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Method for preparation of paclitaxel liposome by ethanol injection

An ethanol injection method and a technology of paclitaxel, applied in the field of manufacturing, can solve the problems such as serious physical and mental burden of patients, and achieve the effects of easy size, high yield and size control

Inactive Publication Date: 2014-04-23
丁小淇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyoxyethylene castor oil used in paclitaxel injection can cause a variety of side effects and bring serious physical and mental burden to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The method for preparing paclitaxel liposomes by ethanol injection method, the specific steps are as follows:

[0016] First, accurately weigh the target raw materials, then add cholesterol and soybean lecithin for injection;

[0017] Ultrasound for 3 minutes until it is completely dissolved;

[0018] Take a hot bath for 10 minutes;

[0019] Magnetic stirring at constant temperature for half an hour;

[0020] Inject chlorine gas;

[0021] It was filtered and concentrated, filtered on filter paper after constant volume, and the supernatant was discarded;

[0022] Add glucose powder, stir again, and centrifuge at high speed;

[0023] Take the precipitate and dry it.

[0024] The ethanol is absolute ethanol, and needs to be refrigerated for 12 hours before use.

[0025] The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Anyone familiar with the technical field within the tech...

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PUM

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Abstract

The invention discloses a method for preparation of a paclitaxel liposome by ethanol injection. The specific steps include: firstly, accurately weighing objective raw materials, then adding cholesterol and soybean phospholipid for injection; conducting ultrasonic wave for 3min till complete dissolution; performing heat bath to the mixture for at least 10min; carrying out magnetic stirring under a constant temperature for at least half an hour; injecting chlorine gas; carrying out filtration concentration and constant volume setting, then performing filtering on filter paper, and discarding the supernatant; adding glucose powder, performing stirring again, and conducting high speed centrifugation; taking the precipitate, and conducting drying, thus obtaining the paclitaxel liposome. The method provided by the invention has the advantages of: simple operation, easily controllable size and high yield, and is scientific and feasible.

Description

technical field [0001] The invention relates to the field of manufacture, in particular to a method for preparing paclitaxel liposomes by an ethanol injection method. Background technique [0002] Paclitaxel is a natural anti-tumor drug isolated and purified from Taxus genus. It is the first-line chemotherapy drug for ovarian cancer. It has also shown encouraging results in the treatment of breast cancer, lung cancer, leukemia, and gastrointestinal cancer. Efficacy. So far, it has been approved for marketing in 40 countries, and the main dosage forms on the market are paclitaxel injection and paclitaxel liposome. The polyoxyethylene castor oil used in paclitaxel injection can cause various side effects and bring serious physical and mental burden to patients. Therefore, scientists have been looking for better preparation methods to expand the application of paclitaxel, and the rapid development of liposomes provides a good application platform for insoluble anticancer drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/337A61P35/00
Inventor 丁小淇
Owner 丁小淇