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An absorbable skin suture staple and its preparation method

A technology for suturing nails and skin, applied in the field of medical equipment, can solve problems such as low tissue healing quality, poor dimensional stability under force, and material disintegration, and achieve good melt rheological properties, good dimensional stability, and good processing performance Effect

Active Publication Date: 2015-09-16
BEIJING EHANRI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem mainly solved by the present invention is to provide an absorbable skin suture staple and its preparation method, which can solve the problem that the material of the absorbable skin suture staple in the prior art disintegrates within three weeks, which does not conform to the healing law of the human body, mechanical The strength is very low, the dimensional stability under force is also poor, the quality of tissue healing is low, and the technical problems of processing and sterilization are difficult

Method used

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  • An absorbable skin suture staple and its preparation method
  • An absorbable skin suture staple and its preparation method
  • An absorbable skin suture staple and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0023] In the first embodiment of the absorbable skin staples of the present invention, the material of the absorbable skin staples is a random copolymer of L-lactide (left-handed lactide) and glycolide, in the random copolymer The molar content of L-lactide is 50%-70%, and the molar content of glycolide is 30%-50%.

[0024] The intrinsic viscosity of the random copolymer (measured at 30°C with 0.1% hexafluoroisopropanol as a solvent, the same below) is 1.2-2.0dl / g, and the residual monomer content is not more than 1% , the moisture content is less than 500ppm (parts permillion, a part per million, 500ppm is five hundred millionths). The random copolymer has good melt rheological properties and is easy to process.

[0025] Regarding the intrinsic viscosity of the random copolymer, when the intrinsic viscosity of this type of random copolymer material is lower than 1.0dl / g, the processability is poor, and the mechanical strength of the absorbable skin staple product obtained b...

no. 2 example

[0030] In the second embodiment of the absorbable skin staples of the present invention, the material of the absorbable skin staples is a random copolymer of L-lactide and glycolide, and the L-lactide in the random copolymer The molar content is preferably 51%, and the molar content of glycolide is preferably 49%. The intrinsic viscosity of the random copolymer (intrinsic viscosity is measured at 30°C with 0.1% hexafluoroisopropanol as a solvent, the same below) is preferably 1.25dl / g, and the residual monomer content is preferably 0.65%, The moisture content is preferably 255 ppm.

[0031] The random copolymer of L-lactide and glycolide is used as raw material to produce absorbable skin suture staples through injection molding process. The specific parameters of injection molding process are: feed section temperature 155°C, melting section temperature 170°C, The temperature is 160°C and the injection pressure is 45bar.

[0032]The absorbable skin staples after the injection...

no. 3 example

[0034] In the third embodiment of the absorbable skin staple of the present invention, the material of the absorbable skin staple is a random copolymer of L-lactide and glycolide, and the L-lactide in the random copolymer The molar content is preferably 60%, and the molar content of glycolide is preferably 40%. The intrinsic viscosity of the random copolymer (intrinsic viscosity is measured at 30°C with 0.1% hexafluoroisopropanol as a solvent, the same below) is preferably 1.40dl / g, and the residual monomer content is preferably 0.50%, The moisture content is preferably 350 ppm.

[0035] The random copolymer of L-lactide and glycolide is used as raw material to produce absorbable skin suture staples through injection molding process. The specific parameters of injection molding process are: feed section temperature 160°C, melting section temperature 175°C, The temperature is 165°C and the injection pressure is 55bar.

[0036] After the injection molding process, the absorbab...

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Abstract

The invention discloses an absorbable skin suturing nail. The material of the absorbable skin suturing nail is a random copolymer of L-lactide and glycolide, wherein the molar ratio of L-lactide in the random copolymer is 50-70%, and the molar content of glycolide is 30-50%. In the manner, the absorbable skin suturing nail disclosed by the invention is high in mechanical strength, has certain mechanical strength retention within three weeks, is disintegrated after four weeks, and does not affect tissue healing. The absorbable skin suturing nail has good size stability during in-vivo mechanical strength retention. The random copolymer has good melt rheological properties, has excellent processing performance, and is convenient to be processed into the absorbable skin suturing nail.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to an absorbable skin staple and a preparation method. Background technique [0002] Skin suturing is the most basic type of surgery. The skin stapler is an indispensable medical device in surgery. Its working principle is basically the same as that of the stapler. The staples are fired, and the staples pierce the epidermis on both sides of the skin incision, and the metal nails deform and fix the epidermal tissue on both sides of the incision to achieve skin suture. The birth of the skin stapler has greatly reduced the operation time of the operation, improved the efficiency of the operation, reduced the work intensity of the doctor, and reduced the pain of the patient. There are two types of skin sutures, superficial sutures and subcutaneous sutures. There are also two types of skin staples, non-absorbable skin staples and absorbable skin staples. Non-absorbable skin staples are...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B17/03A61L31/06A61L31/14
Inventor 缪忠尉唐郁
Owner BEIJING EHANRI MEDICAL TECH CO LTD
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