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A kind of preparation method and application of Biyuan soft capsule

A soft capsule and biyuan technology, applied in the field of preparation of Biyuan soft capsules, can solve the problems of large dosage of patients, many impurities, affecting clinical application, etc., and achieve the effect of reducing dosage and dosage.

Active Publication Date: 2015-09-30
云南云龙制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Biyuan Soft Capsules, but the methods of steam distillation and water decoction are rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient Taking it seriously affects the clinical application of this product

Method used

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  • A kind of preparation method and application of Biyuan soft capsule
  • A kind of preparation method and application of Biyuan soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Get Fructus Xanthii 1344g, Magnolia Magnoliae 252g, Honeysuckle 84g, Rubia 84g, and Wild Chrysanthemum 84g and join in CO2 supercritical extractor, ethanol is used as entrainer, and entrainer accounts for 4% by volume of total extraction solvent, extraction pressure 15MPa, temperature 30°C, CO 2 Flow rate 1m1 / g crude drug·min, extraction time 150min, to obtain supercritical extract, add appropriate amount of soybean oil, mix, grind with colloid mill, cool to room temperature, press into 1000 soft capsules, dry, remove oil, dry in the air, that is have to.

Embodiment 2

[0031] Take 1344g cocklebur, 252g magnolia, 84g honeysuckle, 84g madder, and 84g wild chrysanthemum and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, and an appropriate amount of soybean oil is added, mixed, ground with a colloid mill, cooled to room temperature, compressed into 1000 soft capsules, dried, degreased, and dried in the air. have to.

Embodiment 3

[0033] Take 1344g cocklebur, 252g magnolia, 84g honeysuckle, 84g madder, and 84g wild chrysanthemum and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 20MPa, the temperature is 40°C, and CO 2Flow rate 2m1 / g crude drug·min, extraction time 160min, to obtain supercritical extract, add appropriate amount of soybean oil, mix, grind with colloid mill, cool to room temperature, press into 1000 soft capsules, dry, remove oil, dry in the air, that is have to.

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Abstract

The invention provides a preparation method of a nasosinusitis soft capsule. The nasosinusitis soft capsule is prepared by taking 1344g of fructus xanthii, 252g of flos magnolia, 84g of honeysuckle, 84g of madder, 84g of chrysanthemum indicum and proper amount of soybean oil as raw material medicines through supercritical extraction, so that content is greatly improved and dose is reduced. The invention further provides application of the nasosinusitis soft capsule in preparing drugs for inhibiting cell proliferation of human glioma cells SF295 and drugs for inhibiting constipation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Biyuan soft capsules. Background technique [0002] Biyuan Soft Capsules are recorded in the ministerial standards. The prescription is 1344g cocklebur, 252g magnolia, 84g honeysuckle, 84g madder, 84g wild chrysanthemum, appropriate amount of soybean oil. The aqueous solution was collected in another device, and the dregs and cocklebur seeds were decocted twice with 8 times the amount of water, each time for 3 hours, the decoction was combined, filtered, the filtrate was combined with the above aqueous solution, and concentrated to a relative density of 1.10-1.20 (80 ℃), add ethanol so that the alcohol content is 60%, stir, stand still, and filter; the precipitate is washed with 60% ethanol, and the washing liquid is incorporated into the filtrate. The percolation method (an appendix 10 of the Chinese Phar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K9/48A61P35/00A61P1/10
Inventor 杨建云
Owner 云南云龙制药股份有限公司