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Traditional Chinese medicinal composition for treating psoriasis and preparation and application thereof

A pharmaceutical preparation and composition technology, applied in the field of traditional Chinese medicine composition for the treatment of psoriasis, can solve the problems of skin cell corrosion, human injury, and high requirements for patients' own conditions, and achieve the advantages of simple preparation method, good safety and remarkable curative effect Effect

Active Publication Date: 2014-05-14
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used external medicines include mustard gas, coal tar, anthranol, and calcipotriol. These medicines are strong cytotoxic medicines, which have a strong corrosive effect on normal skin cells. Improper use can easily cause harm to the human body. And with the strict management of toxic agents, the source of raw materials for this type of drug has also become a very serious problem
New antibody-based biological agents such as etanercept and infliximab have also begun to be used in the treatment of some severe psoriasis, but these agents have strict indications and high requirements for patients' own conditions, and biological agents The long-term adverse reactions and side effects have yet to be further clarified, and the high price also limits its wide application in clinical practice.
[0004] Traditional Chinese medicine has unique advantages and characteristics in the treatment of psoriasis, but most of the Chinese patent medicines on the market for the treatment of psoriasis are large compound prescriptions, which contain a wide variety of medicinal flavors. For example, the commercially available "Compound Qingdai Capsule" contains 14 traditional Chinese medicines , "Yinxieling Granules" contains 12 traditional Chinese medicines, and the taste of medicines increases, which not only increases the cost, but also increases the risk of toxic and side effects

Method used

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  • Traditional Chinese medicinal composition for treating psoriasis and preparation and application thereof
  • Traditional Chinese medicinal composition for treating psoriasis and preparation and application thereof
  • Traditional Chinese medicinal composition for treating psoriasis and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: preparation pharmaceutical composition of the present invention

[0027] Get respectively by weight parts:

[0028]

[0029] Put the above composition in a container, add water until the water surface is 2 to 3 cm higher than the surface of the medicinal material, decoct twice with a slow fire, the first time for 1 hour, and the second time for 0.5 hours, combine the two extracts, concentrate to a relative density of 1:1, That is, oral liquid medicine is obtained.

Embodiment 2

[0030] Embodiment 2: the optimal extraction process of Chinese medicine composition of the present invention

[0031] The concrete formula of Chinese medicine composition of the present invention is:

[0032] Scutellaria baicalensis 30g, Xu Changqing 30g, salvia miltiorrhiza 15g, astragalus membranaceus 20g, black plum 9g, weigh 9 parts in parallel.

[0033] Orthogonal experiment design was used to optimize the optimal extraction process of the prescription.

[0034] (1) Extraction process conditions and investigation plan

[0035] Taking the content of baicalin and paeonol in the extract and the yield of the extract as indicators, L 9 (3 4 ) Orthogonal test to investigate the influence of factors such as water addition times, extraction time, extraction times, and alcohol precipitation concentration on the extraction effect in the extraction of medicinal materials, so as to optimize the optimal extraction process. See Table 1 for the levels of each factor.

[0036] Table...

Embodiment 3

[0053] Embodiment 3: Chinese medicine compound extract of the present invention

[0054] Take 600g of Scutellaria baicalensis, 600g of Xu Changqing, 300g of Salvia miltiorrhiza, 400g of Astragalus membranaceus, and 180g of ebony plum, add 8 times the volume of water and decoct twice as usual, each decocting for 1.5h, combine the extracts, filter, and concentrate the filtrate to a relative density of 1: 1.08~1.10 (90-95°C), after cooling to room temperature, add 95% ethanol to adjust the ethanol concentration to 70%, let it stand at 4°C for 24 hours, filter, and recover ethanol from the filtrate under reduced pressure, continue to concentrate until the relative density is 1: 1.25-1.30 (50-60°C) to obtain the extract, then dry the extract under reduced pressure at 60°C and 1Mpa to obtain 190g of dry extract.

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Abstract

The invention relates to the technical field of medicine, provides a traditional Chinese medicinal composition for treating psoriasis. The traditional Chinese medicinal composition comprises the following raw materials in parts by weight: 9-60 parts of Scutellaria baicalensis, 6-45 parts of cynanchum paniculatum, 6-30 parts of Salvia miltiorrhiza, 12-45 parts of Astragalus membranaceus, and 3-15 parts of smoked plum. The invention also provides a preparation and an extraction process of the traditional Chinese medicinal composition. Among 30 psoriasis vulgaris patients treated with the traditional Chinese medicinal composition for 12 weeks, the total effective rates in treatment group and control group are 72.4% and 26.7%, respectively, resulting in statistically significant difference.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for treating psoriasis and its preparation and application. Background technique [0002] Psoriasis is a chronic and recurrent skin disease, the etiology and pathogenesis of psoriasis are still not fully understood. [0003] At present, the treatment of this disease mostly adopts comprehensive therapy such as oral administration, topical application combined with photochemical (PUVA) treatment, but there are major problems in all of them. Oral drugs such as vitamin A acids, corticosteroids or drugs that inhibit epidermal cell division (methotrexate, etc.) all have relatively large liver and kidney toxicity and side effects, and relapse is very easy after drug withdrawal. Commonly used external medicines include mustard gas, coal tar, anthranol, and calcipotriol. These medicines are strong cytotoxic medicines, which have a strong corros...

Claims

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Application Information

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IPC IPC(8): A61K36/736A23L1/29A61P17/06A23L33/00
Inventor 刘继勇顾清高申吴建华虞慧华尤本明潘勇华
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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