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Reference compound used in the analysis of flupirtine maleate

A technology of flupirtine maleate and a compound is applied in the application field of flupirtine maleate drug analysis, which can solve the problems of affecting the accuracy of samples, easy discoloration, instability of flupirtine maleate, etc. High accuracy, good reproducibility, and the effect of improving purity and content

Active Publication Date: 2015-12-02
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] During the experiment, we found that flupirtine maleate is extremely unstable, and the sample is very easy to change color during the placement process, which will affect the accuracy of the sample measurement. Therefore, it needs to be operated under specific conditions, such as: avoiding light, mixing samples Store in a dark place at a lower temperature

Method used

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  • Reference compound used in the analysis of flupirtine maleate
  • Reference compound used in the analysis of flupirtine maleate
  • Reference compound used in the analysis of flupirtine maleate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Weigh 20.0 g of flupirtine maleate, add 200 mL of anhydrous methanol, heat to 80°C, stir to dissolve, and keep the temperature for 48 hours. Filtration, column chromatography, eluting with dichloromethane:methanol 100:1 respectively, to obtain impurity A and impurity B.

Embodiment 2

[0082] Dissolve 20g ANFP (2-amino-3-nitro-6-p-fluorobenzylaminopyridine) in anhydrous methanol, add 5% palladium carbon, complete the reaction under 20 kg pressure, spin dry, dissolve in dichloromethane 13 mL of triethylamine was added, methyl chloroformate was added at 0-25°C, and compound C was obtained by spin-drying.

Embodiment 3

[0084] Weigh 20.0 g of compound C, add 200 mL of dimethylformamide: water (20:1), heat to 110°C, stir to dissolve, and keep the temperature for 48 hours. Filtration, column chromatography, eluting with dichloromethane:methanol 100:1 respectively, to obtain impurity D and impurity E.

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Abstract

The invention belongs to the technical field of medicine and relates to impurity compounds A, B, C, D and E for flupirtine maleate analysis and a use of the impurity compounds in flupirtine maleate drug analysis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to impurity compounds A, B, C, D and E used in the analysis of flupirtine maleate and their application in the analysis of flupirtine maleate. Background technique [0002] Flupirtine maleate, chemical name 2-amino-3-acetylamino-6-(p-fluorophenylamino)-pyridine, ethyl-2-amino-6-[(p-fluorophenyl)amino]- 3-Pyridine-carbamate maleate: [0003] [0004] Molecular formula: C 15 h 17 FN 4 o 2 ·C 4 h 4 o 4 , molecular weight: 420.41 [0005] Flupirtine maleate is a selective neuronal potassium channel opener and a non-opioid analgesic that acts on the central nervous system without producing dependence and tolerance. Flupirtine maleate activates G protein-coupled K on nerve cell membrane + Channel.K + Efflux stabilizes the resting membrane potential. Cell membrane activity is reduced, thereby indirectly inhibiting the activation of NMDA receptors. Therapeutic c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/75G01N30/02
CPCC07D213/75G01N30/02G01N2030/027
Inventor 张存彦韩冬董凯孙长海姚小青
Owner TIANJIN CHASE SUN PHARM CO LTD
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