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Microencapsulated preparation for protecting eyesight and preparation method thereof

A technology of microencapsulation and preparation, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve the problems of low bioavailability and single formula, and achieve high bioavailability and uniform color. Long-lasting and stable effect

Inactive Publication Date: 2014-04-23
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These products have a single formula, low bioavailability, and the finished dosage forms are soft capsules, which have obvious limitations for children, the elderly and other people who have difficulty swallowing

Method used

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  • Microencapsulated preparation for protecting eyesight and preparation method thereof
  • Microencapsulated preparation for protecting eyesight and preparation method thereof
  • Microencapsulated preparation for protecting eyesight and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 compound lutein solid granule

[0038] formula:

[0039]

[0040] Preparation process: ①Add OSA modified starch, maltodextrin, sodium ascorbate and ascorbyl palmitate into 575ml of water at 50°C, stir and dissolve to obtain an aqueous phase solution; ②At 45°C, mix mixed tocopherols, sunflower Phospholipids and lutein crystals (purity 65%) were added to perilla seed oil, stirred and dissolved to obtain an oil phase solution; ③The water phase solution and the oil phase solution were mixed and emulsified for 5 hours, and the obtained emulsion was subjected to 20Mpa high pressure homogenization and spray drying to obtain cold water dispersion Type compound lutein-α-linolenic acid microcapsule powder, prepared into a compound lutein solid granule with a packaging specification of 4g / bag, and the dosage is 1 bag per day.

Embodiment 2

[0041] Example 2 Compound Lutein Ester Solid Granules

[0042] formula:

[0043]

[0044]

[0045] Preparation process: Same as in Example 1, the crystal purity of lutein ester is 80%, and the compound lutein ester solid granule is finally obtained, the packaging specification is 1g / bag, 1 bag per day.

Embodiment 3

[0046] Embodiment 3 Compound Lutein Ester Tablets

[0047] formula:

[0048]

[0049] Preparation process: The microencapsulation production process is the same as in Example 1, and the purity of lutein ester crystals is 80%. The prepared microcapsules are mixed with mannitol, vitamin C, calcium hydrogen phosphate, magnesium stearyl, polyethylene glycol, anhydrous citric acid and aspartame, and then granulated, dried, granulated, mixed and pressed into tablets The finished product is prepared, the specification is 1g / tablet, and the daily dosage is 4 tablets.

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Abstract

The invention relates to a microencapsulated preparation for protecting eyesight and a preparation method thereof. The preparation essentially comprises a microencapsulated effective component consisting of lutein and alpha-linolenic acid. The preparation method comprises the following steps: respectively preparing an oil phase solution and an aqueous phase solution; mixing and emulsifying the solutions to prepare emulsion, or further drying to prepare particles. Match of lutein and alpha-linolenic acid is an important contribution of the invention, both lutein and alpha-linolenic acid can be used for protecting eyesight, and alpha-linolenic acid can be used for transferring lutein to macula lutea, so that the effect of relieving asthenopia and protecting eyesight of the product can be greatly improved. The preparation can be used for preparing solid electuary, liquid preparation, tablet candy or preparations in other modes for relieving asthenopia and protecting eyesight according to requirements.

Description

technical field [0001] The invention relates to a microencapsulated preparation for protecting eyesight and a preparation method thereof. Background technique [0002] Eye health is a persistent and important topic, and people's attention to eye health has never stopped. At present, the sharp increase in the number of elderly people in China, the deterioration of the environment, the increase in the pressure of life, and the acceleration of the pace of the times have exacerbated the occurrence and development of eye diseases. There are a variety of eye care products on the market, and companies have introduced more natural or synthetic substances or trace elements to help consumers prevent or treat various eye discomforts or eye diseases, such as cataracts, age-related macular degeneration, myopia , visual fatigue, etc. In fact, some of these products have unsatisfactory effects due to technical and scientific flaws in formulas. [0003] Among all eye protection ingredien...

Claims

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Application Information

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IPC IPC(8): A61K36/535A61K36/55A61K36/52A61K36/185A61K47/44A61P27/02A61K31/047
Inventor 吴文忠高杰王建华陈剑彬马俊杰隋海澜
Owner INNOBIO CORP LTD
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