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Device and method for simulating human digestive and fermentation system

A fermentation and digestion room technology, which is applied to measurement devices, teaching models, educational appliances, etc., can solve the problems of little correlation, no detailed description of the specific digestion of the simulated oral cavity, and insufficient description of parameters.

Active Publication Date: 2016-04-20
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patent reports have greatly enriched the devices and methods of use suitable for digestive fermentation, but so far, these patents have not detailed the simulation of oral cavity specific digestion
Secondly, these patents have no detailed simulation and description of the gastric emptying process in the simulation of the stomach
At the same time, these patents are not detailed enough to control the parameters in the small intestine simulation system and the large intestine fermentation system
Some of these patents are based only on animal-related parameters and have little relevance to humans

Method used

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  • Device and method for simulating human digestive and fermentation system
  • Device and method for simulating human digestive and fermentation system
  • Device and method for simulating human digestive and fermentation system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Human digestive glycolysis simulation of plant polysaccharides.

[0022] 1. Raw material preparation.

[0023] (1) Saliva.

[0024] Fresh clarified saliva samples were collected from a healthy volunteer. The volunteer had no chronic diseases and had not used antibiotics for at least 3 months. Before saliva collection, the volunteer was restricted from eating and drinking. Collection is by direct spitting. The collected saliva was centrifuged at 1500×g for 10 minutes to remove cells, and the supernatant was stored at -20°C until use.

[0025] (2) Gastric juice.

[0026] Gastric juice is obtained by weighing 30mg of gastric lipase and 30mg of pepsin into 150g of gastric electrolyte (preparation of gastric electrolyte solution: weigh 3gNaCl, 0.5gKCl, 0.1gCaCl 2 , 0.5g NaHCO 3 , use deionized water to make up the volume in a 1L volumetric flask, use 0.1M HCl to adjust the pH of the electrolyte solution to 3), then add 1mL CH 3 COONa (1M, pH 5). Stir magnetically at...

Embodiment 2

[0045] Human digestive glycolysis simulation of cornstarch.

[0046] 1. Raw material preparation.

[0047] (1) Saliva.

[0048] Fresh clarified saliva samples were collected from a healthy volunteer. The volunteer had no chronic diseases and had not used antibiotics for at least 3 months. Before saliva collection, the volunteer was restricted from eating and drinking. Collection is by direct spitting. The collected saliva was centrifuged at 1500×g for 10 minutes to remove cells, and the supernatant was stored at -20°C until use.

[0049] (2) Gastric juice.

[0050] Gastric juice is obtained by weighing 30mg of gastric lipase and 30mg of pepsin into 150g of gastric electrolyte (preparation of gastric electrolyte solution: weigh 3gNaCl, 0.5gKCl, 0.1gCaCl 2 , 0.5g NaHCO 3 , use deionized water to make up the volume in a 1L volumetric flask, use 0.1M HCl to adjust the pH of the electrolyte solution to 3), then add 1mL CH 3 COONa (1M, pH 5). Stir magnetically at room tempe...

Embodiment 3

[0069] Human digestive glycolysis simulation of soybean protein.

[0070] 1. Raw material preparation.

[0071] (1) Saliva.

[0072] Fresh clarified saliva samples were collected from a healthy volunteer. The volunteer had no chronic diseases and had not used antibiotics for at least 3 months. Before saliva collection, the volunteer was restricted from eating and drinking. Collection is by direct spitting. The collected saliva was centrifuged at 1500×g for 10 minutes to remove cells, and the supernatant was stored at -20°C until use.

[0073] (2) Gastric juice.

[0074] Gastric juice is obtained by weighing 30mg of gastric lipase and 30mg of pepsin into 150g of gastric electrolyte (preparation of gastric electrolyte solution: weigh 3gNaCl, 0.5gKCl, 0.1gCaCl 2 , 0.5g NaHCO 3 , use deionized water to make up the volume in a 1L volumetric flask, use 0.1M HCl to adjust the pH of the electrolyte solution to 3), then add 1mL CH 3 COONa (1M, pH 5). Stir magnetically at room ...

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Abstract

The invention discloses a device for simulating a human digestive and glycolytic system and an application method thereof. The device comprises an oral digestion area, a gastric digestion area, a small intestine digestion area, a large intestine anterior-segment glycolysis area and a large intestine posterior-segment glycolysis area. An object to be measured is added into an inlet at the top of the device; all thermostatic waterbath system is turned on and the temperature remains constant at 37 DEG C; and all constant flow pumps and flow dividers are opened. Full dynamic flow of the object to be measured in the digestive system is realized, and the object to be measured successively undergoes oral digestion, gastric digestion, small intestine digestion, large intestine anterior-segment glycolysis and large intestine posterior-segment glycolysis. Digestion and glycolysis processes are simulated repeatedly for three times; digestion and glycolysis products at each part are collected; and digestion and glycolysis conditions of the object to be measured are detected. Simulation of digestion and glycolysis at each part is carried out completely according to the human digestive and glycolytic processes and physiological environment. Full dynamic simulation of digestive and glycolytic processes at each part is realized. Digestive and glycolytic conditions of various active or nutrient substances which enter human body can be observed. The device provided by the invention fits real human physiological environment.

Description

technical field [0001] The invention relates to a device for simulating a human body's digestion and fermentation system and a method for using it. Background technique [0002] The world's authoritative journals stated that it is very important to study the effects of food or active substances in the human body and their mechanisms of action, because the elucidation of the mechanism of action in vivo can provide a research basis for maximizing the use of food or active substances in the human body. It can exert its physiological efficacy more effectively, and at the same time, it has guiding significance for avoiding its possible adverse side effects. The actual physiological effects of a food or active substance largely depend on what is the product of its digestion and fermentation by the human body. For the consideration of ethics in human body research, the in vitro simulation of human digestion and fermentation has become the technical key to the research on the mecha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/00G09B23/28
Inventor 聂少平胡婕伦谢明勇
Owner NANCHANG UNIV