Preparation method and application of multiple-response nanogel
A nano-gel, multi-response technology, applied in non-active ingredients medical preparations, pharmaceutical formulations, etc., can solve the problems of limited industrial application, complex post-purification process, etc., to achieve enhanced hydrophilicity and broad application prospects. Effect
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Embodiment 1
[0040] Preparation of 2-nitrobenzyl methacrylate: Dissolve 4.21 g of 2-nitrobenzyl alcohol and 7.68 ml of triethylamine in a 100 ml round-bottomed flask filled with dichloromethane, and place the round-bottomed flask at 0°C in an ice-water mixture bath. The dichloromethane solution dissolved in methacryloyl chloride was added dropwise into the round bottom flask. The whole reaction system was protected with nitrogen, and the reaction time was 12 hours. After the reaction, the reaction mixture was poured into a separatory funnel, and washed twice with aqueous sodium hydroxide solution. The organic layer was taken out from the separatory funnel and dried over anhydrous sodium bisulfate for 12 hours. The obtained crude product was purified by silica gel column chromatography (the chromatographic solution was a mixed solution of n-hexane and ethyl acetate with a volume ratio of 6:1). The product obtained was a pale yellow liquid.
[0041] Prepare the polymer. The 5 mL am...
Embodiment 2
[0046] Preparation of 2-nitrobenzyl methacrylate: Dissolve 8.42 g of 2-nitrobenzyl alcohol and 23.04 ml of triethylamine in a 100 ml round-bottomed flask filled with dichloromethane, and place the round-bottomed flask at 0 °C in an ice-water mixture bath. The dichloromethane solution dissolved in methacryloyl chloride was added dropwise into the round bottom flask. The whole reaction system was protected with nitrogen, and the reaction time was 12 hours. After the reaction, the reaction mixture was poured into a separatory funnel, and washed twice with aqueous sodium hydroxide solution. The organic layer was taken out from the separatory funnel and dried over anhydrous sodium bisulfate for 12 hours. The obtained crude product was purified by silica gel column chromatography (the chromatographic solution was a mixed solution of n-hexane and ethyl acetate with a volume ratio of 6:1). The product obtained was a pale yellow liquid.
[0047] Prepare the polymer. The 5 mL ...
Embodiment 3
[0053] Preparation of 2-nitrobenzyl methacrylate: Dissolve 6.315 g of 2-nitrobenzyl alcohol and 5.76 ml of triethylamine in a 100 ml round-bottomed flask filled with dichloromethane, and place the round-bottomed flask at 0 °C in an ice-water mixture bath. The dichloromethane solution dissolved in methacryloyl chloride was added dropwise into the round bottom flask. The whole reaction system was protected with nitrogen, and the reaction time was 12 hours. After the reaction, the reaction mixture was poured into a separatory funnel, and washed twice with aqueous sodium hydroxide solution. The organic layer was taken out from the separatory funnel and dried over anhydrous sodium bisulfate for 12 hours. The obtained crude product was purified by silica gel column chromatography (the chromatographic solution was a mixed solution of n-hexane and ethyl acetate with a volume ratio of 6:1). The product obtained was a pale yellow liquid.
[0054] Prepare the polymer. The 5 mL ...
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