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Natural pharmaceutical composition, and preparation method and applications thereof

A technology of natural medicines and compositions, applied in the directions of drug combinations, pharmaceutical formulations, antitumor drugs, etc., to achieve the effects of convenience, obvious synergies, and high industrial practicability

Inactive Publication Date: 2014-03-26
张宗升
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that has the effect of alleviating diarrhea against cancer chemotherapy

Method used

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  • Natural pharmaceutical composition, and preparation method and applications thereof

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Embodiment approach

[0034] The first step: preparation of various extracts

[0035] (1) Preparation of the concentrated extract of Alisma chinensis decoction

[0036] According to the compatibility ratio of 1-4:1, take Alisma and white wood, soak in distilled water, heat and decoct, filter with silk cloth, add distilled water to the dregs, soak, decoct and filter in the same way, mix the two filtrates, heat and concentrate , filtered with an ultrafiltration membrane, and dried under reduced pressure.

[0037] (2) Preparation of alisol terpene alcohol B acetate

[0038] Percolate Alisma coarse powder with 80% ethanol, recover ethanol to 10%, put the oily extract on a silica gel column, elute with petroleum ether-ethyl acetate at a volume ratio of 10:1, and then use a solvent ratio of 10 : 3 petroleum ether-ethyl acetate elution, thin-layer chromatography detection, collect fractions, obtain crystallization, and then use petroleum ether-ethyl acetate recrystallization, promptly obtains alisol ter...

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Abstract

The invention relates to a natural pharmaceutical composition, and a preparation method and applications thereof. The natural pharmaceutical composition is composed of rhizoma alismatis and aquilaria sinensis water decocted concentrated extract, alisol B acetate, aquilaria sinensis chloroform extract, and aquilaria sinensis hexane extract at a ratio of 2-6:1-6:1-7:4-6. The natural pharmaceutical composition possesses excellent curative effect on cancer chemotherapy related diarrhea.

Description

technical field [0001] The present invention relates to a natural medicine composition, more specifically to a natural medicinal composition consisting of the concentrated extract of Alisma alisia basilica, Alisma terpene alcohol B acetate, chloroform extract of A. A pharmaceutical composition, a preparation method of the natural pharmaceutical composition and an application of the natural pharmaceutical composition in the preparation of medicines for reducing cancer chemotherapy-associated diarrhea. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs are cytotoxic anti-tumor drugs, which can cause diarrhea and other side effects when used alone or in combination. Diarrhea after tumor chemotherapy is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P1/12A61P35/00A61K36/835
Inventor 张宗升
Owner 张宗升