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A medicine extract product used for preventing and/or treating senile dementia, a preparing method thereof, preparations thereof and applications thereof

A technology for Alzheimer's disease and its extract, which is applied in the field of drug extracts for preventing and/or treating Alzheimer's disease and their preparation, can solve the problems of single indication, inferior to the comprehensive adjustment ability of traditional Chinese medicine, etc., and achieves convenient use and improved recognition. Excellent cognitive ability and curative effect

Inactive Publication Date: 2014-06-25
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The effect of chemical drugs is relatively direct, but the indications are usually relatively single, not as strong as the comprehensive adjustment ability of traditional Chinese medicine

Method used

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  • A medicine extract product used for preventing and/or treating senile dementia, a preparing method thereof, preparations thereof and applications thereof
  • A medicine extract product used for preventing and/or treating senile dementia, a preparing method thereof, preparations thereof and applications thereof
  • A medicine extract product used for preventing and/or treating senile dementia, a preparing method thereof, preparations thereof and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 60kg of treated scutellaria scutellaria, 40kg of Manshanxiang, 60kg of ginkgo biloba leaves, and 10kg of Panax notoginseng; add 340kg of water, soak at 10°C for 5 hours; then decoct 4 times, each time for 3 hours, and combine the decoction liquid , filter with a filter bag; add ethanol to the filtered decoction until the ethanol content in the decoction is 60%, let it stand for 30 hours, filter with a filter membrane, and recover ethanol by thermal evaporation; the filtrate after recovering ethanol Combining microwave drying and moisture absorption drying under normal pressure conditions to obtain powdery drug extracts.

Embodiment 2

[0040]Take 50.5kg of processed Erigeron breviscapus, 50.5kg of Manshanxiang, 555kg of ginkgo biloba leaves, and 20kg of Panax notoginseng, mix them; add 530kg of water, soak at 30°C for 3 hours; then decoct 3 times, each time for 2 hours, and combine Boil the liquid, filter it with a filter bag; add ethanol to the filtered decocting liquid until the ethanol content in the decocting liquid is 70%, let it stand for 24 hours, filter it with a filter membrane of 0.45 ~ 15 μm, and recover ethanol by membrane method; The filtrate after recovery of ethanol is microwave-dried under normal pressure conditions to obtain powdery drug extract.

Embodiment 3

[0042] Take 40kg of processed scutellaria breviscapus, 60kg of Manshanxiang, 40kg of ginkgo biloba leaves, and 30kg of Panax notoginseng, mix them; add 850kg of water, soak at 25°C for 4 hours; then decoct 4 times, each time for 2 hours, and combine the decoction liquid , filter with a 0.3μm filter bag; add ethanol to the filtered decoction until the ethanol content in the decoction is 80%, let it stand for 20h, and use a 0.45~1.2μm mixed cellulose ester microporous filter membrane Filtration, recovery of ethanol by thermal evaporation; freeze-drying the filtrate after recovery of ethanol under reduced pressure to obtain powdery drug extract.

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Abstract

The invention discloses a medicine extract product used for preventing and / or treating senile dementia, a preparing method thereof, preparations thereof and applications thereof. The medicine extract product is prepared by blending following raw material medicines by weight: 400-600 parts of herba erigerontis, 400-600 parts of gaultheria cumingiana, 400-600 parts of ginkgo leaf and 100-300 parts of pseudo-ginseng, extracting with water, performing alcohol precipitation, concentrating and drying. Powder, tablets, granules, capsules, pills and injections can be prepared by adding pharmaceutically acceptable accessory materials into the medicine extract product. The applications are applications in preparation of medicines preventing and / or treating the senile dementia. Tests prove that: the medicine extract product can significantly improve cognitive ability and physical performance of senile dementia patients, effectively relive clinical symptoms caused by qi-stagnation and blood stasis of the patients, largely shorten the P300 incubation period in different parts of the patients, and reduce the LDL-C (low density lipoprotein) level and the TC (total cholesterol) level of cerebral infarction patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a medicine extract for preventing and / or treating senile dementia and its preparation method, preparation and application. Background technique [0002] Alzheimer's disease is a mental impairment syndrome that occurs in the early and old age and is characterized by brain dysfunction characterized by progressive dementia. Including senile dementia, also known as Alzheimer's disease (Alzheimer disease, AD for short) and cerebrovascular dementia (Vascular dementia, VD for short). Among them, AD is a primary central nervous system degenerative disease that occurs in middle-aged and elderly people; VD is dementia caused by brain damage caused by cerebrovascular disease. The etiology of VD involves two aspects, namely, cerebrovascular disease and risk factors. Risk factors include risk factors for cerebrovascular disease (hypertension, hyp...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61P25/28
Inventor 普俊学杨兆祥吴琼粉张友云
Owner KPC PHARM INC
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