Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition

A technology for oral disintegrating tablets and compositions, which is applied in the directions of drug combinations, non-active components of polymer compounds, plant raw materials, etc., can solve the problems of practical use restrictions, inconvenience, inconvenience of water intake, difficulty in taking patients, etc., and achieve intestinal residues. The effect of less, less side effects, and easy control of the preparation method

Active Publication Date: 2014-02-19
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Yinzhihuang is suitable for children with jaundice, it is limited to its dosage form, and its actual use is subject to certain restrictions
[0003] At present, most of the common Yinzhihuang are tablets and capsul

Method used

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  • Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition
  • Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition
  • Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1: Preparation of freeze-dried orally disintegrating tablets of Yinzhihuang composition, based on 1000 pieces.

[0036] prescription:

[0037]

[0038] Dissolve the prescription amount of Yinzhihuang in 80% purified water of the total amount of prescription water, heat it to 55°C under stirring, continue to stir and add the prescription amount of chitosan nanoparticles and sucralose. Gelatin was dissolved in purified water with 20% of the prescription water, heated to complete dissolution, combined the above two solutions and stirred uniformly, adjusted the pH value to 5.5-6.5 with sodium bicarbonate, according to the Yinzhihuang composition freeze-dried orally disintegrating tablet After confirming the specifications, the combined liquid medicine is divided into medicine dishes according to the quantity, and placed in a freeze-drying box, the liquid medicine is frozen, and the Yinzhihuang composition freeze-dried orally disintegrating tablet is dried After that, it...

Example Embodiment

[0039] Example 2: Preparation of freeze-dried orally disintegrating tablets of Yinzhihuang composition, based on 1000 tablets.

[0040] prescription

[0041]

[0042] Dissolve the prescription amount of ribavirin in 80% purified water of the total amount of prescription water, heat to 55°C under stirring, continue stirring and add the prescription amount of mannitol and sucralose, and dissolve the prescription amount of gelatin in the prescription In purified water with 20% water consumption, heat until completely dissolved, combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with sodium bicarbonate, and determine the packaging according to the specifications of the Yinzhihuang composition freeze-dried orally disintegrating tablet After the amount, the combined liquid medicine is divided into medicine dishes according to the quantity, and placed in a freeze-drying box to freeze the liquid medicine. After the Yinzhihuang composition freeze-dried orally di...

Example Embodiment

[0043] Example 3: Preparation of freeze-dried orally disintegrating tablets of Yinzhihuang composition, based on 1000 tablets.

[0044] prescription

[0045]

[0046] Dissolve the prescription amount of ribavirin in 80% purified water of the total amount of prescription water, heat to 55°C under stirring, continue stirring and add the prescription amount of mannitol and sucralose, and dissolve the prescription amount of gelatin in the prescription In purified water with 20% water consumption, heat until completely dissolved, combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with sodium bicarbonate, and determine the packaging according to the specifications of Yinzhihuang composition freeze-dried orally disintegrating tablets After the amount, the combined medicinal solution is divided into the medicinal dishes according to the filled amount, and placed in a freeze-drying box, and the medicinal solution is frozen. After the Yinzhihuang composition free...

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Abstract

The invention provides a freeze-drying oral-cavity disintegrating piece of a Yinzhihuang composition and belongs to the technical field of medicine and medicine preparation. The freeze-drying oral-cavity disintegrating piece comprises the following raw materials in parts by weight: 6.0-16.32 parts of Yinzhihuang, 81.62-90.01 parts of chitosan nanoparticle, 1.96-3.84 parts of gelatin and 0.09-0.14 part of sucralose. The freeze-drying oral-cavity disintegrating piece of the Yinzhihuang composition is simple in components, people can take the freeze-drying oral-cavity disintegrating piece without water or masticating, and the disintegration time of the composition in the oral cavity does not exceed 2 seconds. The freeze-drying oral-cavity disintegrating piece has the advantages of rapid absorption, high biological availability, little intestinal canal residue, low side effect, small first-pass effect in liver and good taste and is particularly suitable for infants.

Description

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Claims

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Application Information

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Owner HAINAN WEI KANG PHARMA QIANSHAN
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