Preparation method and application of traditional Chinese medicine composition and Chinese patent medicine for treating rheumatic bone disease

A rheumatic bone disease, Chinese patent medicine technology, applied in the direction of drug combination, bone disease, medical formula, etc., can solve problems such as not suitable for long-term use, poor quality controllability, large safety hazards, etc., to prevent and treat adjuvant arthritis, enhance The ability to release NO and the effect of inhibiting secondary foot swelling

Inactive Publication Date: 2016-05-11
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned existing Chinese patent medicines and invention patents contain a wide variety of medicines with complex ingredients, poor quality controllability, large safety hazards, and large dosages.
Moreover, the medicinal materials used are all powdered medicines, which contain many ineffective substances, some of which have toxic and side effects, and are not suitable for long-term use.

Method used

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  • Preparation method and application of traditional Chinese medicine composition and Chinese patent medicine for treating rheumatic bone disease
  • Preparation method and application of traditional Chinese medicine composition and Chinese patent medicine for treating rheumatic bone disease
  • Preparation method and application of traditional Chinese medicine composition and Chinese patent medicine for treating rheumatic bone disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A traditional Chinese medicine composition for treating rheumatic bone disease, the formula mass percentage of each active part is as follows:

[0052]

[0053] The method for preparing the Chinese patent medicine for the treatment of rheumatic bone disease according to the Chinese medicine composition of the present invention comprises the following steps:

[0054] (1) Preparation of Glycyrrhizin

[0055] ①Take the licorice powder and ultrasonically extract it twice with 0.5% ammoniacal 70% ethanol (the percentages of the reagents involved in the following are all mass percentages), each time for 1 hour;

[0056] ② Extract by filtration and centrifugation, rotary steam to about 300mL, add deionized water, let stand overnight, and centrifuge;

[0057] ③Through HZ-816 macroporous resin column (use 1200mL deionized water, 600mL30% ethanol, 600mL50% ethanol, 600mL70% ethanol to elute in sequence), collect 70% ethanol eluate;

[0058] ④ The alcohol solution was rotary ...

Embodiment 2

[0080] According to the Chinese medicine composition of the present invention, the method for preparing a Chinese patent medicine for the treatment of rheumatic bone disease comprises the following steps:

[0081] Preparation method and step are substantially the same as Example 1, and the difference from Example 1 is:

[0082] Glycyrrhizin saponins, licorice flavones, ephedra alkaloids, achyranthes saponins and strychnium seed alkaloids prepared in steps (1)-(5) are prepared according to the traditional Chinese medicine composition for treating rheumatic bone disease, and the quality of each active part The percentage is:

[0083]

Embodiment 3

[0085] According to the Chinese medicine composition of the present invention, the method for preparing a Chinese patent medicine for the treatment of rheumatic bone disease comprises the following steps:

[0086] Preparation method and step are substantially the same as Example 1, and the difference from Example 1 is:

[0087] Glycyrrhizin saponins, licorice flavones, ephedra alkaloids, achyranthes saponins and strychnium seed alkaloids prepared in steps (1)-(5) are prepared according to the traditional Chinese medicine composition for treating rheumatic bone disease, and the quality of each active part The percentage is:

[0088]

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatism bone disease. The traditional Chinese medicine composition comprises the active parts by the mass percentage: 40%-60% of glycyrrhizin, 10%-20% of licoflavone, 5%-20% of ephedra alkaloids, 5%-20% of radix cyathulae saponins, and 5%-10% of strychnos alkaloids. A method for preparing Chinese patent medicines according to the traditional Chinese medicine composition comprises the following steps: (1) preparing the glycyrrhizin; (2) preparing the licoflavone; (3) preparing the ephedra alkaloids; (4) preparing the radix cyathulae saponins; (5) preparing the strychnos alkaloids; (6) preparing the active part composition; and (7) producing the Chinese patent medicines for treating rheumatism bone disease. The Chinese patent medicines comprise capsules, soft capsules and tablets. The Chinese patent medicines prepared according to the traditional Chinese medicine composition and used for treating rheumatism bone disease can be applied in easing pain, resisting inflammatory, promoting blood circulation, removing blood stasis, tonifying middle-jiao, replenishing qi, enhancing immunity and treating rheumatic arthritis and arthralgia caused by cold-dampness blocking meridians and collaterals.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine, in particular to a preparation method and application of a traditional Chinese medicine composition for treating rheumatic bone disease and a Chinese patent medicine (hereinafter referred to as "Chinese patent medicine"). Background technique [0002] Rheumatic diseases, commonly known as "rheumatism", are caused by wind, cold, dampness, and trauma invading the human body, forming arthralgia poison and attaching to human bones, thereby damaging bones and hard tissues related to bones, resulting in muscle, ligament, synovial bursa, tendon A type of disease caused by poor nutrient supply of membranes. Among these diseases, 99% are rheumatic bone diseases, which is one of the most common chronic bone diseases today. As early as in ancient Chinese medicine, there were relevant descriptions of the disease. Rheumatism belongs to the category of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/56A61P29/00A61P19/02A61P37/04A61K31/352
Inventor 倪力军张立国吴婷婷赵雯雯欧阳霄雯徐晓玲郭燕子薛志斌何婉瑛潘洁文郑帅赵丽丽马东升
Owner EAST CHINA UNIV OF SCI & TECH
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