Microemulsion nano-delivery system of traditional Chinese medicine components and its preparation method and application in the preparation of pharmaceutical preparations
A technology of traditional Chinese medicine components and delivery systems, applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., can solve the problem of low oral bioavailability of insoluble Chinese medicine components, excessive use of conventional microemulsion excipients, low drug loading, etc. Problems, to achieve the effect of enhancing oral absorption and utilization, increasing drug loading, and high drug loading
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0052] Example 1, the preparation scheme of coix seed oil-ginsenoside microemulsion (CG-ME):
[0053] Take 1.0g coix seed oil and 1.0g ginsenosides, stir at room temperature for 4-6h, mix thoroughly, add 0.5g co-emulsifier PEG-400 to the above mixing system, continue stirring at room temperature for 3-6h, set aside. 3–6mL of deionized water was slowly dropped into the above-prepared mixing system at a constant speed, and the system was continuously stirred at a constant speed until a transparent and clear system appeared.
Embodiment 2
[0054] Embodiment 2, the preparation scheme of Chinese medicine oils-ginsenoside microemulsion (OG-ME):
[0055] Taking Brucea javanica oil as an example, take 0.8g Brucea javanica oil and 0.75g ginsenosides, stir at room temperature for 2 hours, mix thoroughly, add 0.4g co-emulsifier PEG-400 to the above mixing system, and continue stirring at room temperature for 4-6 hours ,spare. 3–6mL of deionized water was slowly dropped into the above-prepared mixing system at a constant speed, and the system was continuously stirred at a constant speed until a transparent and clear system appeared.
[0056] Similarly, the corresponding microemulsions of zedoary oil, linseed oil, catmint oil, Atractylodes macrocephala oil, and clove oil can all be prepared by the same method as above.
Embodiment 3
[0057] Example 3, the preparation scheme of coix seed oil-noginsenoside microemulsion (CN-ME):
[0058] Take 1.1g coix seed oil and 0.8g notoginseng saponins, stir at room temperature for 4-6h, mix thoroughly, add 0.4g co-emulsifier PEG-400 to the above mixing system, continue stirring at room temperature for 3-6h, set aside. 3–6mL of deionized water was slowly dropped into the above-prepared mixing system at a constant speed, and the system was continuously stirred at a constant speed until a transparent and clear system appeared.
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More