Ethosome gel film-coating agent with multiple wound repair effects and preparation method of ethosome gel film-coating agent

Abstract

The invention discloses an ethosome gel film-coating agent with multiple wound repair effects and a preparation method of the ethosome gel film-coating agent. The film-coating agent is prepared by taking tea polyphenol, asiaticoside, tea tree oil, amino acid, vitamin C, soybean phospholipid, cholesterol and medical absolute ethyl alcohol as active ingredients of lipidosome, packaging by carboxylation chitosan, and taking sodium carboxymethyl starch and sodium alginate as a gel substrate. The preparation method comprises preparing of ethosome liquor, packaging of ethosome and preparing of the gel film-coating agent. According to the invention, the carboxylation chitosan is firstly used to package the ethosome very well, and in the obtained film-coating agent, triple wound repair function is formed by virtue of a preparation way from inside to outside. The film-coating agent is used to provide a low-oxygen wet micro environment for a wound tissue, water-soluble medicines and fat-soluble medicines inside the ethosome and carboxylation chitosan packaged outside are released to the wound part for promoting healing and nutrition supplying of the wound tissue. The ethosome gel film-coating agent is suitable for wound clinical care and treatment.

Description

technical field [0001] The present invention relates to a medical preparation characterized by a special physical shape, in particular to a medical dressing, especially to an ethosome gel coating agent. technical background [0002] Trauma, including incision wounds, abrasions, burns, etc., is an accident that often occurs in daily life. After trauma, a series of treatments such as debridement, disinfection, and wound coverage are required to facilitate the repair of wounded tissues. In the process of wound repair, it usually needs to go through three processes, namely, the stage of local inflammatory response, the stage of cell proliferation and differentiation and granulation formation, and the stage of tissue reconstruction. Therefore, the treatment of wound tissue must focus on anti-inflammatory and antibacterial, nutritional supplementation, promotion of granulation growth, and inhibition of scar tissue formation. [0003] The gel coating agent is a new type of wound d...

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Problems solved by technology

[0005] In the Chinese patent literature database, although there are many patents and applications related to ethosomes, there are patents and applications related to the encapsulation of water-soluble drugs and fat-soluble drugs in the same ethosome preparation and preparation method No report

[0006] In the Chinese patent literature database, there are only 3 patents and applications related to ethosome gel preparations, which are respectively No. 201010179567.1 "Scutellarin etosome gel preparation and its preparation method" Chinese medicine ethosome gel patch for treating herpes zoster and its preparation method" and No. 200410015700.4 "finasteride ethosome gel preparation", although these 3 patent applications made etosome gel, But it neither has a membrane-forming type nor its liposomes are wrapped by macromolecular substances

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