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Method for inspecting quality of haemorrhoids suppository

A hemorrhoid suppository and quality technology, which is applied in the field of quality detection of traditional Chinese medicines for external use, can solve the problems of complex, negative chromatographic interference of thin-layer identification of Scutellaria baicalensis medicinal materials, difficult to control the quality of medicines and the like, and achieves the effect of eliminating interference and improving the quality of medicines.

Inactive Publication Date: 2014-06-25
GUIYANG UNIV
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Problems solved by technology

[0003] At present, the detection of baicalin in Scutellaria baicalensis by hemorrhoid suppositories is not only complicated, but also interferes with the negative chromatogram of the TLC identification of Scutellaria baicalensis, making it difficult to control the quality of the drug

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  • Method for inspecting quality of haemorrhoids suppository
  • Method for inspecting quality of haemorrhoids suppository
  • Method for inspecting quality of haemorrhoids suppository

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Embodiment Construction

[0021] Below in conjunction with specific embodiment, the inventive method and beneficial effect are further described:

[0022] 1) Identification

[0023] 1.1) Preparation of identification solution: take 0.2g of chopped hemorrhoid suppository, add 5ml of methanol, ultrasonically treat (power 250W, frequency 40kHz) for 15 minutes, filter, and use the filtrate as the test solution for identification;

[0024] Another suppository lacking gallnut was taken, cut into pieces, weighed 0.2 g, and made into a negative solution for identification by the same method;

[0025] In addition, 0.5 g of Gallatia chinensis reference medicinal material was taken, and the same method was used to prepare the reference medicinal material solution for identification;

[0026] Then take the gallic acid reference substance, add methanol to make a reference substance solution for identification containing 1 mg of gallic acid per ml;

[0027] 1.2) Identify according to thin-layer chromatography (App...

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Abstract

The invention discloses a method for inspecting the quality of a haemorrhoids suppository. The method comprises steps of identifying and measuring the content, wherein the step of identifying comprises a step of identifying a thin-layer chromatography of Chinese galls in the haemorrhoids suppository, wherein a Chinese gall reference medicine material and a nutgall acid reference substance are taken as reference materials, and trichloromethane-ethyl formate-formic acid is taken as a developing solvent; the step of measuring the content comprises a step of detecting berberine in the haemorrhoids suppository, namely, measuring by adopting a high-performance liquid chromatography method taking a berberine reference substance as a reference material and a solution prepared from a acetonitrile-0.1% phosphoric acid solution (every 100ml of the solution contains 0.1g of sodium dodecyl sulfate) as a mobile phase. The method has the advantages of sensitivity, stability, reliability and the like, the defect that the thin-layer identification negative chromatography of scutellaria baicalensis can cause interference is effectively eliminated, a system is high in suitability, linear relation, precision degree, sample stability and repeatability and sample feeding recycling rate, and the quality of a medicine can be accurately reflected, so that the quality of the medicine can be effectively controlled.

Description

technical field [0001] The invention relates to a method for detecting the quality of externally used traditional Chinese medicines, in particular to a method for detecting the quality of hemorrhoid suppositories. Background technique [0002] Hemorrhoid suppository is a kind of external use traditional Chinese medicine for treating hemorrhoids. The applicant has filed a patent application on March 12, 2014 (application number is 201410088628.1); 10. Galla japonica 10-12, Sophora flavescens 1-3; its preparation method is to use ethanol to reflux extract the active ingredients in Phellodendron chinensis, and the remaining three medicinal materials are extracted by the method of water extraction and alcohol precipitation, and the two parts of the extract are combined and concentrated to a liquid state. extract; then the fluid extract is mixed with the matrix PEG1000 (38%), PEG4000 (59%), PEG6000 (3%) melted in a hot bath at a weight ratio of 4:6 and then injection-molded to fo...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 武孔云
Owner GUIYANG UNIV
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