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Embolism material composition as well as preparation method and use thereof

A technology of embolization and raw materials, which is applied in the field of embolization materials and its preparation, can solve the problems affecting the curative effect and safety of embolization therapy, and the inability to timely and accurately judge the position of embolism agent and the end point of embolization, etc.

Active Publication Date: 2014-02-05
HYGEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this indirect judgment method cannot timely and accurately judge the position of the embolic agent and the end point of embolism, which affects the efficacy and safety of embolization therapy.

Method used

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  • Embolism material composition as well as preparation method and use thereof
  • Embolism material composition as well as preparation method and use thereof
  • Embolism material composition as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Embodiment 1: Preparation of embolic material

[0079] (1) Mix 0.45g of acrylic acid, 0.55g of 2-acrylamido-2-methylpropanesulfonic acid, 0.027g of N,N'-methylenebisacrylamide, 0.024g of potassium persulfate and 0.089g of tetramethylethylene disulfide Dissolve the amine in water, add the mixed solution into 40ml of liquid paraffin containing 0.005g of Span 80 under stirring, react at 55°C for 4h, collect the prepared blank microspheres, and the morphology of the microspheres under an optical microscope is as follows: figure 1 shown;

[0080] (2) Soak the blank microspheres in a solution containing 0.14g of ferric iron and 0.07g of ferrous iron, pass nitrogen into the solution, and soak for 60min;

[0081] (3) Add 8 mol / L sodium hydroxide solution to the system at 60-100°C under stirring conditions, adjust the pH value to 8-14, react for 60 minutes, and collect the prepared embolization microspheres. The following form is as figure 2 shown.

Embodiment 2

[0082] Embodiment 2: Preparation of embolic material

[0083] (1) Introduce nitrogen into the solution containing 0.34g ferric iron and 0.16g ferrous iron;

[0084] (2) Add 3mol / L diisopropanolamine solution to the system under stirring at 100°C, adjust the pH value to 8-14, react for 120min, and collect the obtained magnetic particles;

[0085] (3) Add magnetic particles to an aqueous solution containing 1g of acrylic acid, 0.2g of polyvinyl alcohol, 0.007g of N,N'-methylenebisacrylamide, 0.01g of potassium persulfate and 0.005g of tetramethylethylenediamine, The mixture was added to 50 ml of liquid paraffin containing 0.04 g of Span 80, reacted at 65° C. for 5 h, and the prepared embolization microspheres were collected.

Embodiment 3

[0086] Embodiment 3: Preparation of embolic material

[0087](1) Dissolve 1g of acrylic acid, 0.0002g of N,N'-methylenebisacrylamide, 0.0003g of potassium persulfate and 0.0005g of tetramethylethylenediamine in water, and add the mixture to the 0.028g In 40ml of liquid paraffin of Span 80, react at 50°C for 4h, and collect the prepared blank microspheres;

[0088] (2) Soak blank microspheres in a solution containing 9.8g of ferric iron and 4.9g of ferrous iron, pass nitrogen into the solution, and soak for 60 minutes;

[0089] (3) Add 25% w / w ammonia solution to the system under stirring conditions at 60-100°C, adjust the pH value to 8-14, react for 60 minutes, and collect the prepared embolization microspheres.

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Abstract

The invention provides an embolism material composition as well as preparation method and use thereof, and the embolism material is prepared from reactant raw materials through polymerization, wherein the reactant raw materials comprise a magnetic resonance imaging substance, and a monomer containing unsaturated double bonds and anion groups; in the polymer produced through the polymerization of the reactant raw materials, the magnetic resonance imaging substance is combined to the anion group of the produced polymer or dispersed in the polymer. According to the embolism material provided by the invention, a doctor is capable of monitoring and positioning the embolism material through the MRI in and after the embolization, thereby improving the curative effect and security of the embolization therapeutic.

Description

technical field [0001] The invention belongs to the field of interventional medicine, and relates to an embolic material, a preparation method and application thereof. Background technique [0002] Interventional therapy is one of the fastest growing disciplines in the 21st century. At present, it has kept pace with medical treatment and surgical treatment, and has become the third treatment system. [0003] Embolization therapy is an important part of interventional therapy and belongs to minimally invasive therapy. Embolization therapy is a local treatment that artificially blocks blood vessels by introducing embolic agents into the human body through precision instruments such as special guide wires and catheters under the guidance of medical imaging equipment. Embolization therapy has a good effect in the treatment of uterine fibroids, liver cancer, kidney cancer, hemangioma, vascular malformation and hemostasis, and has become an alternative therapy for some surgical ...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14A61L31/16A61K49/12C08F220/58C08F220/06C08F222/38C08F220/56C08F220/28
Inventor 范田园卢晓静崔代超
Owner HYGEA MEDICAL TECH CO LTD
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