Preparation method of ethionamide tablet
A technology of ethionamide tablets and ethionamide, which is applied in the field of medicine, can solve the problems of large difference in tablet weight, poor fluidity, and difficulty in crushing and sieving, and achieve the effect of small difference in tablet weight and quality control
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Example Embodiment
[0019] Example 1
[0020] A preparation method of ethionamide tablets, including the following steps: (preparation of 1,000 ethionamide tablets)
[0021] (1) Weigh: 250g of ethionamide crude drug; 25g of microcrystalline cellulose (filler); 30g of lactose (filler); 15g of croscarmellose sodium (disintegrant); povidone (Binder) 10g; Talc (glidant) 6.25g; Magnesium stearate (lubricant) 1g;
[0022] (2) Mix ethionamide and talc powder for 2 minutes, smash through 100 mesh standard sieve, add microcrystalline cellulose, lactose, croscarmellose sodium and povidone, mix for 3 minutes, add The total prescription amount is 6% of absolute ethanol, the above materials are wet-mixed, granulated with a 14-mesh standard sieve, dried at 60°C for 20 minutes, and a 16-mesh standard sieve is sized. The dry particles are crushed and passed through an 80-mesh standard sieve. Add magnesium stearate, mix well, press tablets, and get ready.
[0023] Film weight difference: ±2%
Example Embodiment
[0024] Example 2
[0025] A preparation method of ethionamide tablets, including the following steps: (preparation of 1,000 ethionamide tablets)
[0026] (1) Weigh: 250g of ethionamide crude drug; 30g of microcrystalline cellulose (filler); 20g of lactose (filler); 20g of croscarmellose sodium (disintegrant); povidone (Binder) 10g; Talc (glidant) 6.25g; Magnesium stearate (lubricant) 1g;
[0027] (2) Mix ethionamide and talc powder for 2 minutes, smash through 100 mesh standard sieve, add microcrystalline cellulose, lactose, croscarmellose sodium and povidone, mix for 3 minutes, add The total prescription amount is 6% of absolute ethanol, the above materials are wet-mixed, granulated with a 14-mesh standard sieve, dried at 60°C for 20 minutes, and a 16-mesh standard sieve is sized. The dry particles are crushed and passed through an 80-mesh standard sieve. Add magnesium stearate, mix well, press tablets, and get ready.
[0028] Film weight difference: ±4%
Example Embodiment
[0029] Example 3
[0030] A preparation method of ethionamide tablets, including the following steps: (preparation of 1,000 ethionamide tablets)
[0031] (1) Weigh: 250g ethionamide crude drug; 15g pregelatinized starch (filler); 25g lactose (filler); 25g croscarmellose sodium (disintegrant); povidone (Binder) 15g; Talc (glidant) 6.25g; Magnesium stearate (lubricant) 1g;
[0032] (2) Mix ethionicotinamide and talc powder for 2 minutes, smash through a 100-mesh standard sieve, add pregelatinized starch, lactose, croscarmellose sodium and povidone, mix for 3 minutes, add The total prescription amount is 6% of absolute ethanol, the above materials are wet-mixed, granulated with a 14-mesh standard sieve, dried at 60°C for 20 minutes, and a 16-mesh standard sieve is sized. The dry particles are crushed and passed through an 80-mesh standard sieve. Add magnesium stearate, mix well, press tablets, and get ready.
[0033] Film weight difference: ±3.5%
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap