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Process for preparing fritillaria pallidiflora total alkaloids

A technology of total alkaloids and preparation process, which is applied in the directions of medical preparations containing active ingredients, plant raw materials, plant/algae/fungus/moss components, etc., can solve problems such as environmental hazards, high production costs, and unfavorable large-scale production. , to achieve the effect of low extraction temperature, guarantee and product quality, and prevent escape

Inactive Publication Date: 2014-04-16
新疆伊禧堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction process of total alkaloids of Fritillaria mainly adopts the organic solvent extraction method, which uses a large amount of toxic, flammable and explosive organic solvents, which not only leads to high production costs, but also is harmful to humans and the environment. Conducive to large-scale industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1, the preparation process of this total alkaloids of Ignea japonicus is: take by weighing 500g of Igumboe japonicus coarse powder after drying, pulverizing, and sieving, add 4 times the amount of 4% ammonia solution for soaking for 12 hours, and obtain Wet powder, then the gained wet powder is placed in supercritical fluid extraction equipment, with CO 2 As the extraction agent, set the extraction temperature to 35°C, the extraction pressure to 25MPa, the flow rate of the entrainer to 2ml / min, and the extraction time to 1.5 hours. After the extraction is completed, the extract is obtained and placed in a vacuum drying oven at a temperature of 50°C. Dry to obtain total alkaloids. The extraction rate of the total alkaloids obtained is 0.20%, and the total alkaloids in the extract of the iberia japonicus account for 50%.

Embodiment 2

[0008] Example 2, the preparation process of the total alkaloids of Igami japonicus is as follows: take 500 g of Igami japonicus coarse powder after drying, pulverizing and sieving, add 2 times the amount of 2% sodium hydroxide solution and soak for 12 hours , to get the wet powder, then place the obtained wet powder in a supercritical fluid extraction equipment, and use CO 2 As the extraction agent, set the extraction temperature to 40°C, the extraction pressure to 20MPa, the flow rate of the entrainer to 31 / min, and the extraction time to 1 hour. After the extraction is completed, the extract is obtained and placed in a vacuum drying oven at a temperature of 60°C. Drying is carried out to obtain total alkaloids. The extraction rate of the total alkaloids obtained is 0.23%, and the total alkaloids in the extract of the iberia japonicus account for 55%.

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Abstract

The invention discloses a process for preparing fritillaria pallidiflora total alkaloids. The process comprises the following steps: baking, crushing and screening a fritillaria pallidiflora medicinal material to obtain coarse powder, adding into 2-4 times amount of 1-5 percent alkaline aqueous solution, and immersing for 12 hours to obtain wet powder; putting the wet powder in supercritical fluid extraction equipment, extracting by using CO2 as an extracting agent and the flowing speed of an entrainer of 2-3ml / min at a temperature of 30-50 DEG C and pressure of 20-40Mpa for 1-3 hours to obtain an extract; drying the extract in a vacuum drying tank to obtain the total alkaloids. The process has the advantages that 1, the extraction temperature is low, escape of thermosensitive substances can be effectively prevented, and activity of effective substances can be maintained; 2, CO2 is non-toxic, tasteless, non-combustible and non-corrosive, and cannot cause hazard to human health or pollution to environment; 3, supercritical CO2 has the effects of resisting oxidation and sterilizing, and is advantageous to guaranteeing and improving the product quality.

Description

technical field [0001] The invention relates to a method for extracting total alkaloids from Iberia japonicus, belonging to the technical field of separation and extraction of chemical components of traditional Chinese medicines. Background technique [0002] The dried bulbs of Xinjiang Fritillaria or Yili Fritillaria, which belong to the Liliaceae family, are one of the medicinal Fritillaria. It is mainly distributed in the Ili River Basin in Xinjiang, and is mainly produced in Yili, Bole and Jinghe. It is currently found in Yili, Tacheng, Changji, Shihezi, Beijing, Hebei, Shandong, Gansu, Inner Mongolia, Shaanxi, Henan and Jilin. All are introduced and cultivated. The bulb of Iberia japonicus is used as medicine. It tastes bitter and cold in nature. It has the functions of clearing away heat and nourishing the lungs, resolving phlegm, relieving cough and dispelling stagnation. Due to the high yield, relatively high content of alkaloids in similar Fritillaria, strong dise...

Claims

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Application Information

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IPC IPC(8): A61K36/8966
Inventor 骆军玉骆俊才
Owner 新疆伊禧堂生物科技有限公司
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