Plant mass cement for preparing hollow capsule, as well as hollow capsule of plant mass cement
A technology of hollow capsules and plant matter, which is applied in the direction of capsule delivery, medical preparations of non-active ingredients, and applications. It can solve the problems of long capsule disintegration time, low market share, and difficult molding, and achieve paste silk Shorter, lower viscosity, easier to process and shape
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Embodiment 1
[0017] 12wt% of hydroxypropyl methylcellulose (at 20°C, a concentration of 2wt% hydroxypropylmethylcellulose in aqueous solution has a viscosity of 7.0mpa s), 7wt% of acid-treated hydroxypropyl cassava Starch (degree of substitution DS=0.55, acid-treated hydroxypropyl tapioca starch is obtained by hydrochloric acid degradation and viscosity-reducing treatment of cassava starch, and then prepared with propylene oxide through a conventional reaction method in the starch industry), 0.4wt% konjac gum and The rest of the water is mixed to obtain the plant gum for preparing the hollow capsule.
[0018] The hydroxypropyl methylcellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared hydroxypropyl methylcellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and...
Embodiment 2
[0020] 22wt% of hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa·s), 3wt% of hydroxypropyl wheat starch (substituted Degree DS=0.08, hydroxypropyl wheat starch is prepared by wheat starch and propylene oxide through the conventional reaction mode of starch industry), 2wt% carrageenan and the rest of the water are mixed to obtain the vegetable gum for preparing hollow capsules .
[0021] The hydroxypropyl methylcellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared hydroxypropyl methylcellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the disintegration experiment was carried out with Tianda Tianfa ZB-1E intelligent disintegration instrument, and all 50 samples were test...
Embodiment 3
[0023] With 25wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa s), 0.1wt% hydroxypropyl cornstarch ( The degree of substitution DS=0.004, hydroxypropyl cornstarch is prepared by cornstarch and propylene oxide through the conventional reaction mode of starch industry), 1wt% locust bean gum and the rest of the water are mixed to obtain the plant for preparing hollow capsules Glue.
[0024] The hydroxypropyl methylcellulose hollow capsules are prepared by using the conventional capsule preparation process and using the vegetable gum obtained above for the preparation of the hollow capsules. The prepared hydroxypropyl methylcellulose hollow capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the disintegration experiment was carried out by using Tianda Tianfa ZB-1E intelligent disintegration instrument, and all 50 samples ...
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