Preparation method for ivermectin sustained-release gelatin microcapsule

Abstract

The invention relates to a method for preparation of a strong hydrophobic anthelmintic drug, i.e. an ivermectin sustained-release gelatin microcapsule by coacervation. The method includes: performing micronization treatment on ivermectin raw powder by processing so as to make the micropowder particle size meet the requirements of the prepared microcapsule particle size; then emulsifying the ivermectin in glycerin, dissolving sodium carboxymethyl cellulose in a gelatin solution, employing glycerin and sodium carboxymethyl cellulose to moderately adjust and strengthen the affinity and adsorption capacity of the main drug ivermectin and the cyst material gelatin; and then using sodium sulfate as a coagulant to make gelatin coagulate and deposit around capsule core particles so as to form a capsule membrane and achieve encapsulation.

Description

technical field [0001] The invention relates to a preparation method of slow-release gelatin microcapsules of an anthelmintic drug ivermectin, and belongs to the field of veterinary pharmaceutical preparations. Background technique [0002] Ivermectin (Ivermectin, IVM) is a new type of macrolide anti-parasitic antibiotic that is safe, efficient and broad-spectrum. It has the advantages of strong insecticidal effect, small side effects and low residue. Its anti-insect spectrum is wide, and it has been found so far that there are 3 classes (Nematoda, Insecta, Arachna), 12 orders, and 73 genera of insects that are sensitive to it in at least one stage of development. It is widely used at home and abroad to repel livestock and poultry. Insects, excellent biological insecticides. [0003] At present, there are many kinds of conventional veterinary anthelmintic preparations that use ivermectin as the main drug, such as: completely clear compound oil-soluble injections, tablets, ...

AI Technical Summary

Problems solved by technology

[0003] At present, there are many kinds of conventional veterinary anthelmintic preparations that use ivermectin as the main drug, such as: completely clear compound oil-soluble injections, tablets, powders, pouring agents, and suspensions. It has been widely used in production. These preparations are processed on the basis of the original drug through certain excipients, which facilitates clinical medication to varying degrees. However, the maintenance time of blood drug concentration is short each time. Multiple administrations are required to achieve the purpose of preventing superinfection and complete cure of parasites, and clinical application requires a lot of manpower, material and financial resources

Known existing multiple methods and materials can prepare ivermectin microspheres and microcapsules, prepare ivermectin long-acting preparations as sustained-release components thus, but, prepare microcapsules, microcapsules with different methods and materials There are large technological differences in balls, which lead to great differences in the particle size, drug loading, biocompatibility and drug release characteristics of the product, which restricts the dosage form selection and long-term effect of the preparation.

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