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Paeonol extraction separation method

A separation method, the technology of paeonol, applied in the field of paeonol extraction and separation, can solve the problems of high energy consumption, long production cycle, high equipment cost, etc., and achieve the effects of improving economic benefits, stable components, and simple method

Inactive Publication Date: 2014-02-19
安徽德昌药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alcohol extraction and steam distillation have the defects of high energy consumption, long production cycle and low yield
CO 2 Although the supercritical fluid extraction method has high extraction efficiency, it is difficult to industrialize production due to the high cost of equipment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] Paeonol extraction and separation method, take Moutan cortex or Xu Changqing medicinal materials, crush them, put them into the extraction kettle, add alkaline water to decoct, cool and centrifuge the decoction liquid, remove the supernatant liquid, pass through ODS column or macroporous adsorption resin column after concentration, Carry out gradient elution with water again, 30% ethanol, 60% ethanol and 95% ethanol respectively, collect eluent, concentrate and dry, place to crystallize, obtain paeonol, described Moutan cortex weight (g) and alcohol volume ( ml) ratio is 1:5.

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Abstract

The invention discloses a paeonol extraction separation method which comprises the steps of grinding cortex moutan radicis or cynanchum paniculatum, putting into an extraction kettle, adding alkaline water for decocting, cooling and centrifuging decoction, removing supernate, treating with an ODS (octadecylsilyl) column or a macroporous adsorbent resin column after condensing, performing gradient elution with water, 30% alcohol, 60% alcohol and 95% alcohol respectively, collecting eluant, condensing, drying, placing for crystallization, and obtaining paeonol. The method is simple and novel, the extraction recovery rate is high, ingredients are stable, and the economic benefit is improved.

Description

technical field [0001] The invention relates to the technical field of paeonol extraction, in particular to a paeonol extraction and separation method. Background technique [0002] Paeonol is the main active ingredient in Moutan cortex. It is volatile and can be distilled out with water vapor under a certain vapor pressure. It is a colorless needle-like crystal at room temperature, and its solubility in water is very low. The current experimental research shows that the main pharmacological effects of Cortex Moutan are relatively extensive. With the rise of traditional Chinese medicine and the increasing material and cultural level of the people, the demand for health care products has greatly increased, and the country has attached great importance to traditional Chinese medicine, which has greatly promoted the development and recognition of traditional Chinese medicine technology. At present, the domestic demand for paeonol is 160-200 tons, most of which depend on import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/84C07C45/78
CPCC07C45/78
Inventor 葛德州孙伟修效友
Owner 安徽德昌药业股份有限公司