Transdermal drug delivery therapeutic apparatus and transdermal drug delivery therapeutic method

Abstract

The invention discloses a transdermal drug delivery therapeutic apparatus. The transdermal drug delivery therapeutic apparatus comprises a power circuit, an MCU main control module, a man-machine interaction device, an electroporation / electricion lead-in circuit, an ultrasonic lead-in circuit and two therapeutic electrodes. The ultrasonic lead-in circuit comprises an ultrasonic oscillating circuit and a modulation circuit, wherein the signal output end of the modulation circuit is connected with the modulation signal input end of the ultrasonic oscillating circuit, and the modulation circuit is used for modulating ultrasonic signals produced by the ultrasonic oscillating circuit to obtain a plurality of ultrasonic signals with different frequencies. The invention further discloses a transdermal drug delivery therapeutic method. An ultrasonic lead-in therapeutic method includes the steps that one ultrasonic transducer corresponds to the ultrasonic oscillating circuit, and the ultrasonic signals of the ultrasonic oscillating circuit are modulated to obtain the ultrasonic signals having different frequencies and are then transmitted to the ultrasonic transducer. According to the transdermal drug delivery therapeutic apparatus and the transdermal drug delivery therapeutic method, the electroporation / electricion lead-in drug delivery therapy and the ultrasonic wave lead-in drug delivery therapy can be conducted on a patient at the same time, therefore, a drug can be rapidly and efficiently led in the skin, and a better therapeutic effect is achieved.

Description

technical field [0001] The present invention relates to a transdermal drug delivery therapeutic instrument and a transdermal drug delivery treatment method, in particular to a transdermal drug delivery therapeutic instrument and a transdermal drug delivery treatment with the functions of electroporation / iontophoresis drug delivery and ultrasonic therapy. drug treatment methods. Background technique [0002] The transdermal drug delivery system refers to a treatment method in which the drug penetrates the skin and enters the circulatory system after being administered through the skin. Transdermal drug delivery has the unique advantage of surpassing general drug delivery methods. It can avoid the "first-pass effect" of the liver and the destruction of the gastrointestinal tract, and the interlayer of the skin also has a storage function. It makes the drug concentration curve gentle, avoids the "peak-valley phenomenon", provides a predictable and long action time, maintains a...

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Problems solved by technology

However, this study uses two ultrasonic transducers to work at the same time. Although it has achieved relatively good results, the structure of the two transducers used at the same time is complex, bulky, and does not have engineering practicability and cannot be used for clinical treatment.

[0019] During drug introduction, due to the complex composition of drugs, similar and diverse molecules, different molecular weights, and large structural differences, it is necessary to find out the corresponding and different combinations of treatment parameters for different drugs through experiments, including electroporation and electroporation. The combination of parameters such as waveform, frequency, duty cycle, ultrasound, etc., all of which need to be tested and determined for different drugs, so the instrument must have a built-in combination of treatment parameters corresponding to various drugs. If all drugs use only one fixed import parameters, some drugs will have very poor import effect

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