Bone grafting material by embedding bone material gel in PRF (platelet-rich fibrin)

A bone material and bone grafting technology, applied in medical science, prosthesis, etc., can solve the problems of fast degradation, complicated operation, and high risk of biological preparations, and achieve the effects of slow degradation, simple operation, and strong tension.

Active Publication Date: 2014-04-02
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a bone graft material embedded in bone material gel in the PRF in order to solve the defects of high risk of use of biological agents, rapid degradation, and complicated operation in the existing bone material technology.

Method used

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  • Bone grafting material by embedding bone material gel in PRF (platelet-rich fibrin)
  • Bone grafting material by embedding bone material gel in PRF (platelet-rich fibrin)
  • Bone grafting material by embedding bone material gel in PRF (platelet-rich fibrin)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Use an empty Vacuette tube to collect 4ml of non-anticoagulated whole blood. Put the blood sample into the centrifuge immediately (Anke TDL-80-2D China), adjust the centrifugal force at 130g, and centrifuge for 4 minutes; take out the layered blood sample, the upper layer is turbid light yellow liquid, the lower layer is the red blood cell layer, and the middle white film The layer is very unclear; suck all the upper layer of turbid light yellow liquid into the ceramic double dish; pipette 500μl into the other hole of the double dish, pour the prepared 50mg Bio-Oss bone meal particles with a diameter of 0.25mm, so that the yellow liquid naturally penetrates the bone meal In the granules; let stand at room temperature. After 30 minutes, use tweezers to pick up the yellow and white PRF-bone meal particles gel mass, which is the target product. The PRF-bone meal particle gel formed into a mass with tweezers has certain elasticity and toughness, and the bone meal particles ...

Embodiment 2

[0031] Use an empty Vacuette tube to collect 4ml of non-anticoagulated whole blood. Put the blood sample into the centrifuge immediately (Anke TDL-80-2D China), adjust the centrifugal force of 270g, and centrifuge for 3 minutes; take out the layered blood sample, the upper layer is turbid light yellow liquid, the lower layer is the red blood cell layer, and the middle is very Tulle membrane layer; suck all the upper layer of light yellow liquid into the ceramic double dish; add 500μl into the other hole of the double dish, pour the prepared 50mg Bio-Oss bone meal particles with a diameter of 0.25mm, so that the yellow liquid naturally penetrates the bone meal particles Medium; let stand at room temperature. After 30 minutes, use tweezers to pick up the yellow and white PRF-bone meal particles gel mass, which is the target product. The PRF-bone meal particle gel formed into a mass with tweezers has certain elasticity and toughness, and the bone meal particles are not easy to fa...

Embodiment 3

[0033] Use an empty Vacuette tube to collect 4ml of non-anticoagulated whole blood. Put the blood sample into the centrifuge immediately (Anke TDL-80-2D China), adjust the centrifugal force of 390g, and centrifuge for 2 minutes; take out the layered blood sample, the upper layer is light yellow liquid, the lower layer is the red blood cell layer, and the middle white film layer ; Inhale all the light yellow liquid above the albuginea layer into the ceramic double dish; add 500μl into the other hole of the double dish, pour the prepared 50mg Bio-Oss bone meal particles with a diameter of 0.25mm into the yellow liquid, so that the yellow liquid naturally penetrates the bone meal In the granules: stand at room temperature, 35 minutes later, use tweezers to pick up the yellow and white PRF-bone meal granules gel mass, which is the target product. The PRF-bone meal particle gel formed into a mass with tweezers has certain elasticity and toughness, and the bone meal particles are not...

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Abstract

The invention relates to a bone grafting material by embedding a bone material gel in PRF (platelet-rich fibrin), and belongs to the field of bone grafting operation. The bone grafting material is prepared by the following steps: performing centrifugal operation on a non-anticoagulant blood sample by a centrifugal machine at a centrifugal force of 130-460g; mixing all upper yellow liquid and the bone material, and standing for 30-40 minutes at room temperature to obtain the bone grafting material. The bone grafting material is a whole clot, PRF in the product reacts with the bone material, leukocyte and platelet in PRF are uniformly distributed, and PRF is widely and comprehensively contacted with the bone material. The bone grafting material is high in plasticization, and is a perfect bone grafting material with a complete frame supporting structure.

Description

Technical field [0001] The invention relates to a bone graft material embedded with bone material gel in a PRF, and belongs to the field of materials for bone graft surgery. Background technique [0002] Healing after bone grafting needs to go through 3 main stages, hematoma organizing stage (2 weeks), this stage is mainly platelet aggregation and activation, granulocytes and macrophages migration; primitive callus formation period (3-8 weeks) , Is the proliferation, differentiation, and reproduction period of mesenchymal cells; the shaping period (8-12 weeks) the reconstruction of various tissue cells. The aggregation of platelets in the organizing phase of hematoma initiates the coagulation reaction. There are two ways to complete the whole process, one is repair and the other is regeneration. The repair process is that when the tissue damage exceeds a certain limit, the proliferation and differentiation of mesenchymal cells cannot meet the requirements of tissue regeneration....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/54
Inventor 陈智滨栾庆先
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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