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Preparation method of curie point controllable water-soluble nano ferrite

A nano-ferrite, water-soluble technology, applied in the intersection of materials science and biomedicine, can solve problems such as limited application fields, and achieve the effects of controllable Curie temperature, fine particles, and good water solubility.

Inactive Publication Date: 2013-12-25
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent CN102731079A was finally prepared into a bulk material, mainly using its soft magnetism to prepare inductors, transformers, filter cores, magnetic heads and other devices, with limited application fields

Method used

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  • Preparation method of curie point controllable water-soluble nano ferrite
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  • Preparation method of curie point controllable water-soluble nano ferrite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) With 0.1295mol / L MnCl 2 4H 2 O solution, 0.01438mol / L ZnCl 2 Solution, 0.2877mol / LFeCl 3 ·6H 2 O solution, 1.1510mol / L NaOH solution as raw material, first take 150ml of sodium hydroxide solution and add it to a three-necked flask, put the three-necked flask in a 90°C water bath, and then add the MnCl prepared in proportion 2 4H 2 O, ZnCl 2 , FeCl 3 ·6H 2 Add 150ml of O mixed solution into the separatory funnel, add drop by drop under continuous stirring, and keep the temperature for 2h after the dropwise addition is completed after 1h.

[0030] (2) Seal the reacted precipitate with plastic wrap and age it at room temperature for 5 hours; filter and wash the aged precipitate until the solution is neutral, then put it in a vacuum drying oven and dry it under vacuum at 80°C After 24 hours, the obtained ferrite powder was ground and sieved for later use.

[0031] (3) Take 1g of the ferrite obtained above, add it to 750ml of 20% ethanol solution, and disperse i...

Embodiment 2

[0037] (1) With 0.09981mol / L MnCl 2 4H 2 O solution, 0.04277mol / L ZnCl 2 Solution, 0.2852mol / LFeCl 3 ·6H 2 O solution, 1.1407mol / L NaOH solution as raw material, first take 150ml of sodium hydroxide solution and add it to a three-necked flask, put the three-necked flask in a 90°C water bath, and then add the MnCl prepared in proportion 2 4H 2 O, ZnCl 2 , FeCl 3 ·6H 2 Add 150ml of O mixed solution into the separatory funnel, add drop by drop under continuous stirring, and keep the temperature for 2h after the dropwise addition is completed after 1h.

[0038] (2) Seal the precipitate after reaction with plastic wrap, and age at room temperature for 5 hours. The aged precipitate was filtered and washed until the solution was neutral, then put into a vacuum drying oven, dried in vacuum at 80° C. for 24 hours, and the obtained ferrite powder was ground and sieved for later use.

[0039] (3) Take 1g of the ferrite obtained above, add it to 750ml of 20% ethanol solution, and...

Embodiment 3

[0045] (1) With 0.07066mol / LMnCl 2 4H 2 O solution, 0.07066mol / LZnCl 2 Solution, 0.2822mol / LFeCl 3 ·6H 2 O solution, 1.1306mol / L NaOH solution as raw material, first take 150ml of sodium hydroxide solution and add it to the three-necked flask, put the three-necked flask in a 90°C water bath, and then add the MnCl prepared in proportion 2 4H 2 O, ZnCl 2 , FeCl 3 ·6H 2 Add 150ml of O mixed solution into the separatory funnel, add drop by drop under continuous stirring, and keep the temperature for 2h after the dropwise addition is completed after 1h.

[0046] (2) Seal the reacted precipitate with plastic wrap and age it at room temperature for 5 hours; filter and wash the aged precipitate until the solution is neutral, then put it in a vacuum drying oven and dry it under vacuum at 80°C After 24 hours, the obtained ferrite powder was ground and sieved for later use.

[0047] (3) Take 1g of the ferrite obtained above, add it to 750ml of 20% ethanol solution, and disperse ...

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Abstract

The invention relates to a preparation method of a curie point controllable water-soluble nano ferrite, which comprises the steps of allowing an MnCl2.4H2O solution, a ZnCl2 solution, an FeCl3.6H2O solution and a sodium hydroxide solution to perform precipitation reaction, ultrasonically dispersing a precipitate in an alcohol solution, allowing the precipitate to react with ethyl orthosilicate, and then with 3-amino propyltriethoxysilane after reaction, obtaining a precipitate, dispersing in a PBS (Phosphate Buffer Solution) and obtaining a final product. With the adoption of the technology, the superparamagnetic ferrite which is fine in particle, has controllable curie temperature and good water solubility, can be dissolved in PBS and is bonded with an amino group is prepared, and a foundation can be laid for the ferrite to be inoculated with a tumor antibody and a cell marker to have a target positioning effect.

Description

technical field [0001] The invention relates to a preparation method of ferrite, in particular to a preparation method of nano-ferrite with good water solubility and controllable Curie temperature, which can be used for tumor magnetic fluid hyperthermia, and belongs to the field of material science and biomedicine cross field. Background technique [0002] The new type of magnetic fluid hyperthermia (magnetic fluid hyperthermia, MFH) is a new method of deep tumor tissue hyperthermia, through nano-scale magnetic fluid hyperthermia can achieve a uniform temperature field, and cancer cells absorb surface-modified nanoparticles It is 10 times higher than that of normal cells, so "intracellular hyperthermia" enables cancer targeted therapy from the tissue or organ level to the cellular level. [0003] Magnetic fluid hyperthermia is a technology based on the physical principle of induction heat generation by magnetic media under an alternating magnetic field (AMF), using the phys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/26B82Y30/00C04B35/626
Inventor 李爱民孙康宁
Owner SHANDONG UNIV
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