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A sigmoid-targeted hollow capsule

A technology of hollow capsules and sigmoid colon, applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve problems such as inability to deliver drugs directly

Active Publication Date: 2015-12-30
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a hollow capsule that can disintegrate in the sigmoid colon, aiming at the defect that the existing colon-soluble hollow capsules cannot directly deliver the drug to the lesion site of the sigmoid colon. The technical problem to be solved is to select a suitable coating material, The coating material does not disintegrate in the colonic fluid of pH 7.8 but can disintegrate in the sigmoid fluid of pH 8.0

Method used

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  • A sigmoid-targeted hollow capsule

Examples

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Embodiment Construction

[0014] Non-limiting examples are described below:

[0015] 1. Preparation of capsule material

[0016] Put the gelatin or vegetable glue and water into the mixing kettle, heat and stir to dissolve, filter and adjust the specific gravity (that is, the concentration of the glue). Hyperdispersion. In addition, the sunscreen agent titanium dioxide and other auxiliary materials can be added according to the needs of users, and they can be kept for heat preservation to remove air bubbles, and then put into the capsule production line.

[0017] 2. Coating

[0018] Using ethanol or / and acetone as a solvent, ethyl cellulose is prepared into a 10% coating solution, and after at least one coating on the coating line, it is dried, demolded, cut, and assembled to make a sigmoid colon target. to the hollow capsule.

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Abstract

The invention provides a colon sigmoideum targeting empty capsule. The colon sigmoideum targeting empty capsule comprises a capsule wall material made from gelatin or vegetable gelatin and a coating layer outside the capsule wall material and is characterized in that the coating layer is ethyecellulose, ferric oxide is contained in the capsule wall material, the colon sigmoideum targeting empty capsule comprises the following components in percentage by weight: 65%-75% of gelatin or vegetable glue, 20-30% of the ethyecellulose, and 3-5% of the ferric oxide. The colon sigmoideum targeting empty capsule does not disintegrate within two hours in gastric juice with the pH value of 2, cannot dissolve or disintegrate within 3 hours in intestinal juice with the pH value of 6.8, does not disintegrate within 1 hour in intestinal juice with the pH value of 7.8, disintegrates within 30 minutes in colon sigmoideum juice with the pH value of 8.0 and can rapidly reach a colon sigmoideum part under the guidance of an external magnetic field.

Description

1. Technical field [0001] The invention relates to a hollow capsule of medicinal excipients, in particular to an enteric-coated hollow capsule, in particular to a targeted hollow capsule that dissolves (disintegrates) in a specific part of the human sigmoid colon. 2. Background technology [0002] The end of the sigmoid colon is connected to the rectum, which is the most prone to disease in the human colon. Therefore, the drug is directly delivered to the sigmoid colon for release, which can effectively improve the bioavailability of the drug and its curative effect. [0003] The hollow capsules specified in the 2010 edition of the Chinese Pharmacopoeia have three types: stomach-soluble, enteric-coated and colon-soluble. The disintegration time limit index for colon-soluble hollow capsules is: no disintegration in gastric juice (pH value 2.0) for 2 hours, and then in The human small intestine part (pH value 6.8) cannot be melted or disintegrated in 3 hours, but disintegrated...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/04
Inventor 刘国攀刘松林
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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