Rosuvastatin calcium oral composition for increasing dissolution rate and preparation method of composition

Abstract

The invention relates to a rosuvastatin calcium oral composition for increasing dissolution rate and a preparation method of the composition. The composition is characterized by mainly comprising the following components in parts by weight: 0.5 part of rosuvastatin calcium, 0.02-0.05 part of solubilizer, 0.20-0.40 part of binder, 3.00-5.0 parts of filler, 0.01-0.1 part of lubricant and 0.30-1.5 parts of disintegrating agent. The preparation provided by the invention improves the dissolution rate of the medicines, so that the clinical curative effect is improved.

Description

field of invention [0001] The invention relates to the field of chemical pharmacy, in particular to an oral preparation of rosuvastatin calcium with increased dissolution rate and a preparation method thereof. Background of the invention [0002] Cardiovascular disease is one of the most common and serious diseases that endanger human health (especially middle-aged and elderly people). Dyslipidemia is an important risk factor for atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular diseases. Lipid-lowering drugs can reduce these The incidence and mortality of diseases have a positive and far-reaching impact on the prevention and treatment of cardiovascular diseases. With the advent of the aging population, the proportion of hypertension and other diseases caused by hyperlipidemia in the cardiovascular diseases of the elderly is increasing year by year, which seriously threatens people's life safety. Therefore, seeking effective, safe and reli...

AI Technical Summary

Problems solved by technology

Even though rosuvastatin has such a strong advantage, its adverse reactions are more serious than other statins. In the clinical trial before marketing, 7 patients in the high-dose (80mg) group had life-threatening events. Rhabdomyolysis, so its safety was questioned at the time

In pre-marketing clinical trials, it was also found that rosuvastatin can also damage the renal function of some patients (no similar adverse reactions of other statins have been observed)

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