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Nanoparticle preparation method

A technology of nanoparticles and active substances, which is applied in the direction of nanostructure manufacturing, nanomedicine, nanotechnology, etc., can solve the problems of large particle size and difficulty in preparing particles, and achieve the effect of large particle size

Active Publication Date: 2016-10-19
BIO SYNECTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0016] The present invention is proposed in order to solve the above-mentioned problems in the prior art, especially to overcome the limitation that it is difficult to prepare particles with a size below the micron unit in the previous dry and wet pulverization, and solve the problem of using a large amount of water in the previous wet pulverization. In the dehydration process after the pulverization process, the particle size becomes larger due to the growth of particles, and it is possible to simply and efficiently prepare nanoparticles that are soluble in water to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-9

[0044] With respect to 1 part by weight of itraconazole (itraconazole) as a model drug, a nonionic PEG ester surfactant is added as an essential surfactant (Polyethylene glycol glycerol stearate, Stearoyl polyoxyl-32glycerides, melting point 50°C, HLB 13) 0.5 parts by weight, biocompatible high molecular polymer polyvinylpyrrolidone (PVP) k30 0.5 parts by weight and sugars 2 parts by weight of mannitol were uniformly mixed. In order to confirm the influence of the moisture content in the mixture on the particle size, deionized water corresponding to 1 or 5% by weight of the total weight of the mixture powder was added in some examples, and then uniformly mixed again. For the prepared mixture, according to different examples, using a roller press with a constant roller temperature of 20, 30, and 40° C., the pulverization process was continuously performed 30 times, thereby preparing a granular powder containing an active substance. The prepared particle powder was added to de...

Embodiment 10

[0049] Nanoparticles containing itraconazole were prepared by the same method as in Example 1 except that mannitol was not used, and the particle size was also measured by the same method as in Example 1. The average particle size was determined to be 0.434 μm and the median particle size was 0.379 μm.

Embodiment 11-14

[0051] 1 part by weight of itraconazole and necessary surfactant 1 part by weight is uniformly mixed. In some examples, 1 or 5% by weight of deionized water was added to the total weight of the mixture powder, and then uniformly mixed again. For the prepared mixture, the pulverization process was continuously performed 30 times using a roller press with a constant roller temperature of 20 or 40° C. according to different examples, thereby preparing a granular powder containing the active substance. The prepared particle powder was added to deionized water at a concentration of 1 mg / ml based on itraconazole, stirred for 25 minutes, followed by ultrasonic treatment for 1 minute to completely disperse, and then the particle size was measured using HORIBA-LA950. The roll temperature, moisture addition amount, and measured particle size (Mean Size: average particle size, Median Size: particle size of the median particle size (50%)) of each example are shown in Table 2 below.

[0...

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Abstract

The invention relates to a method for preparing active material particles at the nanometer level, specifically, uniformly mixing a surfactant with an HLB value of 8 or more and a melting point or a glass transition temperature below 80°C and an active material, and rolling the mixture Machine pulverization, so that the active substance is prepared into a method of nanoparticle powder.

Description

technical field [0001] The present invention relates to the preparation method of the active material particle of nanometer level, specifically, relate to HLB value more than 8, and melting point or glass transition temperature is below 80 ℃ Surfactant and active material are uniformly mixed, and utilize roller press ( Roller mill) pulverizes the mixture to prepare the active substance into a nanoparticle powder. Background technique [0002] Technologies capable of rapidly and efficiently producing particles of very small size and maintaining a certain size are required in various industrial fields. Small particles that maintain a certain size have many advantages, and among them, especially good fluidity and almost no deviation in the interaction between particles are considered to be very useful advantages in industry. For example, in the pharmaceutical industry, the size of therapeutic agent particles becomes a very important factor in terms of decomposition speed, biol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B82B3/00B82B1/00A61K9/16
CPCA61K9/145A61K9/146A61K9/5123A61K9/5138A61K31/122A61K31/443A61K31/496A61K9/5146A61K9/5192B82B3/0095B82Y5/00
Inventor 金甲植朴珠媛
Owner BIO SYNECTICS