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Calcium carbonate D3 granula and preparation method thereof

A technology of calcium carbonate and granules, applied in the direction of active ingredients of aluminum/calcium/magnesium, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., which can solve problems such as uneven mixing and poor stability , to solve the stability problem, the preparation process is simple, and the stability is good

Active Publication Date: 2013-12-25
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the disadvantages of poor stability and uneven mixing of existing calcium carbonate D3 granules, the object of the present invention is to provide a calcium carbonate D3 granule with uniform mixing and stable quality

Method used

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  • Calcium carbonate D3 granula and preparation method thereof
  • Calcium carbonate D3 granula and preparation method thereof
  • Calcium carbonate D3 granula and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A kind of calcium carbonate D3 granule, contains following composition by weight:

[0020] Calcium carbonate: 75 parts

[0021] Vitamin D 3 Inclusion particles: 0.15 parts

[0022] Maltodextrin: 15 parts

[0023] Glucose: 8.85 parts

[0024] Sodium citrate: 1 part

[0025] Preparation:

[0026] (1) Put calcium carbonate, maltodextrin, glucose, and sodium citrate in a wet granulator, stir and mix evenly, add purified water to granulate, dry at 60°C, and sieve through a 40-mesh sieve;

[0027] (2) Vitamin D 3 Preparation of inclusion granules: Take β-cyclodextrin and add 20 to 25 times (weight) of purified water, heat in a water bath to 40° C., and stir to dissolve it. VD 3 After dissolving in 20 to 25 times of absolute ethanol, slowly drop into the aqueous solution of β-cyclodextrin, and keep stirring, and continue to stir for 5 hours after the drop is finished. Move to the refrigerator and keep cooling at 2-8°C for 12 hours, filter with suction, wash the crysta...

Embodiment 2

[0030] A kind of calcium carbonate D3 granule, contains following composition by weight:

[0031] Calcium carbonate: 75 parts

[0032] Vitamin D 3 Inclusion particles: 0.15 parts

[0033] Maltodextrin: 15 parts

[0034] Starch: 8.85 parts

[0035] Sodium citrate: 1 part

[0036] Preparation:

[0037] (1) Put calcium carbonate, maltodextrin, starch, and sodium citrate in a wet granulator, stir and mix evenly, add purified water to granulate, dry at 60°C, and sieve through a 40-mesh sieve for granulation.

[0038] (2) Vitamin D 3 Preparation of inclusion granules: Take β-cyclodextrin and add 20 to 25 times of purified water, heat it in a water bath to 40°C, and stir to dissolve it. VD 3 After dissolving in 20 to 25 times of absolute ethanol, slowly drop into the aqueous solution of β-cyclodextrin, and keep stirring. After dropping, continue to stir for 4 hours. After cooling in the refrigerator for 18 hours, carry out suction filtration, wash the crystals twice with abs...

Embodiment 3

[0041] A kind of calcium carbonate D3 granule, contains following composition by weight:

[0042] Calcium carbonate: 75 parts

[0043] Vitamin D 3 Inclusion particles: 0.15 parts

[0044] Maltodextrin: 10 parts

[0045] Glucose: 8.85 parts

[0046] Povidone K30: 5 servings

[0047] Sodium citrate: 1 part

[0048] Preparation:

[0049] (1) Put calcium carbonate, maltodextrin, glucose, povidone K30, and sodium citrate in a wet granulator, stir and mix evenly, add purified water to granulate, dry at 60°C, and granulate with a 40-mesh sieve ;

[0050] (2) Vitamin D 3 Preparation of inclusion granules: Take β-cyclodextrin and add 20 to 25 times of purified water, heat it in a water bath to 40°C, and stir to dissolve it. VD 3After dissolving in 20 to 25 times of absolute ethanol, slowly drop into the aqueous solution of β-cyclodextrin, stirring continuously, and continue stirring for 5 hours after the drop is completed. After cooling in the refrigerator for 12 hours, perf...

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Abstract

The invention discloses a calcium carbonate D3 granula and a preparation method thereof. The calcium carbonate D3 granula is prepared by mixing calcium carbonate granules and beta-cyclodextrin inclusion powder of vitamin D3, wherein the grain size distribution of the calcium carbonate granules is consistent with that of beta-cyclodextrin inclusion powder granules of vitamin D3; the weight ratio of beta-cyclodextrin inclusion powder of vitamin D3 to the calcium carbonate granules is 4 / 10,000 to 5.7 / 1,000. By adopting the preparation method, the problems due to the stability of vitamin D3 and non-uniform mixing can be solved; the preparation process is simple; the calcium carbonate D3 granula is easily stored and has a long shelf life; the dosage is easily mastered; the calcium carbonate D3 granula is suitable for companies of various scales to produce and has a huge business prospect.

Description

technical field [0001] The invention relates to a calcium carbonate D3 granule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] In 1978, the National Ministry of Health announced a shocking figure: 37% of children and 59% of middle-aged and elderly people in my country are calcium deficient. Calcium deficiency in children can lead to short stature, calcium deficiency in pregnant women can easily cause congenital rickets in babies, calcium deficiency in the elderly can lead to loss of appetite, peptic ulcer and other problems, so the market prospect of calcium supplementation is promising. There are many calcium supplement products on the market, and calcium carbonate D3 is one of them. Calcium carbonate D3 is composed of calcium carbonate and vitamin D3 (VD 3 ) to form a compound, the advantages of which are: 1. Calcium carbonate has the highest calcium content and the best absorption rate among all current calci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K47/48A61K31/593A61K9/16A61P3/14A61P3/02
Inventor 王超志涂涛
Owner GUIZHOU LIANSHENG PHARMA
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