Lipid gel medicinal preparation, preparation method thereof and purpose thereof

Abstract

The invention relates to a lipid gel medicinal preparation, a preparation method and a purpose. The lipid gel medicinal preparation comprises PEGylated phosphatide, non-PEGylated phosphatide, an active substance with effective treatment amount and a solvent, wherein the solvent contains water or physiological aqueous medium. The preparation method comprises the following steps: i) preparing an active substance solution; ii) mixing the above active substance solution with PEGylated phosphatide, non-PEGylated phosphatide, the solvent and other pharmaceutically acceptable accessory with a prescription amount; and iii) heating and mixing a solution obtained in the step ii), and fully swelling. The invention also comprises an application of the lipid gel in a slow release drug delivery system. The preparation has high maximum drug loading, is suitable for large scale production, and has the advantages of simple preparation method, low toxicity and obvious slow release effect.

Description

Technical field [0001] The invention relates to a lipid gel pharmaceutical preparation and its preparation method and application. Background technique [0002] The vesicular phospholipid gel (VPG) is a semi-solid phospholipid dispersion. It resembles vesicles in morphology, but is different from liposome gel and ordinary liposome compartment structure in the traditional sense. Due to the formation of a unique three-dimensional network structure, VPG can be used as a drug "reservoir" to control drug release. The increased phospholipid consistency reduces the spacing between adjacent vesicles. The final result is a certain volume of water phase in and between the closed vesicles, which is suitable for loading water-soluble, fat-soluble and amphiphilic drugs. Especially for water-soluble drugs, the almost equal volume of the water phase inside and outside the vesicle not only increases the encapsulation efficiency, but also the concentration of the inside and outside drugs tends ...

AI Technical Summary

Problems solved by technology

[0010] HE Warriner et al reported in Science 16February 1996:Vol.271no.5251pp.969-973 that the gel with PEG-DMPE was added, the viscosity of the system increased with the increase of water content, but the maximum The water content is only 90%, no drug is loaded and contains amyl alcohol as a co-solvent

Images