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A kind of novel anilide compound and its application

A technology of anilides, compounds, applied in the field of organic synthesis and medicine

Active Publication Date: 2016-06-01
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because HPV has strong resistance, high recurrence rate, can tolerate desiccation, and is easy to survive for a long time, the above method is only applicable to various benign lesions, and it is still helpless to eradicate HPV infection or treat cervical cancer caused by HPV

Method used

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  • A kind of novel anilide compound and its application
  • A kind of novel anilide compound and its application
  • A kind of novel anilide compound and its application

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0044] The preparation of embodiment 1 parahydroxyacetanilide ( figure 1 )

[0045]Acetic anhydride and 4-aminophenol in a molar ratio of 1:1 were refluxed in dichloromethane for 10 minutes. After the reaction, the solvent was removed under reduced pressure and recrystallized with ethanol to obtain the corresponding products with yields greater than 90%.

Embodiment 2

[0046] The preparation of embodiment 2 p-methoxyacetanilide ( figure 2 )

[0047] Take N-(4-hydroxyphenyl)acetamide and methyl iodide at a molar ratio of 1:1.1 in anhydrous potassium carbonate-dried acetone solution for reflux reaction for 3 hours. After the reaction, remove the solvent under reduced pressure and recrystallize with ethanol to obtain The corresponding product yields are all greater than 90%.

Embodiment 3

[0048] The preparation of embodiment 3 p-acetoxy acetanilide ( image 3 )

[0049] N-(4-hydroxyphenyl)acetamide and acetyl chloride in a molar ratio of 1:1 were refluxed in dichloromethane and triethylamine for 2 hours. After the reaction, the solvent was removed under reduced pressure and recrystallized from ethanol to obtain the corresponding The product yields are all greater than 80%.

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Abstract

The invention discloses a novel acyl aniline compound. The novel acyl aniline compound has the structure shown in the specification. Experiments prove that the novel acyl aniline compound can be used for preventing and treating clinical symptoms triggered by HPV (Human Papillomavirus) infection, in particular, verruca vulgaris, verruca plana, verruca plantaris, vulvar cancer, penile cancer, anal epidermoid cancer, prostatic cancer, bladder cancer, cervical cancer, rectal cancer, oral cancer, tonsil cancer, and the like. The novel acyl aniline compound provided by the invention has the advantages such as simple preparation method, low production cost and prominent HPV resisting effect, and has a significant potential application value in the aspect of developing HPV-resisting drugs.

Description

technical field [0001] The invention belongs to the field of organic synthesis and medicine, and specifically relates to a novel anilide compound and its application in anti-HPV. Background technique [0002] Human papillomavirus (HPV) belongs to the genus Papillomavirus A of the family Papillomaviridae, and is a non-enveloped double-stranded circular epitheliophilic DNA virus with a small molecular weight (7.9Kb) [1] , often cause the proliferation of squamous epithelial cells of human skin and mucous membranes. There are more than 200 genotypes of HPV found at present, which can be divided into: skin low-risk types (such as HPV1, 2, 3, 4, 7, 10, 12, 15, etc., and common Warts, flat warts, plantar warts), skin high risk (such as HPV5, 8, 14, 17, 20, 36, 38, etc., and verrucous epidermal dysplasia, vulvar cancer, penile cancer, anal cancer, prostate cancer, bladder cancer Cancer-related), mucosal low-risk types (such as HPV6, 11, 13, 32, 34, 40, 42, 43, 44, 53, 54, etc., r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C233/25C07C237/04C07C233/60C07C231/02C07C231/12C07D215/38A61P31/20A61P17/12A61P35/00
Inventor 刘天军赵力挥洪阁
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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