A kind of hydrolysis method of pleuromutilin
A technology for pleuromutilin and hydrolyzate, which is applied in chemical instruments and methods, preparation of organic compounds, preparation of carbon-based compounds, etc., can solve problems such as large environmental pollution and complicated product processing, and achieve high product yield and production efficiency. The effect of short cycle and reduced usage
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Embodiment 1
[0020] Slowly add 2 times the volume of sulfuric acid aqueous solution with a concentration of 1mol / L to the pleuromutilin butyl acetate extract with a mass volume concentration of 10%, and raise the temperature to 80°C for 6 hours under stirring; after the reaction is completed, let it stand Separate the layers, discard the water phase, concentrate the upper butyl acetate phase in vacuum at 65°C, add hot water 0.5 times the volume of the concentrated solution, and wash twice. After washing, add anhydrous sodium sulfate to dehydrate, and filter; The temperature of the solution was slowly lowered to 0°C, the product was precipitated, filtered and dried to obtain the hydrolyzed product of pleuromutilin. Yield 94%, purity 92.4%.
Embodiment 2
[0022] Slowly add 2 times its volume, 1.5 mol / L sulfuric acid aqueous solution to the 12% pleuromutilin butyl acetate extract, stir and raise the temperature to 90°C for 6 hours; layer, discard the water phase, concentrate the upper butyl acetate phase in vacuum at 70°C, add hot water 1 times the volume of the concentrated solution to wash 3 times, add anhydrous sodium sulfate to dehydrate, and filter; the filtrate Slowly lower the temperature to 0°C, the product precipitates, and is filtered and dried to obtain pleuromutilin hydrolyzate. Yield 90%, purity 93.7%.
Embodiment 3
[0024] Slowly add 3 times its volume, 2mol / L sulfuric acid aqueous solution to the pleuromutilin butyl acetate extract with a mass volume concentration of 15%, and heat up to 80°C for 5 hours under stirring; after the reaction is completed, let stand and separate , discard the water phase, vacuum concentrate the upper butyl acetate phase at 70°C, add hot water 1 times the volume of the concentrated solution to wash 3 times, add anhydrous calcium chloride for dehydration after washing, and filter; the filtrate Slowly lower the temperature to 5°C, the product precipitates, and is filtered and dried to obtain the pleuromutilin hydrolyzate. Yield 89%, purity 95.6%.
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