Extract for treating enteritis and dysentery, preparation comprising same, and preparation method and applications of preparation

An extract and dysentery technology, applied in the field of extraction for treating enteritis and dysentery, can solve the problems of large dosage, low content, single extraction process and the like, and achieve the effects of simple preparation method, high content and sufficient extraction

Active Publication Date: 2013-12-25
ANHUI JINGFANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the existing literature, the quality standard of Bailian Zhili Capsules (WS-10463(DZ-0463)-2002) discloses that the preparation method is to grind woody, berberine hydrochloride into fine powder and directly use it as medicine, and the water extracts of pomegranate peel and Pulsatilla vulgaris As medicine, the extraction process of this method is single, the active ingredients cannot be fully extracted and utilized, the content is low, there are many impurities, the dosage is large, and the curative effect is affected, which limits its application in the market. Therefore, the research and development of curative effect Rapid, high content of active ingredients, small doses of traditional Chinese medicine preparations have attracted more and more attention, and have broad market prospects

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  • Extract for treating enteritis and dysentery, preparation comprising same, and preparation method and applications of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: the preparation of capsule

[0048] Composition: 820g of pomegranate peel, 240g of pulsatilla, 12g of woody fragrance, 11g of berberine hydrochloride.

[0049] Preparation:

[0050] 1) Pomegranate peel is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 6 times the amount of 90% ethanol for 1 hour, heated and refluxed 3 times, and the extraction time is 3 hours each time. The amount of ethanol used for the second and subsequent times is the weight of the medicinal material 8 times, filter, combine the filtrates, concentrate the filtrates to a relative density of 1.10-1.30 under the condition of 65-70°C, and dry them in vacuum to obtain the extract for subsequent use;

[0051] 2) Pulsatilla slices, add 7 times the amount of 80% ethanol, heat and reflux 3 times, each extraction time is 2 hours, filter, combine the filtrate, concentrate the filtrate to 1 / 25 times the volume of the filtrate, add 4 times the amount of acetone, and precipi...

Embodiment 2

[0055] Embodiment 2: the preparation of tablet

[0056] Composition: Pomegranate peel 620g, Pulsatilla 178g, woody fragrance 13g, berberine hydrochloride 13g

[0057] Preparation:

[0058] 1) Pomegranate peel is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 8 times the amount of 70% ethanol for 2 hours, heated and refluxed 3 times, and the extraction time is 3 hours each time. The amount of ethanol used for the second and subsequent times is the weight of the medicinal material 7 times, filter, combine the filtrate, concentrate the filtrate to a relative density of 1.15-1.25 under the condition of 60-70°C, and vacuum-dry to obtain the extract for later use;

[0059] 2) Pulsatilla slices, add 7 times the amount of 785% ethanol, heat and reflux 3 times, each extraction time is 3 hours, filter, combine the filtrate, concentrate the filtrate to 1 / 30 times the volume of the filtrate, add 4 times the amount of acetone, and precipitate white Powdery, the e...

Embodiment 3

[0063] Embodiment 3: the preparation of granule

[0064] Composition: pomegranate peel 1680g, Pulsatilla 267g, woody 8g, berberine hydrochloride 8g

[0065] Preparation:

[0066] 1) Pomegranate peel is crushed into coarse powder, passed through a 24-mesh sieve, soaked in 10 times the amount of 90% ethanol for 2 hours, heated and refluxed 3 times, and the extraction time is 5 hours each time. The amount of ethanol used for the second and subsequent times is the weight of the medicinal material 10 times, filter, combine the filtrate, concentrate the filtrate to a relative density of 1.10-1.30 under the condition of 60-70°C, and vacuum-dry to obtain the extract for later use;

[0067] 2) Pulsatilla slices, add 10 times the amount of 70% ethanol, heat and reflux 4 times, each extraction time is 2 hours, filter, combine the filtrate, concentrate the filtrate to 1 / 30 times the volume of the filtrate, add 4 times the amount of acetone, and precipitate white Powdery, the ethanol e...

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Abstract

The invention relates to an extract for treating enteritis and dysentery, a preparation comprising the same, and a preparation method and applications of the preparation. The extract comprises the following traditional Chinese medicines in parts by weight: 620-1680 parts of pericarpium granati, 178-267 parts of radix pulsatillae, 8-13 parts of radix aucklandiae, and 8-13 parts of berberine hydrochloride. The preparation comprises active ingredients: an alcohol extract of pericarpium granati, a mixture of alcohol and water extracts of radix pulsatillae, an alcohol extract of radix aucklandiae and berberine hydrochloride. The extract is high in active ingredient content, the preparation method is simple, and the preparation has unexpected curative effect on the aspect of treating enteritis and dysentery.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to an extract for treating enteritis and dysentery [0002] Substances, formulations containing them, methods of preparation and applications thereof. Background technique [0003] The incidence of enteritis and dysentery in my country is high, and it can occur in all seasons, mostly in summer and autumn. The annual incidence is about 3 to 5 billion in the world, especially in developing countries, especially children. According to the World Health Organization Organization statistics show that in developing countries, infectious diarrhea is the most common infectious disease among children, with a fatality rate of about 20%. [0004] The main factors causing enteritis and dysentery include inattentive diet, low immunity, abuse of antibiotics, and genetics. At present, there are many products for the treatment of enteritis and dysentery on the market...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/185A61K36/285A61P1/12A61P31/04A61K31/4375
CPCY02A50/30
Inventor 高武李志高周宁曾香兰林必芬蒋琳琳
Owner ANHUI JINGFANG PHARMA
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