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Traditional Chinese medicine compound for resisting swine influenza virus

A swine influenza virus and compound technology, which is applied in antiviral agents, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of few experimental studies on swine influenza virus and the inability to comprehensively evaluate the anti-swine influenza virus effect of traditional Chinese medicine compounds. , to achieve the effect of prevention and treatment of swine flu

Inactive Publication Date: 2014-03-19
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Looking at the current experimental research on the anti-virus of traditional Chinese medicine compounds, there are many researches on human influenza A virus and avian influenza virus, but less experimental research on swine influenza virus
Moreover, most of them are independently studied by in vivo test or in vitro test, which cannot comprehensively evaluate the anti-swine influenza virus effect of traditional Chinese medicine compound

Method used

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  • Traditional Chinese medicine compound for resisting swine influenza virus
  • Traditional Chinese medicine compound for resisting swine influenza virus
  • Traditional Chinese medicine compound for resisting swine influenza virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Anti-swine influenza virus effect in vitro of Chinese medicine compound preparation

[0039] 1. Determination of half infectious dose (EID50) of SIV on chicken embryos

[0040] The virus liquid was sequentially diluted 10 times, and inoculated in the allantoic cavity of 10-day-old chicken embryos, each dilution was inoculated with 0.2ml / piece, and 4 replicates were made, and normal chicken embryos were set as a control at the same time. Place them in an incubator at 37°C for 72 hours, discard the dead embryos within 24 hours, harvest the allantoic fluid of the dead embryos after 24 hours and live embryos after 72 hours, and measure the titer of HA. EID50 was calculated according to the Reed-Muench method.

[0041] 2. Determination of the maximum safe concentration of traditional Chinese medicine compound preparations on chicken embryos

[0042] Dilute the traditional Chinese medicine extract by 2 times in turn, and dilute it to the original concentration, 1...

Embodiment 2

[0056] Example 2 Prevention and treatment effect of traditional Chinese medicine compound on swine influenza virus infection mice

[0057] 1. Protective effect and prolong lifespan of traditional Chinese medicine compound on swine influenza virus-infected mice

[0058] (1) Grouping of experimental animals

[0059] BALB / c mice were randomly divided into normal control group, model control group, ribavirin group and Chinese medicine compound group, totally 4 groups, 10 mice in each group.

[0060] (2) Administration of experimental animals

[0061] Mice in each group were administered intragastrically, 2 times / d, 0.2 ml / time. Each group of traditional Chinese medicine was administered 1 day before infection and continued for 5 days. At the same time, the normal control group and the model control group were given the same amount of distilled water

[0062] (3) Experimental animal challenge

[0063] After the mice were anesthetized with ether, except for the normal control ...

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Abstract

The invention discloses a traditional Chinese medicine compound for resisting a swine influenza virus. The traditional Chinese medicine compound comprises traditional Chinese medicine species and content, and is prepared from the following drugs in parts by weight: 20-30 parts of ephedra, 10-15 parts of bitter apricot kernel, 10-15 parts of fried licorice root, 15-25 parts of gypsum and 10-15 parts of fructus forsythia. In vivo and in vitro experiments show that the traditional Chinese medicine compound preparation disclosed by the invention can effectively resist the swine influenza virus.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine for veterinary use, and relates to a traditional Chinese medicine compound for inhibiting swine influenza virus in vivo and in vitro. Background technique [0002] Swine influenza (swine influenza, SI), also known as swine influenza, is an acute, febrile, highly contagious respiratory disease caused by swine influenza virus (swine influenza virus, SIV) of the family Orthomyxoviridae. Infectious diseases are clinically characterized by sudden onset, high fever, cough, dyspnea, recurrent attacks, high morbidity, and low mortality. The disease occurs all over the world, causing serious harm, huge economic losses, and a threat to human health. Its prominent epidemic feature is that it often exists in a subclinical form and often causes secondary or mixed infections of other respiratory bacteria and viruses, such as porcine reproductive and respiratory syndrome, porcine circovirus disease, ...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61P31/16A61K33/06
Inventor 王丙云陈胜锋陈志胜计慧琴徐振娜冼琼珍
Owner FOSHAN UNIVERSITY