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A kind of oil-resistant stomach-soluble film coating premixed auxiliary material and preparation method thereof

A technology of coating premixed excipients and stomach-soluble films, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, drug delivery, etc., to achieve the effects of improving compactness, reducing molecular gaps, and facilitating preparation

Active Publication Date: 2016-10-05
CHENGDU KETE COATING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to overcome the shortcoming of prior art, provide a kind of oil resistance gastro-soluble type film coating premixed auxiliary material, the coating premixed auxiliary material of the present invention fully utilizes the characteristics of HPMCE5, HPMCE15, HPMCE50, reasonable compatibility, the obtained package The coating plays a moisture-proof role for the extracts, successfully solves the problem that the traditional Chinese medicine extracts ooze out of the coating film under the influence of damp heat, avoids the medicines from being damp and hardened, prevents the loss of drug efficacy, and has oil resistance; Another object is to provide a method for preparing an oil-resistant gastric-soluble film-coated premixed auxiliary material, which has the advantages of simple operation, convenient preparation, high production efficiency, and low energy consumption, and is suitable for large-scale industrial production

Method used

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  • A kind of oil-resistant stomach-soluble film coating premixed auxiliary material and preparation method thereof
  • A kind of oil-resistant stomach-soluble film coating premixed auxiliary material and preparation method thereof
  • A kind of oil-resistant stomach-soluble film coating premixed auxiliary material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: a kind of oil-resistant stomach-dissolving type film coating premixed auxiliary material, it is made up of the raw material of following weight part:

[0026] HPMCE5: 9; HPMCE15: 14;

[0027] HPMCE50: 15; 3000 mesh talcum powder: 20;

[0028] Polyethylene glycol: 9; Titanium dioxide: 3.

[0029] The preparation method of the above-mentioned oil-resistant stomach-soluble film coating premixed auxiliary material comprises the following steps:

[0030] S1. Weighing: Accurately weigh each raw material according to the above ratio, and set aside;

[0031] S2. Premixing: Put the above-mentioned weighed raw materials into a ziplock bag and mix for 4 minutes;

[0032] S3. Pulverization: put the premixed raw materials into an ultrafine pulverizer and grind them for 100 minutes, and pass the ground raw materials through a 70-mesh sieve to obtain a coating powder;

[0033] S4. Preparation: dissolve the coating powder in purified water, and stir for 40 minutes to ...

Embodiment 2

[0035] Embodiment 2: a kind of oil-resistant stomach-soluble film coating premixed auxiliary material, it is made up of the raw material of following weight portion:

[0036]

[0037] The preparation method of the above-mentioned oil-resistant stomach-soluble film coating premixed auxiliary material comprises the following steps:

[0038] S1. Weighing: Accurately weigh each raw material according to the above ratio, and set aside;

[0039] S2. Premixing: Put the above-mentioned weighed raw materials into a ziplock bag and mix for 8 minutes;

[0040] S3. Pulverization: put the premixed raw materials into an ultrafine pulverizer and grind for 120 minutes, pass the ground raw materials through a 100-mesh sieve to obtain a coating powder;

[0041] S4. Preparation: dissolve the coating powder in purified water, stir for 50 minutes, and prepare a coating solution with a concentration of 20%;

[0042] S5. Spraying: Spray the coating liquid on the tablets with a sugar coating pan...

Embodiment 3

[0043] Embodiment 3: a kind of oil-resistant stomach-soluble type film coating premixed auxiliary material, it is made up of the raw material of following weight portion:

[0044]

[0045] The preparation method of the above-mentioned oil-resistant stomach-soluble film coating premixed auxiliary material comprises the following steps:

[0046] S1. Weighing: Accurately weigh each raw material according to the above ratio, and set aside;

[0047] S2. Premixing: Put the above-mentioned weighed raw materials into a ziplock bag and mix for 6 minutes;

[0048] S3. Pulverization: put the premixed raw materials into an ultrafine pulverizer and grind for 108 minutes, pass the ground raw materials through an 80-mesh sieve to obtain a coating powder;

[0049] S4. Preparation: dissolve the coating powder in purified water, stir for 44 minutes, and prepare a coating solution with a concentration of 15%;

[0050] S5. Spraying: Spray the coating solution on the tablets with a sugar coatin...

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Abstract

The invention discloses an oil-resistant gastric-soluble type film coating premix auxiliary material and a preparation method thereof. The oil-resistant gastric-soluble type film coating premix auxiliary material is prepared from the following raw materials in parts by weight: 9-10 parts of HPMCE (medicinal hydroxypropyl methyl cellulose) 5, 14-15 parts of HPMCE 15, 15-16 parts of HPMCE 50, 20-22 parts of talcum powder, 9-12 parts of polyethylene glycol and 3-5 parts of pigment. The preparation method for the oil-resistant gastric-soluble type film coating premix auxiliary material comprises weighing, pre-mixing, crushing, preparing and spraying. The oil-resistant gastric-soluble type film coating premix auxiliary material prepared by the preparation method disclosed by the invention plays a moistureproof role on medicines such as extracts, successfully solves the problem of the seepage of coating films of the traditional Chinese medicines such as extracts due to damp and hot influence, prevents the medicines from being affected with damp and hardened, prevents the loss of efficacy, and has oil resistance; the preparation method for the oil-resistant gastric-soluble type film coating premix auxiliary material has the advantages of being simple to operate, convenient to prepare, high in production efficiency and low in energy consumption, and is suitable for large-scale factorial production.

Description

technical field [0001] The invention relates to a film-coating premixed auxiliary material and a preparation method thereof, in particular to an oil-resistant stomach-soluble film-coated premixed auxiliary material and a preparation method thereof. Background technique [0002] Coating is one of the most important and cutting-edge processes in modern pharmaceuticals. It is to coat sugar or other film-forming materials on the outer surface of pharmaceutical solid preparations in specific equipment according to a specific process. After drying, it becomes one or several layers of multi-functional protective layers with different thicknesses and different elasticity that are precisely adhered to the surface. This multi-functional protective layer is called coating. [0003] Oral dosage forms of pharmaceutically active compounds, such as tablets, in order to be administered in tablet form, it is often necessary to mask the unpleasant taste of the pharmaceutically active compound...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K9/36
Inventor 晏新连
Owner CHENGDU KETE COATING TECH
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