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Preparation method of nano rear earth doped gadolinium oxide bi-modal contrast medium

A dual-modality contrast agent, nano-rare earth technology, applied in rare earth metal compounds, chemical instruments and methods, nuclear magnetic resonance/magnetic resonance imaging contrast agents, etc., can solve problems such as insufficient sensitivity, and achieve the effect of low cost and simple operation

Active Publication Date: 2015-04-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Now many studies focus on studying gadolinium oxide nanomaterials as MRI contrast agents. Although MRI has high spatial resolution and good imaging depth, it also has the problem of insufficient sensitivity.

Method used

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  • Preparation method of nano rear earth doped gadolinium oxide bi-modal contrast medium
  • Preparation method of nano rear earth doped gadolinium oxide bi-modal contrast medium
  • Preparation method of nano rear earth doped gadolinium oxide bi-modal contrast medium

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Embodiment 1

[0032] Such as figure 1 As shown, the preparation method of the nano-rare earth-doped gadolinium oxide dual-mode contrast agent described in this embodiment uses laser 1 (Nd:YAG pulsed laser, laser wavelength 532nm, pulse width 10ns, energy 100mJ), total reflection mirror 2, focusing lens 3, gadolinium oxide target 4 (Gd 2 o 3 ), reaction vessel 5, rare earth ion solution, wherein the pulsed laser frequency of the laser 1 is 1-10 Hz, and in this embodiment, 10 Hz is selected; the surface of the gadolinium oxide target 4 is polished, and its purity is 99%-99.999%, the thickness is 3-5mm, the shape is round or square, and in this embodiment, the shape of the gadolinium oxide target 4 is specifically round, its purity is 99.999%, the diameter is 10mm, and the thickness is 5mm The reaction vessel 5 can be a glass container or a plastic container, and in the present embodiment, a glass container is selected; One or more combinations of holmium, erbium, thulium, ytterbium, luteti...

Embodiment 2

[0045] The difference from Example 1 is that in this example, the gadolinium oxide target 4 (purity 99.999%, diameter 10 mm, thickness 5 mm) is placed in the reaction vessel 5, and then a terbium chloride ion solution (TbCl 3 ), so that the terbium chloride ion solution is immersed in the gadolinium oxide target 4, and the upper surface of the terbium chloride ion solution is higher than the upper surface of the gadolinium oxide target 4 by 8 mm; then the laser optical path is adjusted so that the pulsed laser beam emitted by the laser 1 passes through the total reflection Mirror 2 and after passing through the focusing lens 3 with a focal length of 500 mm, the focused laser is irradiated on the contact surface of the gadolinium oxide target 4 and the terbium chloride ion solution, and a plasma plume is generated on the contact surface; then the pulse laser is turned on, and the laser frequency is selected to be 10 Hz, Perform a pulsed laser ablation reaction, and after the rea...

Embodiment 3

[0047] The difference from Example 1 is that in this example, the gadolinium oxide target 4 (purity of 99.999%, diameter of 10 mm, and thickness of 5 mm) is placed in the reaction vessel 5, and a thulium chloride ion solution (TmCl 3 ), so that the thulium chloride ion solution is immersed in the gadolinium oxide target 4, and the upper surface of the thulium chloride ion solution is higher than the upper surface of the gadolinium oxide target 4 by 8 mm; then the laser optical path is adjusted so that the pulsed laser beam emitted by the laser 1 passes through the total reflection Mirror 2 and after passing through the focusing lens 3 with a focal length of 500 mm, the focused laser is irradiated on the contact surface of the gadolinium oxide target 4 and the thulium chloride ion solution, and a plasma plume is generated on the contact surface; then the pulse laser is turned on, and the laser frequency is selected to be 10 Hz, Perform a pulsed laser ablation reaction, and after...

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Abstract

The invention discloses a preparation method of a nano rear earth doped gadolinium oxide bi-modal contrast medium. According to the method, target materials and ions of a rear earth solution react under high energy of lasers by changing different rear earth ion solutions, thereby preparing nano rear earth doped gadolinium oxide bi-modal contrast medium particles and meanwhile achieving zeugmatography and fluorescence imaging. According to the preparation method, nano materials are doped by changing different reaction liquids through an ablation method by utilizing lasers in a liquid phase environment. According to the method, the operation is simple, the cost is low, moreover severe operation environment requirements do not exist, products can be prepared under a normal-temperature normal-pressure condition, and the prepared nano particles show favorable zeugmatography and fluorescence imaging.

Description

technical field [0001] The invention relates to the medical field of a dual-mode contrast agent, in particular to a preparation method of a nanometer rare earth-doped gadolinium oxide dual-mode contrast agent. Background technique [0002] As is known in the industry, magnetic resonance imaging is one of the most commonly used diagnostic methods in medicine today. Due to its high resolution, good tissue contrast, and ability to accurately provide various anatomical details, it is now receiving more and more attention. The use of contrast agent can enhance the imaging effect by changing the relaxation image of water protons. The water forms of normal organs and diseased organs in the human body are very different. Diagnosis of diseased tissue. Gadolinium ion is considered to be the best positive contrast agent material because of its seven unpaired electrons in the outer layer. Many studies are now focusing on the study of gadolinium oxide nanomaterials as MRI contrast agen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K49/00C01F17/00B82Y30/00
Inventor 杨国伟肖俊刘璞梁英李红波
Owner SUN YAT SEN UNIV
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