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Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof

A technology for capsules and stasis removal, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations with non-active ingredients, etc. The effect of body characteristics and content stability

Inactive Publication Date: 2014-03-19
JILIN LONGXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Patent CN1966052A discloses a kind of Danhuang Quyu Tablet, which improves the stability of medicine by adding auxiliary materials carboxymethyl starch sodium, starch and magnesium stearate in the extract, but in practical application, there are relatively large amounts of auxiliary materials in this tablet. Large and the effect of improving stability is not obvious, etc.

Method used

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  • Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof
  • Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof
  • Blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Step 1: Dry and pulverize 75g of scorpion, 45g of curcuma, 75g of ground beetle and 75g of corydalis into fine powder, pass through a 100-mesh sieve for later use;

[0016] Step 2: 150g of astragalus, 150g of salvia miltiorrhiza, 75g of codonopsis pilosula, 75g of Chinese yam, 100g of Smilax smilax, 75g of angelica, 150g of spatholobus, 75g of Gorgon, 150g of Houttuynia cordata, 45g of trigonum, 150g of Patrinia, cinnamon 15g, 45g Atractylodes Rhizome, 22.5g Pao Jiang, 45g Toosendan and 75g Sophora flavescens, add water and decoct three times, add 10 times the amount of water to extract for 3 hours, add 8 times the amount of water to extract for 2 hours, add 8 times the amount of water to extract for 2 hours, add 8 times the amount of water to extract Extract with water for 1 hour, filter, combine the filtrates, concentrate to an extract with a relative density of 1.28-1.30 at 60°C;

[0017] Step 3: Mix the fine powder and extract evenly, dry, and crush into fine powder...

Embodiment 2-6

[0019] Except the following table parameter, other preparation processes are with embodiment 1, specifically see the following table:

[0020]

Embodiment 7

[0021] Example 7 Stability Investigation of Danhuang Quyu Capsules Prepared in Examples 1-3

[0022] According to the stability guidelines of the second appendix of the Chinese Pharmacopoeia 2010 edition, the stability of the relevant samples was investigated, and the stability of the drug was investigated at 25°C for 36 months, and at 25°C and a relative humidity of 75% for 60 days. The contents of astragaloside IV, tetrahydropalmatine and salvianolic acid B in the capsules were determined by HPLC.

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Abstract

The invention relates to a traditional Chinese medicinal preparation, and concretely relates to a blood stasis removing capsule containing Salvia miltiorrhiza and Radix Astragali, and a preparation method thereof. The capsule is composed of a traditional Chinese medicinal extract product and auxiliary materials. A weight ratio of the traditional Chinese medicinal extract product to the auxiliary materials is 10:0.2-0.8; the traditional Chinese medicinal extract product is prepared by using the following raw materials, by weight, 150 parts of Radix Astragali, 150 parts of Salvia miltiorrhiza, 75 parts of Radix Codonopsis, 75 parts of Chinese yam, 100 parts of Glabrous Greenbrier Rhizome, 75 parts of Chinese angelica, 150 parts of Millettia dielsiana, 75 parts of Semen Euryales, 150 parts of Herba Houttuyniae, 45 parts of Rhizoma Sparganii, 150 parts of Herba Patriniae, 15 parts of cinnamon, 45 parts of Rhizoma Atractylodis Macrocephalae, 22.5 parts of baked ginger, 45 parts of Fructus Toosendan, 75 parts of Sophora flavescens, 75 parts of scorpion, 45 parts of Rhizoma Curcumae, 75 parts of ground beetle and 75 parts of Corydalis tuber; and the auxiliary materials comprise, by weight, 5-10 parts of crosslinked sodium carboxymethyl cellulose, 1-3 parts of alpha-lactose and 2-6 parts of microcrystalline cellulose.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Danhuang Quyu capsule and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Danhuang Quyu Capsule is recorded in the "National Compilation of Chinese Patent Medicine Standards" (the local standard of Chinese patent medicine has risen to the National Standard Section of Surgical Gynecology). It has the effects of promoting blood circulation and relieving pain, softening hard masses and dispelling stagnation. It is used for chronic pelvic inflammatory disease caused by qi deficiency, blood stasis, stagnation of phlegm dampness, and increased leucorrhea. The original process is to dry and pulverize the scorpion, ground beetle, corydalis, and curcuma in the prescription into fine powder, add water to decoct the remaining 16 herbs three times, each time for 1-3 hours, combine the decoction, filter, and co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61K47/38A61K47/26A61P15/00
Inventor 孙灵飞徐健柳桂英李淑娟
Owner JILIN LONGXIN PHARMA
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