and relaxing vein; and the applications of the traditional Chinese medicine composition are right focused on pathomechanism. It is confirmed by experiments that the traditional Chinese medicine composition is capable of inhibiting angiogenesis effectively, and can be used for treating malignant tumor, rheumatoid arthritis, diabetic retinopathy and unstable arterial plaque in clinic. The traditional Chinese medicine composition is reasonable in compatibility of medicines, small in adverse drug reaction and taken by patients for a long term.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition in the preparation of drugs for inhibiting angiogenesis, which belongs to the field of traditional Chinese medicine applications. Background technique [0002] Angiogenesis (i.e., new blood vessel formation) includes angiogenesis and angiogenesis; angiogenesis refers to the formation of new blood vessels by sprouting from existing blood vessels, and angiogenesis refers to the recruitment of angioblasts / endothelial progenitor cells to the site of new blood vessel formation and differentiate into endothelial cells. Under normal circumstances, the process of angiogenesis reaches a balanced state under the precise regulation of various factors that promote angiogenesis and inhibit angiogenesis. Angiogenesis plays an important role in normal physiological processes such as human development...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10A61P35/04A61P35/00A61P19/02
Inventor 魏聪王宏涛张会欣常丽萍肖维刚安军永
Owner SHIJIAZHUANG YILING PHARMA
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