Medicinal composition, and its application in preparation of medicines for treating obesity, insulin resistance and diabetes

An insulin resistance and composition technology, which is applied to pharmaceutical compositions and their application fields in the preparation of medicines for the treatment of obesity, insulin resistance and diabetes, can solve the problems of high liver and kidney toxicity, and achieve the goal of improving blood sugar lowering and improving effectiveness. Effect

Inactive Publication Date: 2014-02-19
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, effective drugs for the treatment of insulin resistance and diabetes mainly include thiazolidinediones and metformin, etc. These drugs have relatively high liver and kidney toxicity

Method used

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  • Medicinal composition, and its application in preparation of medicines for treating obesity, insulin resistance and diabetes
  • Medicinal composition, and its application in preparation of medicines for treating obesity, insulin resistance and diabetes
  • Medicinal composition, and its application in preparation of medicines for treating obesity, insulin resistance and diabetes

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Experimental program
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Effect test

Embodiment Construction

[0025] The present invention will be further described below in conjunction with the accompanying drawings, the purpose of which is to better understand the content of the present invention, rather than limit the protection scope of the present invention.

[0026] 1. Experimental equipment

[0027] Blood glucose measuring instrument (Johnson & Johnson), precision electronic balance, 1mL syringe, animal scale, etc.

[0028] 2. Experimental animals and materials

[0029] 2.1 Experimental animals

[0030] C57 mice, clean grade, male, weighing 16±20 g, were provided by the Experimental Animal Center of Fourth Military Medical University.

[0031] SD rats, clean grade, male, weighing 180±220g, were provided by the Experimental Animal Center of Fourth Military Medical University.

[0032] 3T3-L1 preadipocyte cell line was purchased from Shanghai Fuxiang Biotechnology Co., Ltd.

[0033] 2.2 Experimental materials

[0034] Normal saline, picric acid, blood glucose test strips, in...

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Abstract

The invention discloses a medicinal composition and its application in the preparation of medicines for treating obesity, insulin resistance and diabetes. The medicinal composition containing sodium salicylate and oleanolic acid is injected to the abdominal cavity of a diabetic animal to substantially reduce the blood sugar level, and the composition containing sodium salicylate and oleanolic acid is added to a culture solution of differentiated 3T3-L1 adipocytes to substantially inhibit the tumor necrosis factor induced insulin signal disorder, so the composition containing sodium salicylate and oleanolic acid can be used in medicines for treating the obesity, the diabetes, the insulin resistance, and insulin resistance closely related metabolic syndromes.

Description

technical field [0001] The present invention relates to the use of sodium salicylate and oleanolic acid drug combination, in particular to the application of sodium salicylate and oleanolic acid drug combination in treating obesity, insulin resistance and diabetes. Background technique [0002] Currently, obesity has become a global health problem. If it continues to become serious, obesity will soon overtake smoking as the largest single risk factor for premature death in the United States, reducing the quality of life and increasing social costs. According to the US CDC statistics, 1 / 3 of American adults are already obese, and 1 / 3 of them are overweight, and the degree of obesity is increasing year by year. According to a study in the Journal of the American Medical Association, more than 160,000 people in the United States die "accidentally" each year from obesity. According to scientists, the average obese person costs society more than $7,000 a year due to increased p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61P3/04A61P5/50A61P3/10A61P1/16A61P3/06A61K31/56
Inventor 王欣海春旭
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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