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Treating skin exposed to uv radiation with quetiapine or analogs thereof

A technology of quetiapine and analogues, which is applied in the treatment of skin cancer and photoaging, and can solve the problems of existing risks, expensive soft tissue fillers and laser surgery, retinoid dermatitis, etc.

Inactive Publication Date: 2014-04-23
UNIVERSITY OF MANITOBA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Protective clothing can be expensive and may be unwanted by subjects
Use of topical retinoids may result in retinoid dermatitis in subjects and may not be well tolerated by all subjects
The use of botulinum toxin, soft tissue fillers and laser surgery is expensive and also potentially risky

Method used

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  • Treating skin exposed to uv radiation with quetiapine or analogs thereof
  • Treating skin exposed to uv radiation with quetiapine or analogs thereof
  • Treating skin exposed to uv radiation with quetiapine or analogs thereof

Examples

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Effect test

example 1

[0078] Anti-aging effect of quetiapine on skin

[0079] Ultraviolet (UV) radiation is responsible for a number of acute and chronic deleterious skin effects. The two most important consequences are skin cancer and photoaging. Photoaging caused by UV radiation substantially accelerates the natural aging process by damaging collagen, the major component of connective tissue in the skin. Oxidative stress has a centrally important role in these processes. Antioxidants have become an important supplementary approach to conventional sunscreens to protect the skin from UV-induced damage. The aim of this study was to examine whether the antipsychotic drug quetiapine can protect dermal fibroblasts from damage caused by UV radiation by reducing oxidative stress.

[0080] The mechanism of action that makes quetiapine an effective therapy is fairly well known. The potential of quetiapine to be used for its antioxidant properties is less well known. Part of the drug's effectiveness ma...

example 2

[0094] Effects of quetiapine treatment on UV-exposed skin

[0095] Purpose

[0096] To conduct a small pilot study to examine the effects of quetiapine treatment on the skin of hairless mice to determine whether it could prevent damage associated with chronic UV exposure.

[0097] subjects

[0098] Ten female SKH-1 mice were obtained from Jackson Laboratories. They were 9 weeks old at the start of the experiment.

[0099] method

[0100] Animals were ordered at 7 weeks of age and half were pretreated with quetiapine (10 mg / kg, dissolved in drinking water) for two weeks prior to initiation of UV exposure. Leave the other half untouched. Quetiapine was obtained in powder form (batch 1677) from Avlon Works, Bristol, England (site of manufacture of AstraZeneca Pharmaceuticals). All mice were exposed three times a week for a total of 10 weeks. The exposure intensity was 90 mJ / cm and the exposure duration was 7.5 minutes. In the literature, this intensity and duration of exp...

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Abstract

The present invention includes methods for treating sun-exposed skin, such as treating photoaging and treating skin cancer. Also included are methods for altering a cell's response to ultraviolet radiation. The methods include administration of quetiapine or an analog thereof or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application Serial No. 61 / 485,908, filed May 13, 2011, which is hereby incorporated by reference. Background technique [0003] Topical application of antioxidants is a promising therapy to prevent damage caused by excess reactive oxygen species (ROS). There are also a variety of products being researched with antioxidant properties, including vitamin C, vitamin E, beta carotene, caffeic acid, isoflavones, flavonoids, polyphenols, selenium, and zinc. These antioxidants often have the unwanted characteristics of instability and cosmetically unpleasant tint, which makes their use difficult. [0004] Current solutions to prevent or repair skin damaged by UV radiation include the use of sunscreens, protective clothing engineered to filter out UVA and UVB, topical retinoids that are vitamin A derivatives and have anti-aging properties Alcohol, Botox injections and soft t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/554A61K8/49A61P17/00A61P35/00A61Q17/04A61Q19/08
CPCA61K8/49A61Q17/04A61K31/554A61Q19/08A61K2800/92A61P17/00A61P35/00
Inventor X-M.李J.孔H.张K.哈特尔
Owner UNIVERSITY OF MANITOBA