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Preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and intermediate thereof

An amino and alkyl technology, applied in the field of drug synthesis, can solve the problems of long route, expensive raw materials, low yield and the like

Active Publication Date: 2014-02-12
CHIFENG PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The purpose of the present invention is to provide a novel preparation of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869) and the method of its intermediates, this process solves the problem of high production cost caused by expensive raw materials or long route and low yield in the prior art

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  • Preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and intermediate thereof
  • Preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and intermediate thereof
  • Preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and intermediate thereof

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preparation example Construction

[0101] In the preparation method of the present invention, each reaction is usually carried out in an inert solvent at a reaction temperature of -20°C to reflux temperature (preferably -10°C to 100°C). The reaction time is usually 0.1-24 hours, preferably 0.5-18 hours.

[0102] The preparation of formula I compound

[0103] Compounds of formula I can be prepared as follows:

[0104]

[0105] In the presence of a base, the compound of formula III reacts with the compound of formula IV to form the compound of formula V;

[0106] The compound of formula V is then reacted with a boron reagent in the presence of a base and a palladium catalyst to form a compound of formula I.

[0107] The starting compounds of formula III and formula IV can be prepared by conventional methods or can be purchased.

[0108] In the present invention, representative boron reagents include (but are not limited to): diboron dioxide, tetramethoxydiboronate, tetraethoxydiboronate, tetra-n-butoxydibor...

Embodiment 1

[0120] Example 1 Preparation of compound 1-I

[0121]

[0122] Step A:

[0123] Dissolve triphosgene (8.9g, 30.0mmol) in 100mL ethyl acetate, add triethylamine (10.1g, 99.8mmol), stir and cool down to -10~-5°C, slowly add 2,5-dichloro A solution of aniline (8.1 g, 50.0 mmol) in ethyl acetate (80 mL) was added dropwise for about 0.5-1 hour. After the dropwise addition was completed, the temperature was raised to 50° C. and the reaction was stirred for 1-2 hours. TLC detected that the reaction of the raw materials was complete, cooled to room temperature, and the reaction solution was directly put into the next reaction.

[0124] Step B:

[0125] The temperature of the reaction solution in the previous step was raised to 25-30°C, and a solution of p-bromoaniline (6.9g, 40.1mmol) and diisopropylethylamine (6.5g, 50.3mmol) in ethyl acetate (50mL) was added dropwise to the reaction solution , dropwise for about 0.5-1 hour. After the dropwise addition, continue to control th...

Embodiment 2

[0128] The preparation of embodiment 2 compound 2-I

[0129]

[0130] Step A:

[0131] Dissolve triphosgene (14.8g, 100.0mmol) in 100mL of tetrahydrofuran, add diisopropylethylamine (13.4g, 103.7mmol), stir and cool down to -10~-5°C, slowly add 1-amino-2 , a solution of 4-dimethylbenzene (12.1 g, 100.0 mmol) in tetrahydrofuran (120 mL) was added dropwise for about 0.5-1 hour. After the dropwise addition, the temperature was raised to reflux and the reaction was stirred for 1-2 hours. TLC detected that the reaction of the raw materials was complete, cooled to room temperature, and the reaction solution was directly put into the next reaction.

[0132] Step B:

[0133] The reaction solution in the previous step was heated to 25-30°C, potassium carbonate (13.8g, 100.0mmol) was added, and a solution of p-bromoaniline (17.2g, 100.0mmol) in tetrahydrofuran (50mL) was added dropwise to the reaction solution, and about 0.5-1 hour. After the dropwise addition, continue to contr...

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Abstract

The invention provides a preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and an intermediate thereof. Specifically, the invention provides a preparation method of a borate ester compound as shown in a formula I, and the preparation method comprises the following steps: enabling a compound as shown in a formula III to react with a compound as shown in a formula IV to generate a compound as shown in a formula V, and enabling the compound as shown in the formula V to react with a boron reagent to generate the compound as shown in the formula I. The method has the characteristics of convenience in reaction, easiness in obtainment of the intermediate, high yield, high product purity of above 98.5%, low cost of raw materials and the like, and is suitable for industrial application.

Description

technical field [0001] The invention belongs to the field of drug synthesis, in particular, the invention relates to a kind of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methyl The preparation method of phenyl) urea and its intermediate borate ester compound. Background technique [0002] Angiogenesis is a physiological process in which capillaries grow out of the existing vascular network, which can meet the nutrient supply during tissue generation and is essential for the maintenance or growth of tumors. Therefore, angiogenesis inhibitors are considered to be effective in cancer treatment. means. The receptor tyrosine kinase (RTK) of vascular endothelin plays an important role in the process of angiogenesis and can be used as the target of antitumor drugs. [0003] Abbott has developed a series of RTK inhibitors (WO2004113304A1), including indazole, benzisoxazole and benzisothiazole kinase inhibitors, which specifically inhibit all vascular endothelial growth f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/04C07D231/56
Inventor 安晓霞吕峰闫丽王关兴李慧超
Owner CHIFENG PHARMA CO LTD
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