A kind of nasal cavity cleaning care solution and preparation method thereof

A cleaning and solution technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of pigmentation, high toxicity of medicinal materials, neglecting the acceptance of nasal cleaning preparations, etc.

Active Publication Date: 2017-01-11
刘少华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 2. Neglect of user acceptance (i.e., compliance) of nasal wash preparations
For example: 1) Although the magnolia medicinal material selected has a definite curative effect, it is highly irritating to the nasal mucosa; 2) The extract of the compound decoction of traditional Chinese medicine is dark in color, and long-term use will cause pigmentation. bring discomfort
Therefore, the above situation often makes users give up using
[0010] 3. The selected medicinal materials are highly toxic
For example, Xanthii has nephrotoxicity, high dose or long-term use may induce respiratory, circulatory, and renal failure

Method used

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  • A kind of nasal cavity cleaning care solution and preparation method thereof
  • A kind of nasal cavity cleaning care solution and preparation method thereof
  • A kind of nasal cavity cleaning care solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Take 10,000 g of fresh Houttuynia cordata, add 100,000 ml of water, and perform steam distillation. Collect 5,000 g of distillate (equivalent to 2 g of original medicinal materials per g). After filtration with a 0.45 μm filter membrane, add 50 g of Tween 80 and 1 g of benzalkonium. Ammonium bromide, 70g glycerol, 30g xylitol, 4780g purified water, after stirring, add 1.5g citric acid, 28g sodium citrate to adjust the pH to 6.0, add 40g sodium chloride to adjust the osmotic pressure to 290mOsm / kg, Stir well, filter with 0.22μm filter membrane, and distribute it in a special nasal washing device.

Embodiment 2

[0076] Example 2: Take 5000g of honeysuckle, add 100000ml of water, perform steam distillation, collect 5000g of distillate (equivalent to 1g original medicinal material per milliliter), filter by 0.45μm membrane, add 20g Tween 80, 0.1g benzalkonium chloride , 30g xylitol, 1g hyaluronic acid, 4856g purified water, stir well, add 17g sodium dihydrogen phosphate, 11g disodium hydrogen phosphate to adjust the pH to 5.8, add 65g sodium chloride to adjust the osmotic pressure to 300mOsm / kg, Stir well, filter with 0.22μm filter membrane, and dispense into nasal drops.

Embodiment 3

[0077] Example 3: Take 20,000g of mint, add 100,000ml of water, perform steam distillation, collect 5000g of distillate (equivalent to 4g original medicinal material per ml), filter by 0.45μm membrane, add 40g Tween 80, 0.8g benzalkonium bromide , 5g hyaluronic acid, 4845g purified water, stir well, add 1.5g citric acid, 30g sodium citrate to adjust the pH to 6.1, add 78g sodium chloride to adjust the osmotic pressure to 308mOsm / kg, stir well, use 0.22μm The filter membrane is sterilized and filtered, and then packed in nasal spray bottles.

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Abstract

The invention discloses a care solution for cleaning a nasal cavity and a preparation method of the care solution. The care solution is prepared from 5,000 parts of traditional Chinese medicine distillate, 0.1-2 parts of preservatives, 1-100 parts of glyceryl polymethacrylate, 20-100 parts of tween 80, 30-80 parts of sodium chloride, 20-60 parts of a pH conditioning agent and 4658-4928.9 parts of purified water. The osmotic pressure of the care solution is 280-310mosm / Kg, and the pH value is 5.5-7.0. The preparation method of the care solution mainly comprises the following steps: by taking one or combination of houttuynia cordata, mint, honeysuckle and radix angelicae as raw materials, carrying out steam distillation to obtain the traditional Chinese medicine distillate; matching with auxiliary materials, and then filtering and carrying out split charging, so as to obtain the care solution. The solution disclosed by the invention has a strong inhibiting effect on nasal common microbe streptococcus infection, staphylococcus, bacillus influenza, influenza viruses and rhinoviruses, and can achieve the target of preventing rhinitis infection and recurrence.

Description

Technical field [0001] The invention relates to a cleaning and care preparation and a preparation method, in particular to a nasal cavity cleaning and care solution and a preparation method thereof. Background technique [0002] Everyone knows the importance of breathing to the maintenance of life. The first pass between the human body and the outside air is the nasal cavity. It is the first guardian of the human respiratory system and the only place where the human respiratory system exchanges substances with nature. . The nasal cavity is a long and narrow cavity with a narrow top and a wide bottom. It starts from the front nostril and ends at the back nostril, communicating with the nasopharynx. Most of the nasal cavity is covered by mucosa. The surface has cilia growing from ciliated cells. The cilia are covered with a layer of mucus secreted by goblet cells and other secretory cells, forming a layer on the mucosal surface that moves backward with the cilia. The mucus blanke...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/232A61K36/355A61K36/534A61K36/78A61K47/34A61P11/02A61P11/00
Inventor 刘少华
Owner 刘少华
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