Soluble hyaluronic acid micro-needle patch

A technology of hyaluronic acid and microneedle patch, which is applied in the field of skin care products to achieve the effect of good biocompatibility, increased fluidity and high safety

Active Publication Date: 2014-07-02
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to overcome the insufficient mechanical strength of the microneedles prepared by using hyaluronic acid with a smaller molecular weight in the preparation of hyaluronic acid microneedles in the above prior art, it is not conducive to Piercing into the skin, the use of hyaluronic acid with high molecular weight is not conducive to the preparation and shaping of microneedles. The present invention provides a microneedle that can enhance the mechanical strength of microneedles prepared with hyaluronic acid with a smaller molecular weight, which is conducive to skin penetration and Soluble hyaluronic acid microneedle patch formed by hyaluronic acid microneedle with high molecular weight

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Influence of hyperbranched polysulfone amine group hyaluronic acid molecular weight

[0034] The experiment was divided into four groups from 1 to 4. First, take four parts of hyperbranched polysulfone amine (molecular weight: 20kDa), 2g each, and dissolve them in 50g of water for injection under stirring at 30°C, then take 10g of hyaluronic acid with four different molecular weights, each with a molecular weight of 10kDa , 400 kDa, 1000 kDa and 1500 kDa, respectively marked as 1, 2, 3, 4 groups, respectively slowly, while stirring, add the water dissolved in hyperbranched polysulfone amine, then add Vc glycoside 0.2g, 30 ℃ Stir until completely dissolved to obtain a clear solution. Vacuumize the solution to remove air bubbles to obtain the injection molding solution. Pour the above solution into a microneedle mold containing a large number of conical microholes. The diameter of the bottom of the conical hole is 300 μm and the depth is 600 μm. Then the micro...

Embodiment 2

[0037] Embodiment 2 The influence of hyperbranched polysulfone amine adding amount

[0038] There were 6 groups in the experiment, of which the first group was the negative control group, that is, no hyperbranched polysulfone amine was added, and the remaining five groups were added with different amounts of hyperbranched polysulfone amine (molecular weight 20kDa). The specific operation is as follows, six parts of 50g water for injection are added with different amounts of hyperbranched polysulfone amine, the weights are respectively 0g, 0.1g, 0.5g, 1.0g, 2.0g and 3.0g, respectively marked as 1, 2, 3, Groups 4, 5, and 6 were dissolved completely under stirring at 40°C, and then slowly added 10 g of hyaluronic acid (molecular weight 100 kDa) while stirring, and 0.2 g of Vc glycoside respectively. . Pour the above solution into a microneedle mold containing a large number of conical micropores. The diameter of the bottom edge of the conical hole is 300 μm, and the depth is 600...

Embodiment 3

[0041] The influence of embodiment 3 hyperbranched polyester group hyaluronic acid molecular weight

[0042]The experiment was divided into four groups from 1 to 4. First, take four parts of hyperbranched polyester (molecular weight 5kDa, containing hydroxyl groups at the end), each 1g, dissolve in 50g water for injection under stirring at 50°C, and then take four hyaluronic acids with different molecular weights 10g each, molecular weight They are 20kDa, 500 kDa, 1500 kDa and 2500 kDa, respectively, recorded as 1, 2, 3, 4 groups, respectively, slowly, while stirring, add the water dissolved in hyperbranched polysulfone amine, and then add 0.1g bearberry respectively Glycoside, stirred at 50°C until completely dissolved to obtain a clear solution. Vacuumize the solution to remove air bubbles to obtain the injection molding solution. Pour the above solution into a microneedle mold containing a large number of conical microholes. The diameter of the bottom of the conical hole ...

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Abstract

The invention relates to the technical field of skin-care products, and particularly relates to a soluble hyaluronic acid micro-needle patch. The patch comprises a micro-needle array and a base, and is prepared from the following raw materials in percentage by weight: 75-98.7 percent of hyaluronic acid or salt thereof, 0.8-24.5 percent of hyperbranched polymer and 0.5-24.2 percent of functional active component, wherein the hyperbranched polymer contains active amino or hydroxy at the terminal, and can be dissolved in water and biodegradable; the viscosity of the hyaluronic acid aqueous solution can be remarkably reduced due to addition of the hydroxy or amino terminated hyperbranched polymer, the fluidity is increased, and the hyaluronic acid aqueous solution can be cast into a film and injected into micropores of a die conveniently; a remarkable effect can be achieved when a little amount of the hyperbranched polymer is added, and the selected hyperbranched polymer is biodegradable, so that the prepared hyaluronic acid micro-needle has high safety and good biocompatibility; furthermore, pressure injection molding is adopted during mold injection, and the hyaluronic acid aqueous solution can be smoothly injected into micropores of a die.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a soluble hyaluronic acid microneedle patch. Background technique [0002] Anti-aging is a woman's life's work. With age, the skin will inevitably become loose, dry lines, crow's feet, nasolabial folds, etc. will appear. Due to the barrier function of the stratum corneum of the skin, it is difficult for the active ingredients of general anti-wrinkle skin care products to absorb into the basal layer of the epidermis and the dermis to exert the anti-wrinkle effect. In recent years, microneedle beauty is becoming more and more popular, and it is a very fashionable beauty method now. [0003] Microneedles can pierce the skin and form microchannels in the stratum corneum, and the beauty active ingredients can reach the deep layer of the epidermis along the microchannels and diffuse into the dermis. Due to the elasticity of the skin and the tiny size of the microneedle ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/73A61K8/85A61K8/84A61Q19/08A61Q19/00
Inventor 刘建建郭学平杨莹莹冯晓毅李超张燕耿凤
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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