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Polymers, their preparation and applications

A technology of polymers and groups, applied in the field of polymers and its preparation, can solve the problems of poor stability of polyethylene glycol, achieve excellent biological inertness, broaden the application range, and the effect of a wide application range

Active Publication Date: 2017-06-09
张昊 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a polymer to replace polyethylene glycol and solve the problem of poor stability of polyethylene glycol

Method used

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  • Polymers, their preparation and applications
  • Polymers, their preparation and applications
  • Polymers, their preparation and applications

Examples

Experimental program
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preparation example Construction

[0043] The embodiment of the present invention further provides the above polymer preparation method, comprising the following steps:

[0044] Step S01, preparing an intermediate product:

[0045] Add 2-methyl-2-oxazoline and an initiator into an organic solvent, and react at a temperature of 60-80°C for 6-48 hours;

[0046] Step S02, introducing end groups, purifying:

[0047] Adjust the temperature to room temperature, add a terminator, stir and react for 2-24 hours, remove the solvent in the solution after the reaction, add water and stir, and dialyze and dry to obtain a polymer. The initiator is selected from methyl trifluoromethanesulfonate, Iodomethane, ethyl iodide, 1-iodo-n-propane, 1-iodo-isopropane, 1-iodo-n-butane, 1-iodo-tert-isobutane, 1-iodo-tert-butane, etc., the terminator is selected from terminal bands Compounds with hydroxy, amino, mercapto, azido or trimethyl(ethyl)oxyalkyl;

[0048] or,

[0049] Adjust the temperature to room temperature, add a compoun...

Embodiment 1

[0070] The chemical structural formula of the embodiment polymer of the present invention is as follows:

[0071]

[0072] The polymer preparation method of the embodiment of the present invention comprises the following steps:

[0073] 2-Methyl-2-oxazoline (8.50mL, 100mmol) was dissolved in acetonitrile (30mL), and methyl trifluoromethanesulfonate (0.44mL, 4.0mmol) was added to the reaction system, after which the mixture was heated to 70°C, react for 8 hours;

[0074] Then stop heating, wait for the mixture to cool to room temperature, and remove part of the solvent by heating under negative pressure to obtain an oily viscous liquid. Adjust to neutrality, then transfer the polymer-containing solution to a dialysis bag, and dialyze in deionized water for 24 hours. Finally, the solution containing the polymer was freeze-dried or dried under reduced pressure to obtain a white solid of poly(2-methyl-2-oxazoline) with an average molecular weight of about 1.8K.

[0075] see ...

Embodiment 2

[0077] The chemical structural formula of the embodiment polymer of the present invention is as follows:

[0078]

[0079] The polymer preparation method of the embodiment of the present invention comprises the following steps:

[0080] 2-Methyl-2-oxazoline (8.50mL, 100mmol) was dissolved in acetonitrile (30mL), then methyl trifluoromethanesulfonate (0.22mL, 2.0mmol) was added to the reaction system, and the mixture was heated to 70°C, react for 16 hours;

[0081] Then the heating was stopped, and when the mixture was cooled to room temperature, ethyl 4-piperidinecarboxylate (2.448 mL, 16 mmol) was added and stirred for 12 hours;

[0082] Part of the solvent was removed by heating under negative pressure to obtain an oily viscous liquid. After adding deionized water to 50mL, it was hydrolyzed for 24 hours under the condition of pH=14, and the pH of the solution was adjusted to neutral. The solution was transferred to a dialysis bag and dialyzed against deionized water for...

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Abstract

The invention is applicable to the field of polymer materials, and provides a polymer, its preparation method and application. The polymer has the following structural formula. The polymer of the present invention comprises a polyoxazoline group and a hydroxyl group, a carboxyl group, an amino group, a mercapto group, an azido group or a trimethyl (ethyl) oxysilyl group, and through the polyoxazoline group, the polymer of the present invention has Very excellent biological inertness, stability and ease of synthesis, through the active functional groups such as hydroxyl, carboxyl, amino, mercapto, azido or trimethyl(ethyl)oxysilyl, the polymer can be formed with other functional groups The cross-linking reaction greatly broadens the scope of application of the polymer; the preparation method of the polymer of the present invention realizes that the polymer has excellent biological inertia, stability and ease of use by introducing polyoxazoline groups and other active functional groups. Synthetic and capable of cross-linking reactions with other functional groups, it has a wide range of applications.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a polymer, its preparation method and application. Background technique [0002] In recent decades, due to the rapid growth of demand for biomedical products such as artificial implants, drug delivery systems, imaging contrast agents and biochips, the application of antifouling (also known as bioinert) polymer materials in surface coatings has been rapid. develop. In addition, these materials also have great application prospects in the field of antimicrobial growth, such as antibacterial food packaging, antibacterial refrigerator linings, antibacterial fabrics, and anti-algae growth on ship surfaces. Generally speaking, these polymer materials have the characteristics of hydrophilicity, electrical neutrality, and hydrogen bond acceptors. When these materials are modified onto solid surfaces, they are highly hydrated in aqueous solutions. In the case of optimizing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/02
Inventor 陈寅碧达瑞·皮达哈提卡鲁伯特·康达迪马克斯·特科思特
Owner 张昊
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