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A kind of chitosan and polybenzyl glutamate graft copolymer and preparation method thereof

A technology of poly(benzyl glutamic acid) and graft copolymer is applied in the directions of pharmaceutical formulations, pharmaceutical combinations, and non-active ingredients medical preparations, etc., and can solve the problem of high cost

Inactive Publication Date: 2016-04-13
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of them react under strong alkali conditions, and the chitosan molecular chain is broken during the reaction process. At the same time, these reactions are mostly carried out in isopropanol solvent, and the cost is relatively high.

Method used

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  • A kind of chitosan and polybenzyl glutamate graft copolymer and preparation method thereof
  • A kind of chitosan and polybenzyl glutamate graft copolymer and preparation method thereof
  • A kind of chitosan and polybenzyl glutamate graft copolymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Add 5g of chitosan to 250g of N,N-dimethylformamide, stir until completely dissolved, then add 13.8g of phthalic anhydride, react at about 125°C for 15 hours, precipitate in ice water, and extract with ethanol Purified and vacuum dried to obtain 8 g of phthalylated chitosan. figure 1 Curve a in is the infrared spectrogram of chitosan, figure 1 Curve b in is the infrared spectrum of phthalylated chitosan. As can be seen from comparative analysis, in the infrared spectrum of phthalylated chitosan, the C=O vibration of the amides formed by the phthalylated amino group on chitosan is at 1712 cm -1 A strong absorption peak appeared, and due to the formation of the imide structure, the interaction of two adjacent carbonyl groups split it into two peaks, one of which appeared at a higher frequency of about 1777cm -1 nearby. figure 2 is phthalylated chitosan 1 H-NMR spectrum, 7.0-8.0ppm is hydrogen on phthaloyl group, chitosan skeleton hydrogen is 1.8-5.0ppm, solvent D...

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Abstract

The invention discloses a chitosan-polybenzyl glutamate graft copolymer having a chemical structural formula as shown in a formula (I), and also a preparation method of the copolymer. The chitosan reacts with the phthalic anhydride to obtain phthaloyl chitosan, next, the phthaloyl chitosan reacts with bromoacetyl bromide to introduce a bromine end group, the bromine end group reacts with sodium azide to introduce an azide group, and then the phthaloyl chitosan with the azide group reacts with the polybenzyl glutamate with an acetylene end group to obtain the chitosan-polybenzyl glutamate graft copolymer. The after-treatment of the product is simple.

Description

technical field [0001] The invention relates to a graft copolymer of chitosan and polybenzyl glutamate and a preparation method thereof. Background technique [0002] In the drug controlled release system, besides the drug itself, the drug carrier also plays an important role. Generally speaking, the drug carrier is acted by polymer materials, including natural polymer materials, semi-synthetic polymer materials and synthetic polymer materials. These polymer materials can be used in different controlled release systems according to different functions, such as gel controlled release, microspheres and microcapsules controlled release, in vivo embedded controlled release, transdermal controlled release, targeted controlled release, etc. . The application of biodegradable materials to drug sustained-release systems is an important frontier subject field arising from the interpenetration of modern pharmaceutical science, biological science, and polymer science. In this field,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00C08B37/08A61K47/34A61P35/00
Inventor 黄梅芳钱国平刘宏富方薇付其林谢晶巨锁基姜旺恒
Owner CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY