A kind of nasal cavity cleaning care solution and preparation method thereof
A cleaning and solution technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of pigmentation, high toxicity of medicinal materials, neglecting the acceptance of nasal cleaning preparations, etc.
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Embodiment 1
[0075] Example 1: Take 10,000 g of fresh Houttuynia cordata, add 100,000 ml of water, and perform steam distillation. Collect 5,000 g of distillate (equivalent to 2 g of original medicinal materials per g). After filtration with a 0.45 μm filter membrane, add 50 g of Tween 80 and 1 g of benzalkonium. Ammonium bromide, 70g glycerol, 30g xylitol, 4780g purified water, after stirring, add 1.5g citric acid, 28g sodium citrate to adjust the pH to 6.0, add 40g sodium chloride to adjust the osmotic pressure to 290mOsm / kg, Stir well, filter with 0.22μm filter membrane, and distribute it in a special nasal washing device.
Embodiment 2
[0076] Example 2: Take 5000g of honeysuckle, add 100000ml of water, perform steam distillation, collect 5000g of distillate (equivalent to 1g original medicinal material per milliliter), filter by 0.45μm membrane, add 20g Tween 80, 0.1g benzalkonium chloride , 30g xylitol, 1g hyaluronic acid, 4856g purified water, stir well, add 17g sodium dihydrogen phosphate, 11g disodium hydrogen phosphate to adjust the pH to 5.8, add 65g sodium chloride to adjust the osmotic pressure to 300mOsm / kg, Stir well, filter with 0.22μm filter membrane, and dispense into nasal drops.
Embodiment 3
[0077] Example 3: Take 20,000g of mint, add 100,000ml of water, perform steam distillation, collect 5000g of distillate (equivalent to 4g original medicinal material per ml), filter by 0.45μm membrane, add 40g Tween 80, 0.8g benzalkonium bromide , 5g hyaluronic acid, 4845g purified water, stir well, add 1.5g citric acid, 30g sodium citrate to adjust the pH to 6.1, add 78g sodium chloride to adjust the osmotic pressure to 308mOsm / kg, stir well, use 0.22μm The filter membrane is sterilized and filtered, and then packed in nasal spray bottles.
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