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Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition

A technology for oral disintegrating tablets and compositions, which is applied in the directions of drug combinations, non-active components of polymer compounds, plant raw materials, etc., can solve the problems of practical use restrictions, inconvenience, inconvenience of water intake, difficulty in taking patients, etc., and achieve intestinal residues. The effect of less, less side effects, and easy control of the preparation method

Active Publication Date: 2014-02-19
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Yinzhihuang is suitable for children with jaundice, it is limited to its dosage form, and its actual use is subject to certain restrictions
[0003] At present, most of the common Yinzhihuang are tablets and capsules. When people take the medicine, they usually need to take it with warm water. It will be difficult for patients who have difficulty swallowing or have trouble getting water, especially for children. It is inconvenient.

Method used

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  • Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition
  • Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition
  • Freeze-drying oral-cavity disintegrating piece of Yinzhihuang composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1. Preparation of Yinzhihuang Composition Composition Freeze-dried orally disintegrating tablets, counted in 1000 pieces.

[0036] prescription:

[0037]

[0038] Dissolve the Yinzhihuang of the prescribed amount in 80% of the purified water of the total amount of prescription water, heat to 55°C under stirring, continue to stir and add the chitosan nanoparticles and sucralose of the prescribed amount, and add the prescribed amount of Dissolve gelatin in purified water with 20% prescription water consumption, heat until completely dissolved, combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with sodium bicarbonate, freeze-dry orally disintegrating tablets according to the composition of Yinzhihuang Specifications, after determining the loading volume, divide the combined medicinal solution into medicinal dishes according to the loading volume, put it into a freeze-drying box, freeze the medicinal solution, and wait for the Yinzhi...

Embodiment 2

[0039] Example 2. Preparation of Yinzhihuang Composition Composition Freeze-dried orally disintegrating tablets, counted as 1000 tablets.

[0040] prescription

[0041]

[0042] Dissolve the prescribed amount of ribavirin in purified water of 80% of the total amount of prescription water, heat to 55°C under stirring, continue stirring and add the prescribed amount of mannitol and sucralose, and dissolve the prescribed amount of gelatin in the prescription Heat the purified water with 20% water consumption until completely dissolved, combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with sodium bicarbonate, and determine the packaging according to the specifications of the Yinzhihuang composition freeze-dried orally disintegrating tablets. After measuring, the combined medicinal solution is divided into medicinal dishes according to the loading amount, and put into a freeze-drying box to freeze the medicinal solution. After the Yinzhihuang compo...

Embodiment 3

[0043] Example 3. Yinzhihuang Composition Preparation of freeze-dried orally disintegrating tablets, counted as 1000 tablets.

[0044] prescription

[0045]

[0046] Dissolve the prescribed amount of ribavirin in purified water of 80% of the total amount of prescription water, heat to 55°C under stirring, continue stirring and add the prescribed amount of mannitol and sucralose, and dissolve the prescribed amount of gelatin in the prescription Heat the purified water with 20% water consumption until completely dissolved, combine the above two solutions and stir evenly, adjust the pH value to 5.5-6.5 with sodium bicarbonate, and determine the packaging according to the specifications of the Yinzhihuang composition freeze-dried orally disintegrating tablets. After measuring, the combined medicinal solution is divided into medicinal dishes according to the loading amount, and put into a freeze-drying box to freeze the medicinal solution. After the Yinzhihuang composition freez...

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Abstract

The invention provides a freeze-drying oral-cavity disintegrating piece of a Yinzhihuang composition and belongs to the technical field of medicine and medicine preparation. The freeze-drying oral-cavity disintegrating piece comprises the following raw materials in parts by weight: 6.0-16.32 parts of Yinzhihuang, 81.62-90.01 parts of chitosan nanoparticle, 1.96-3.84 parts of gelatin and 0.09-0.14 part of sucralose. The freeze-drying oral-cavity disintegrating piece of the Yinzhihuang composition is simple in components, people can take the freeze-drying oral-cavity disintegrating piece without water or masticating, and the disintegration time of the composition in the oral cavity does not exceed 2 seconds. The freeze-drying oral-cavity disintegrating piece has the advantages of rapid absorption, high biological availability, little intestinal canal residue, low side effect, small first-pass effect in liver and good taste and is particularly suitable for infants.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a freeze-dried orally disintegrating tablet of Yinzhihuang composition. Background technique: [0002] Yinzhihuang contains three components: baicalin, gardenia, and capillary. Scutellaria baicalensis is bitter and cold, dries dampness and expels heat; Modern studies have shown that Yinchen contains a variety of choleretic components, which can promote bile secretion and reduce the tension of Oddi's sphincter; gardenia contains hydroxygeniposide, which can significantly reduce blood bilirubin levels; . In recent years, with the rapid development of medicine and in-depth research on Yinzhihuang, its application scope is expanding day by day, and its curative effects are remarkable in clearing away heat, promoting dampness, reducing jaundice, protecting liver and reducing ALT. Yinzhihuang, as a traditional pure Chinese medicine preparation for reducing ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K47/42A61K47/36A61K47/26A61K9/20A61P1/16A61K31/7048
Inventor 汪六一汪金灿郝结兵
Owner HAINAN WEI KANG PHARMA QIANSHAN
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