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Method for improving polypeptide membrane flexibility by adopting poly trimethylene carbonate and PTMG

A technology of polytetrahydrofuran ether glycol and polytrimethylene carbonate, which is applied in the field of polymer film preparation, can solve the problems of lack of flexibility and stiffness of polypeptide films, and achieve easy mastery, improved flexibility, and simple operation Effect

Inactive Publication Date: 2014-05-28
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide is relatively stiff, and the polypeptide film lacks good flexibility, so to a certain extent limit its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of polypeptide-polytrimethylene carbonate graft copolymer:

[0015] Add 12 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 3.1 grams of polytrimethylene carbonate monolauryl ether with a molecular weight of 1000, and 0.9 grams of p-toluene in the dry reactor. Sulfonic acid, then add 260 ml of 1,1,2-trichloroethane solvent, under an inert atmosphere, stir and react at 55°C for 3 days, terminate the reaction, and then obtain the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of Polypeptide Film Modified by Polytrimethylene Carbonate and Polytetrahydrofuran Ether Diol:

[0017] Add 10 grams of polypeptide-polytrimethylene carbonate graft copolymer and 38 milliliters of 1,1,2-trichloroethane solvent into the drying reactor, and add polytetrahydrofuran ether accounting for 1% of the total weight of the modified membrane Diol (molecular weight: 4000), stirred and mixed at 40°C for 50 minutes under an inert atmo...

Embodiment 2

[0020] 1) Synthesis of polypeptide-polytrimethylene carbonate graft copolymer:

[0021] Add 12 grams of poly(r-ethyl-L-glutamate) with a molecular weight of 70,000, 5.3 grams of polytrimethylene carbonate monolauryl ether with a molecular weight of 1500, and 0.91 grams of p-toluenesulfonate in the dry reactor. acid, then add 230 ml of 1,1,2-trichloroethane solvent, under an inert atmosphere, stir and react at 56°C for 4 days, terminate the reaction, and then obtain the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of Polypeptide Film Modified by Polytrimethylene Carbonate and Polytetrahydrofuran Ether Diol:

[0023] Add 10 grams of polypeptide-polytrimethylene carbonate graft copolymer and 36 milliliters of 1,1,2-trichloroethane solvent into the drying reactor, and add polytetrahydrofuran ether accounting for 2% of the total weight of the modified membrane Diol (molecular weight: 4500), stirred and mixed at 45°C for 60 minutes under an inert atmo...

Embodiment 3

[0026] 1) Synthesis of polypeptide-polytrimethylene carbonate graft copolymer:

[0027] Add 12 grams of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 7.2 grams of polytrimethylene carbonate monolauryl ether with a molecular weight of 2000, and 1.03 grams of p-toluenesulfonate in the dry reactor acid, then add 177 ml of dimethyl sulfoxide, under an inert atmosphere, stir and react at 58°C for 3 days, terminate the reaction, and then obtain the target product by filtration, dialysis, and drying;

[0028] 2) Preparation of Polypeptide Film Modified by Polytrimethylene Carbonate and Polytetrahydrofuran Ether Diol:

[0029] Add 10 grams of polypeptide-polytrimethylene carbonate graft copolymer and 35.5 milliliters of dimethyl sulfoxide in the drying reactor, add the polytetrahydrofuran ether glycol (molecular weight is 5000 ), under an inert atmosphere, stirred and mixed at 50°C for 70 minutes, formed a film by casting method, and dried in a vacuum oven at 50°C to ...

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PUM

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Abstract

The invention discloses a method for improving polypeptide membrane flexibility by adopting poly trimethylene carbonate and PTMG. The method comprises the following steps: (1) synthesis of the polypeptide-poly trimethylene carbonate graft copolymer: adding polypeptide homopolymer, poly trimethylene carbonate single dodecyl ether, a solvent and a catalyst into a dry reactor, under the inert atmosphere, and stirring for reaction for 3-4 days at the temperature of 55-58 DEG C, so that the target product is obtained through filtering, dialyzing and drying; (2) preparation for the polypeptide membrane modified by the poly trimethylene carbonate and the PTMG: adding the polypeptide-poly trimethylene carbonate graft copolymer, PTMG and a solvent into the dry reactor, under the inert atmosphere, stirring and mixing for 50-70 min at the temperature of 45-50 DEG C, forming the membrane through tape casting, and drying, so that the target product is obtained. The method has the advantages that the preparation technology is simple and easy to master, and the flexibility of the modified membrane is improved greatly.

Description

technical field [0001] The invention relates to a method for improving the flexibility of a polypeptide film, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide is relatively stiff and lacks good flexibility, so to a certain extent limits its application. Polytrimethylene carbonate and polytetrahydrofuran ether glycol have better biocompatibility and biodegradability, are relatively soft and have better blendability with each other. First, the polytrimethylene carbonate segment is introduced into the polypeptide segment to form a polypeptide-polytrimethylene carbonate graft copolymer to improve the blendability of the polypeptide, and then the polytetrahydrofuran ether glycol segment is added to the polypeptide The peptide-polytrimethylene carbonate graft copolymer forms a blend to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L87/00C08L71/02C08G81/00
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH